Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Ryan, Hutchinson"'
Autor:
Angelyn Anton, Ryan Hutchinson, Christopher M Hovens, Michael Christie, Andrew Ryan, Peter Gibbs, Anthony Costello, Justin Peters, Paul J Neeson, Niall M Corcoran, Ben Tran
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0301943 (2024)
BackgroundImmunotherapy has demonstrated limited activity in prostate cancer to date. This likely reflects an immune suppressive tumor microenvironment (TME), with previous studies suggesting low PD-L1 expression and a sparse immune cell infiltrate.
Externí odkaz:
https://doaj.org/article/772272e29c234320966f6e3aee2d4be1
Autor:
Ganesh V. Raj, Benjamin P.C. Chen, Ram S. Mani, Scott M. Dehm, Johann S. de Bono, Sandeep Burma, Felix Y. Feng, Neil B. Desai, Chao Xing, Solomon L. Woldu, Xihui Liu, Ryan Hutchinson, Xiangyi Li, Mohammed S. Kanchwala, Yunpeng Gao, Zhao Liu, Sam Ding, Susmita G. Ramanand, GuemHee Baek, Jeffrey Li, Sentai Ding, Kangling Xu, Rui Li, Yi Yin
ARV mediates DDR and clonogenic survival.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab34a344390b5ee39c68d750fa7a888c
https://doi.org/10.1158/0008-5472.22414325.v1
https://doi.org/10.1158/0008-5472.22414325.v1
Autor:
Ganesh V. Raj, Benjamin P.C. Chen, Ram S. Mani, Scott M. Dehm, Johann S. de Bono, Sandeep Burma, Felix Y. Feng, Neil B. Desai, Chao Xing, Solomon L. Woldu, Xihui Liu, Ryan Hutchinson, Xiangyi Li, Mohammed S. Kanchwala, Yunpeng Gao, Zhao Liu, Sam Ding, Susmita G. Ramanand, GuemHee Baek, Jeffrey Li, Sentai Ding, Kangling Xu, Rui Li, Yi Yin
In prostate cancer, androgen deprivation therapy (ADT) enhances the cytotoxic effects of radiotherapy. This effect is associated with weakening of the DNA damage response (DDR) normally supported by the androgen receptor. As a significant number of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e8f14bd1858f8a19b54cb8d7eec7525
https://doi.org/10.1158/0008-5472.c.6508943.v1
https://doi.org/10.1158/0008-5472.c.6508943.v1
Autor:
Rebecca Purvis, Daniel D. Buchanan, James M Chan, Ryan Hutchinson, Andrew J. Metz, Jihoon E. Joo, Romy Walker, Nathan Atkinson, Sharelle Joseland, Julia Como, Ingrid Winship, Galina Konycheva, Mark Clendenning, Mark A. Jenkins, Christophe Rosty, Varnika Vijay, Bernard J. Pope, Peter Georgeson, Catherine Beard, Finlay A. Macrae, Susan Parry, Julie Arnold, Susan Preston, Khalid Mahmood
Publikováno v:
Familial Cancer. 21:399-413
Germline loss-of-function variants in AXIN2 are associated with oligodontia and ectodermal dysplasia. The association between colorectal cancer (CRC) and colonic polyposis is less clear despite this gene now being included in multi-gene panels for CR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3334066ac8648e3c58fad331002543ce
https://doi.org/10.1007/s10689-021-00283-9
https://doi.org/10.1007/s10689-021-00283-9
Autor:
Marija Dinevska, Samuel S. Widodo, Liam Furst, Lucero Cuzcano, Yitong Fang, Stefano Mangiola, Paul J. Neeson, Phillip K. Darcy, Robert G. Ramsay, Ryan Hutchinson, Fabienne MacKay, Michael Christie, Stanley S. Stylli, Theo Mantamadiotis
Publikováno v:
Cellular oncology (Dordrecht).
