Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Ryan, M. Dominic"'
Autor:
Denes Haase, John W. Cuozzo, John Barker, Pia Thommes, Michael Zahn, Avery Hunt, Vasileios Roumpelakis, Ying Zhang, Emily Trimby, Elise Gadouleau, Alain Dorali, Kostas Papadopoulos, Ole A. Andersen, Christoph E. Dumelin, Christel Compper, Michelle Southey, Christopher Lumley, Eric A. Sigel, Paolo A. Centrella, Barbara Mertins, Maisie Holbrow-Wilshaw, Spencer Napier, Adele Faulkner, Magali Dejob, Timothy Gorman, Alastair L Parkes, Boudewijn Dejonge, Thomas Krulle, Ricky Cain, Jennifer Williams, Boer Deng, Olivier Barbeau, Anthony D. Keefe, Sian Evans, David F. Corbett, Donnya Etheridge, Daniel B. Stein, Ryan M Dominic, Dawn M. Troast, Xianfu Li, Rajesh Odedra, Matthew A. Clark, Anthony P Dickie, Holly T Soutter, Kate Spear, Angelo Sanzone
Publikováno v:
Journal of Medicinal Chemistry. 64:14377-14425
This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of Pseudomonas ae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::561a3ec469b1a8704e6a0431f9d286c1
https://doi.org/10.1021/acs.jmedchem.1c00888
https://doi.org/10.1021/acs.jmedchem.1c00888
Akademický článek
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Autor:
Zhang, Jing, Chan, Audrey, Lippa, Blaise, Cross, Jason B., Liu, Christopher, Yin, Ning, Romero, Jan Antoinette C., Lawrence, Jonathan, Heney, Ryan, Herradura, Prudencio, Goss, Jennifer, Clark, Cynthia, Abel, Cassandra, Zhang, Yanzhi, Poutsiaka, Katherine M., Epie, Felix, Conrad, Mary, Mahamoon, Azard, Nguyen, Kien, Chavan, Ajit, Clark, Edward, Li, Tong-chuan, Cheng, Robert K., Wood, Michael, Andersen, Ole A., Brooks, Mark, Kwong, Jason, Barker, John, Parr, Ian Barrie, Gu, Yugui, Ryan, M. Dominic, Coleman, Scott, Metcalf, Chester A., III
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 April 2017 27(8):1670-1680
Autor:
Mesleh, Michael F., Cross, Jason B., Zhang, Jing, Kahmann, Jan, Andersen, Ole A., Barker, John, Cheng, Robert K., Felicetti, Brunella, Wood, Michael, Hadfield, Andrea T., Scheich, Christoph, Moy, Terence I., Yang, Qingyi, Shotwell, Joseph, Nguyen, Kien, Lippa, Blaise, Dolle, Roland, Ryan, M. Dominic
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 February 2016 26(4):1314-1318
Autor:
Ryan, M. Dominic1, Abu-Yousef, Imad A.2, Rys, Andrzej Z.3, Cheer, Clair J.4, Harpp, David N.3
Publikováno v:
Sulfur Letters. Feb2003, Vol. 26 Issue 1, p29. 5p.
Akademický článek
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Publikováno v:
International Journal of Quantum Chemistry. 107:1415-1429
Octahedral, six-coordinate Co2+ can exist in two spin states: S = 3/2 and S = 1/2. The difference in energy between high spin (S = 3/2) and low spin (S = 1/2) is dependent on both the ligand mix and coordination stereochemistry. B3LYP calculations on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84697168826283adf0d0ef9f73a59b9a
https://doi.org/10.1002/qua.21282
https://doi.org/10.1002/qua.21282
Autor:
Walter E. DeWolf, Dennis Lee, Ryan M Dominic, Cheryl A. Janson, Martha S. Head, Yanhong Feng, Nestor O. Concha, Paul M. Keller
Publikováno v:
Journal of Computer-Aided Molecular Design. 15:1105-1117
Structure-based design of a combinatorial array was carried out in order to identify non-peptidic thiomethylketone inhibitors of caspases 3 and 8. Five compounds from the designed array were active against caspase 3, and two were active against caspa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc6b9250e7363ec1e4dbc0bd6a9334e1
https://doi.org/10.1023/a:1015976725743
https://doi.org/10.1023/a:1015976725743
Autor:
Michael W. Lark, Christine Debouck, Kalindi Vaidya, Mark E. Nuttall, Kyung O. Johanson, James D. Winkler, Alison M. Badger, Martha S. Head, Paul M. Keller, Mark Alan Levy, R. Curtis Haltiwanger, Larry J. Suva, Cheryl A. Janson, Sherin S. Abdel-Meguid, Po-Huang Liang, Patrick McDevitt, George K. Chan, Nestor O. Concha, Daniel P. Nadeau, Kristine Kikly, Dennis Lee, Scott A. Long, Winnie Chan, Walter E. DeWolf, Ryan M Dominic, Susan B. Richardson, Maxine Gowen, Thaddeus A. Tomaszek, Terry A. Francis, Chiu-Mei Sung, Jerry L. Adams
Publikováno v:
Journal of Biological Chemistry. 275:16007-16014
Caspases have been strongly implicated to play an essential role in apoptosis. A critical question regarding the role(s) of these proteases is whether selective inhibition of an effector caspase(s) will prevent cell death. We have identified potent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ab9cad81cf835eb754a9108b2beebb
https://doi.org/10.1074/jbc.275.21.16007
https://doi.org/10.1074/jbc.275.21.16007