Výsledky vyhledávání - "Ruzzo Walter L"

Akademický článek

A Regression-based K nearest neighbor algorithm for gene function prediction from heterogeneous data

Autor: Ruzzo Walter L, Yao Zizhen

Publikováno v: BMC Bioinformatics, Vol 7, Iss Suppl 1, p S11 (2006)

Abstract Background As a variety of functional genomic and proteomic techniques become available, there is an increasing need for functional analysis methodologies that integrate heterogeneous data sources. Methods In this paper, we address this issu

Externí odkaz: https://doaj.org/article/07b8dc7a31d6457fb3b7ac0fe913891a

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Akademický článek

Transcripts with in silico predicted RNA structure are enriched everywhere in the mouse brain

Autor: Seemann Stefan E, Sunkin Susan M, Hawrylycz Michael J, Ruzzo Walter L, Gorodkin Jan

Publikováno v: BMC Genomics, Vol 13, Iss 1, p 214 (2012)

Abstract Background Post-transcriptional control of gene expression is mostly conducted by specific elements in untranslated regions (UTRs) of mRNAs, in collaboration with specific binding proteins and RNAs. In several well characterized cases, these

Externí odkaz: https://doaj.org/article/b0560b8d25524384bac23aada47e3748

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Akademický článek

How accurately is ncRNA aligned within whole-genome multiple alignments?

Autor: Ruzzo Walter L, Wang Adrienne X, Tompa Martin

Publikováno v: BMC Bioinformatics, Vol 8, Iss 1, p 417 (2007)

Abstract Background Multiple alignment of homologous DNA sequences is of great interest to biologists since it provides a window into evolutionary processes. At present, the accuracy of whole-genome multiple alignments, particularly in noncoding regi

Externí odkaz: https://doaj.org/article/6245773573104e1fac49c4235603bf4e

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Akademický článek

A Marfan syndrome gene expression phenotype in cultured skin fibroblasts

Autor: Emond Mary, Morale Cecile Z, Ruzzo Walter L, Jaeger Jochen C, Yao Zizhen, Francke Uta, Milewicz Dianna M, Schwartz Stephen M, Mulvihill Eileen R

Publikováno v: BMC Genomics, Vol 8, Iss 1, p 319 (2007)

Abstract Background Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in the fibrillin-1 gene. This syndrome constitutes a significant identifiable subtype of aortic aneurysmal disease, accounting for over 5% of asce

Externí odkaz: https://doaj.org/article/3bf2061c0fa642af88fad0bcff320adb

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FPGA Acceleration of Short Read Alignment

Autor: McVicar, Nathaniel, Hoshino, Akina, La Torre, Anna, Reh, Thomas A., Ruzzo, Walter L., Hauck, Scott

Aligning millions of short DNA or RNA reads, of 75 to 250 base pairs each, to a reference genome is a significant computation problem in bioinformatics. We present a flexible and fast FPGA-based short read alignment tool. Our aligner makes use of the

Externí odkaz: http://arxiv.org/abs/1805.00106

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Compression of next-generation sequencing reads aided by highly efficient de novo assembly

Autor: Jones, Daniel C., Ruzzo, Walter L., Peng, Xinxia, Katze, Michael G.

We present Quip, a lossless compression algorithm for next-generation sequencing data in the FASTQ and SAM/BAM formats. In addition to implementing reference-based compression, we have developed, to our knowledge, the first assembly-based compressor,

Externí odkaz: http://arxiv.org/abs/1207.2424

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