Tumor cells thrive by adapting to the signals in their microenvironment. To adapt, cancer cells activate signaling and transcriptional programs and migrate to establish micro-niches, in response to signals from neighboring cells and non-cellular stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca6c5fa6d092d151bf1ea2206e5fe9f
https://pubmed.ncbi.nlm.nih.gov/36567397
https://pubmed.ncbi.nlm.nih.gov/36567397
Autor:
Finlay A. Macrae, Amanda B. Spurdle, Romy Walker, Christophe Rosty, Bernard J. Pope, Ryan Hutchinson, Jihoon E. Joo, Susan Preston, Ingrid Winship, Peter Georgeson, John L. Hopper, Mark Clendenning, Daniel D. Buchanan, Mark A. Jenkins, Julia Como, Aung Ko Win, Harindra Jayasekara, Khalid Mahmood, Sharelle Joseland
Publikováno v:
J Mol Diagn
Patients in whom mismatch repair (MMR)-deficient cancer develops in the absence of pathogenic variants of germline MMR genes or somatic hypermethylation of the MLH1 gene promoter are classified as having suspected Lynch syndrome (SLS). Germline whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3ad20cc6302d896568289c534b6907
https://doi.org/10.1016/j.jmoldx.2020.12.003
https://doi.org/10.1016/j.jmoldx.2020.12.003
Autor:
Romy Walker, Peter Georgeson, Khalid Mahmood, Jihoon E. Joo, Enes Makalic, Mark Clendenning, Julia Como, Susan Preston, Sharelle Joseland, Bernard J. Pope, Ryan Hutchinson, Kais Kasem, Michael D. Walsh, Finlay A. Macrae, Aung K. Win, John L. Hopper, Dmitri Mouradov, Peter Gibbs, Oliver M. Sieber, Dylan E. O’Sullivan, Darren R. Brenner, Steven Gallinger, Mark A. Jenkins, Christophe Rosty, Ingrid M. Winship, Daniel D. Buchanan
Identifying tumor DNA mismatch repair deficiency (dMMR) is important for precision medicine. We assessed tumor features, individually and in combination, in whole-exome sequenced (WES) colorectal cancers (CRCs) and in panel sequenced CRCs, endometria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::401a06189ff6ef2e3e997697db4edbeb
https://doi.org/10.1101/2022.06.20.22276419
https://doi.org/10.1101/2022.06.20.22276419
Autor:
Ryan Hutchinson, Alexander D. Barrow, Yitong Fang, Samuel S Widodo, Stefano Mangiola, Christopher M. Hovens, Stanley S. Stylli, Theo Mantamadiotis, Marija Dinevska, Phillip K. Darcy, Paul J Neeson
Publikováno v:
Cancer Immunology, Immunotherapy. 70:1811-1820
Recent developments in cancer immunotherapy promise better outcomes for cancer patients, although clinical trials for difficult to treat cancers such as malignant brain cancer present special challenges, showing little response to first generation im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aac30ab4147739d83deab1db1de018d2
https://doi.org/10.1007/s00262-020-02801-7
https://doi.org/10.1007/s00262-020-02801-7
Autor:
Arthur I. Sagalowsky, Vitaly Margulis, Yair Lotan, Syed M. Jafri, Gengyan Xiong, Jay D. Raman, Liqun Zhou, Zhenpeng Cao, Ryan Hutchinson, Dong Fang, Solomon L. Woldu, Xiaohong Su, Xuesong Li, Zhengqing Bao, Lei Zhang, Nirmish Singla
Publikováno v:
Cancer Management and Research
Dong Fang,1,* Nirmish Singla,2,* Zhengqing Bao,1,3,* Syed M Jafri,4 Xiaohong Su,1 Zhenpeng Cao,1 Gengyan Xiong,1 Lei Zhang,1 Solomon Woldu,2 Ryan Hutchinson,2 Arthur Sagalowsky,2 Yair Lotan,2 Xuesong Li,1 Jay D Raman,4 Vitaly Margulis,2 Liqun Zhou1 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aceca30b3f4af31c63f491ecf84b440
https://doi.org/10.2147/cmar.s267969
https://doi.org/10.2147/cmar.s267969
Autor:
Yair Lotan, Aditya Bagrodia, Xiaosong Meng, Nirmish Singla, Arthur I. Sagalowsky, Rashed Ghandour, I. Alex Bowman, Kevin D. Courtney, Ahmet M. Aydin, Nathan Chertack, Joseph A. Moore, Vitaly Margulis, Ryan Hutchinson, Yuval Freifeld, Solomon L. Woldu, Waddah Arafat
Publikováno v:
Cancer. 126:4362-4370
BACKGROUND The objective of this study was to determine whether standardized treatment of germ cell tumors (GCTs) could overcome sociodemographic factors limiting patient care. METHODS The records of all patients undergoing primary treatment for GCTs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91e2c240abba5001b5d0053e29dbbe07
https://doi.org/10.1002/cncr.33076
https://doi.org/10.1002/cncr.33076