Dictyostelium discoideum nucleoside diphosphate kinase C plays a negative regulatory role in phagocytosis, macropinocytosis and exocytosis.

Autor: Sarah J Annesley, Ruzica Bago, Maja Herak Bosnar, Vedrana Filic, Maja Marinović, Igor Weber, Anil Mehta, Paul R Fisher

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26024 (2011)

Nucleoside diphosphate kinases (NDPKs) are ubiquitous phosphotransfer enzymes responsible for producing most of the nucleoside triphosphates except for ATP. This role is important for the synthesis of nucleic acids and proteins and the metabolism of

Externí odkaz: https://doaj.org/article/f793633f120c44b0aa47fee4dac29834

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Autor: Ludmila Prudkin, José Baselga, Amelia Barnett, Leire Arreal, María L. Martínez-Chantar, Alejo Efeyan, Arkaitz Carracedo, Elena Castro, Violeta Serra, Yinan Zhang, David Pirman, Ylenia Cendon, Teresa Macarulla, Patricia Zúñiga-García, Rosa Farràs, José M. Mato, Rosa Barrio, Inés Cristina Torres, Julen Tomás-Cortázar, Juan Anguita, Juan M. Falcón-Pérez, Alfredo Caro-Maldonado, Gina Lein, Josep Tabernero, Ana Loizaga-Iriarte, Amaia Zabala-Letona, James D. Sutherland, Jose Jimenez, David Olmos, Mikel Azkargorta, Naiara Beraza, Carlos Cordon-Cardo, Pilar Sanchez-Mosquera, Ajinkya Revandkar, Paolo Nuciforo, Felix Elortza, Ruzica Bago, Isabel Lacasa-Viscasillas, Stuart Murray, Miguel Unda, Natalia Martín-Martín, Verónica Torrano, Mireia Castillo-Martin, Ana M. Aransay, Itziar Fernández-Domínguez, Antonio Gentilella, Sebastiaan M. Van Liempd, Brendan D. Manning, Aitziber Ugalde-Olano, Pilar Ximénez-Embún, Andrea Alimonti, Lorea Valcarcel-Jimenez, Javier Muñoz, Sonia Fernández-Ruiz, Diana Cabrera, Amaia Arruabarrena-Aristorena, Michelle Clasquin, Katya Marjon, Phong Quang, Marco Piva, Ana R. Cortazar, George Thomas, Kevin R Marks, Ianire Astobiza

Publikováno v: NATURE
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Nature, vol. 547, no. 7661, pp. 109-113
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c46ce2fd07391467ea991e3f352e43c
https://ddd.uab.cat/pub/artpub/2017/pmc_28658205/pmc_28658205.pdf

The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses

Autor: Linda Gräßel, Laura Aline Fast, Konstanze D. Scheffer, Fatima Boukhallouk, Gilles A. Spoden, Stefan Tenzer, Klaus Boller, Ruzica Bago, Sundaresan Rajesh, Michael Overduin, Fedor Berditchevski, Luise Florin

Publikováno v: Scientific Reports

Human papillomaviruses enter host cells via a clathrin-independent endocytic pathway involving tetraspanin proteins. However, post-endocytic trafficking required for virus capsid disassembly remains unclear. Here we demonstrate that the early traffic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39f59ce886fe30b7ddfbe4357ef3017
https://pubmed.ncbi.nlm.nih.gov/27578500

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

Autor: Haley Ellis, Maurizio Scaltriti, Pau Castel, Ruzica Bago, Edi Brogi, José Baselga, Srinivasaraghavan Kannan, Dario R. Alessi, Eneda Toska, F. Javier Carmona, Sarat Chandarlapaty, Chandra S. Verma, Maura N. Dickler, Pedram Razavi

Publikováno v: Cancer Cell

Summary PIK3CA, which encodes the p110α subunit of PI3K, is frequently mutated and oncogenic in breast cancer. PI3Kα inhibitors are in clinical development and despite promising early clinical activity, intrinsic resistance is frequent among patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540d90f8802cb5fa371921abfadd5bbd
https://pubmed.ncbi.nlm.nih.gov/27451907

Abstract 2107: PDK1 blockade overcomes intrinsic resistance to PI3Kα inhibition

Autor: F. Javier Carmona, Eneda Toska, Sarat Chandarlapaty, Chandra S. Verma, José Baselga, Kannan Srinivasaraghavan, Haley Ellis, Maura N. Dickler, Ruzica Bago, Edi Brogi, Pedram Razavi, Pau Castel, Maurizio Scaltriti, Dario R. Alessi

Publikováno v: Cancer Research. 76:2107-2107

Somatic mutations in PIK3CA, the gene encoding the α isoform of PI3K (p110α), are frequent in breast cancer. These mutations lead to constitutive activation of the PI3K/AKT/mTORC1 pathway and are a potential therapeutic target. Despite the encourag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f323c3603ca68645ee97493bdaa5d844
https://doi.org/10.1158/1538-7445.am2016-2107