Abstract P1-10-15: Development of humanized anti-CD47 monoclonal antibodies with differentiated functional profiles

Autor: Pamela T. Manning, Robyn J Puro, S Chanda, RW Karr, Benjamin J. Capoccia, Michael J. Donio, Ronald R. Hiebsch, K. J. M. Liu, K Crowley

Publikováno v: Cancer Research. 78:P1-10

CD47 is a cell surface transmembrane protein that binds to signal regulatory protein alpha (SIRPα) on macrophages and results in a “don't eat me” signal that inhibits phagocytosis. Breast cancer cells, both primary and metastatic, frequently ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35c4cf714ebedd6fb356f06123e19d58
https://doi.org/10.1158/1538-7445.sabcs17-p1-10-15

Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding.

Autor: Puro RJ; Arch Oncology, Inc., St. Louis, Missouri., Bouchlaka MN; Arch Oncology, Inc., St. Louis, Missouri., Hiebsch RR; Arch Oncology, Inc., St. Louis, Missouri., Capoccia BJ; Arch Oncology, Inc., St. Louis, Missouri., Donio MJ; Arch Oncology, Inc., St. Louis, Missouri., Manning PT; Arch Oncology, Inc., St. Louis, Missouri., Frazier WA; Arch Oncology, Inc., St. Louis, Missouri., Karr RW; Arch Oncology, Inc., St. Louis, Missouri., Pereira DS; Arch Oncology, Inc., St. Louis, Missouri. dpereira@archoncology.com.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2020 Mar; Vol. 19 (3), pp. 835-846. Date of Electronic Publication: 2019 Dec 26.

CTLA-4-Fc treatment of ongoing EAE improves recovery, but has no effect upon relapse rate. Implications for the mechanisms involved in disease perpetuation.

Autor: Cross AH; Department of Neurology and Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA., San M, Keeling RM, Karr RW

Publikováno v: Journal of neuroimmunology [J Neuroimmunol] 1999 May 03; Vol. 96 (2), pp. 144-7.

HPRT mutant T-cell lines from multiple sclerosis patients recognize myelin proteolipid protein peptides.

Autor: Trotter JL; Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA. trotterj@neuro.wustl.edu, Damico CA, Cross AH, Pelfrey CM, Karr RW, Fu XT, McFarland HF

Publikováno v: Journal of neuroimmunology [J Neuroimmunol] 1997 May; Vol. 75 (1-2), pp. 95-103.

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

Autor: Molina H; Department of Internal Medicine and Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Holers VM, Li B, Fung Y, Mariathasan S, Goellner J, Strauss-Schoenberger J, Karr RW, Chaplin DD

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1996 Apr 16; Vol. 93 (8), pp. 3357-61.