Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ry R. Forseth"'
Autor:
Simone Bonazzi, Eva d’Hennezel, Rohan E.J. Beckwith, Lei Xu, Aleem Fazal, Anna Magracheva, Radha Ramesh, Artiom Cernijenko, Brandon Antonakos, Hyo-eun C. Bhang, Roxana García Caro, Jennifer S. Cobb, Elizabeth Ornelas, Xiaolei Ma, Charles A. Wartchow, Matthew C. Clifton, Ry R. Forseth, Bethany Hughes Fortnam, Hongbo Lu, Alfredo Csibi, Jennifer Tullai, Seth Carbonneau, Noel M. Thomsen, Jay Larrow, Barbara Chie-Leon, Dominik Hainzl, Yi Gu, Darlene Lu, Matthew J. Meyer, Dylan Alexander, Jacqueline Kinyamu-Akunda, Catherine A. Sabatos-Peyton, Natalie A. Dales, Frédéric J. Zécri, Rishi K. Jain, Janine Shulok, Y. Karen Wang, Karin Briner, Jeffery A. Porter, John A. Tallarico, Jeffrey A. Engelman, Glenn Dranoff, James E. Bradner, Michael Visser, Jonathan M. Solomon
Publikováno v:
Cell Chemical Biology. 30:235-247.e12
Autor:
Alexandra Vargas, Oliver Simon, Matthias Kittelmann, Melissa M. Lin, Chun-qi Zhu, Hongmei Li, Su-Er W. Huskey, Helen Gu, Sarah Favara, Handan He, Jin Zhang, Ry R. Forseth, Lai Wang, Alexandre Luneau, Heidi J. Einolf, Fabian K. Eggimann, James B. Mangold
Publikováno v:
Drug Metabolism and Disposition. 44:653-664
KAE609 [(1'R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyridol[3,4-b]indol]-2-one] is a potent, fast-acting, schizonticidal agent being developed for the treatment of malaria. After oral dosing of KAE609 to rats
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:670-673
The proton exchange reaction was applied to the preparation of stable isotope-labeled LCQ908. For this synthesis, a suitable intermediate with protons alpha to a carbonyl group was first subjected to the H-D exchange reaction; subsequent coupling of
Autor:
Katharyn J. Affeldt, Ry R. Forseth, Saori Amaike, Frank C. Schroeder, Daniel Schwenk, Dirk Hoffmeister, Nancy P. Keller
Publikováno v:
Angewandte Chemie. 125:1632-1636
Publikováno v:
ChemBioChem. 13:2521-2526
Biosynthesis of the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus involves the closure of a pair of enethiols to a cyclic disulfide. We have shown that the dithiol oxidase HlmI is responsible for the disulfide formation and this
Autor:
Ry R Forseth, Alexandre Catoire, Tapan Ray, Jin Zhang, Handan He, James B. Mangold, Su-Er W Huskey, Zhigang Jian, Hongmei Li, Jimmy Flarakos
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(10)
Identification of polar metabolites of drug candidates during development is often challenging. Several prominent polar metabolites of 2-amino-1-(2-(4-fluorophenyl)-3-((4-fluorophenyl)amino)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)etha
Autor:
John R. Heemstra, Wei Jiang, Frank C. Schroeder, Ry R. Forseth, Karl J. Hale, Soraya Manaviazar, Christopher S. Neumann, Christopher T. Walsh
Publikováno v:
Biochemistry
Kutznerides 2 and 8 of the cyclic hexadepsipeptide family of antifungal natural products from the soil actinomycete Kutzneria sp. 744 contain two sets of chlorinated residues, a 6,7-dichlorohexahydropyrroloindole moiety derived from dichlorotryptopha
Autor:
Frank C. Schroeder, Ry R. Forseth, Relebohile Sekonyela, Jonathan M. Palmer, Jin Woo Bok, Nancy P. Keller, Erwin Berthier, Sachin Jain
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62591 (2013)
PLoS ONE
PLoS ONE
Dimeric basic leucine zipper (bZIP) proteins are conserved transcriptional enhancers found in all eukaryotes. A recently reported and novel function for bZIPs is association of these proteins with secondary metabolite production in filamentous fungi.
Autor:
Saori Amaike, Katharyn J. Affeldt, Ry R. Forseth, Daniel Schwenk, Nancy P. Keller, Dirk Hoffmeister, Frank C. Schroeder
Publikováno v:
Angewandte Chemie (International ed. in English). 52(5)
Fungi are among the most prolific sources of pharmacologically relevant natural products.1 This large diversity of fungal small molecules serves important functions in fungal ecology, for example as virulence factors and as chemical defense agents. H
Autor:
Ry R. Forseth, Frank C. Schroeder
Publikováno v:
Fungal Secondary Metabolism ISBN: 9781627031219
For many fungi the number of known secondary metabolites is surprisingly small compared to the -astonishingly large number of terpene cyclase, polyketide synthase (PKS), and non-ribosomal peptide synthetase (NRPS) secondary metabolite gene clusters f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd57d8657f4fd34dee4765924add58f7
https://doi.org/10.1007/978-1-62703-122-6_15
https://doi.org/10.1007/978-1-62703-122-6_15