Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ruzanna A Ovsepyan"'
Autor:
Vladimir N Kolyadko, Sofya V Lushchekina, Tatiana A Vuimo, Stepan S Surov, Ruzanna A Ovsepyan, Vera A Korneeva, Ivan I Vorobiev, Nadezhda A Orlova, Leonid Minakhin, Konstantin Kuznedelov, Konstantin V Severinov, Fazoil I Ataullakhanov, Mikhail A Panteleev
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144940 (2015)
Factor XIIa (fXIIa) is a serine protease that triggers the coagulation contact pathway and plays a role in thrombosis. Because it interferes with coagulation testing, the need to inhibit fXIIa exists in many cases. Infestin-4 (Inf4) is a Kazal-type i
Externí odkaz:
https://doaj.org/article/a3e33141cf504a309b6f154e7fb7c5c9
Autor:
Nico Bückreiß, Mikhail A. Panteleev, Maximilian Barth, Benjamin M Wenzel, Gregor A Kastner, Antti Poso, Svetlana A. Kalinina, Hans-Ulrich Humpf, Ruzanna A. Ovsepyan, Uwe Karst, Lukas Imberg, Marvin Korff, Dmitrii V. Kalinin, Constantin G. Daniliuc, Kirill R Butov, Matthias Lehr, Jonas M. Will, Gerd Bendas, Torsten Steinmetzer
Publikováno v:
Journal of Medicinal Chemistry. 63:13159-13186
We herein report the conventional and microscale parallel synthesis of selective inhibitors of human blood coagulation factor XIIa and thrombin exhibiting a 1,2,4-triazol-5-amine scaffold. Structural variations of this scaffold allowed identifying de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a122dda2d0c15b0636be36a9342770d6
https://doi.org/10.1021/acs.jmedchem.0c01635
https://doi.org/10.1021/acs.jmedchem.0c01635
Autor:
Marvin, Korff, Lukas, Imberg, Jonas M, Will, Nico, Bückreiß, Svetlana A, Kalinina, Benjamin M, Wenzel, Gregor A, Kastner, Constantin G, Daniliuc, Maximilian, Barth, Ruzanna A, Ovsepyan, Kirill R, Butov, Hans-Ulrich, Humpf, Matthias, Lehr, Mikhail A, Panteleev, Antti, Poso, Uwe, Karst, Torsten, Steinmetzer, Gerd, Bendas, Dmitrii V, Kalinin
Publikováno v:
Journal of medicinal chemistry. 63(21)
We herein report the conventional and microscale parallel synthesis of selective inhibitors of human blood coagulation factor XIIa and thrombin exhibiting a 1,2,4-triazol-5-amine scaffold. Structural variations of this scaffold allowed identifying de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::236ea7e65cf60370817ad687af9e4c77
https://pubmed.ncbi.nlm.nih.gov/33089691
https://pubmed.ncbi.nlm.nih.gov/33089691
Autor:
Stepan S. Surov, Ruzanna A. Ovsepyan, Fazoil I. Ataullakhanov, Maxim M. Lutsenko, Ilya I. Serebriyskiy, Elena I. Sinauridze, Tatiana A. Vuimo, Natalia G. Korotina, Ivan D. Tarandovskiy, Alexander L. Sokolov
Publikováno v:
Talanta. 180:282-291
The actual coagulation status may be reliably measured using only highly sensitive global functional tests; however, they are not numerous and all of them have disadvantages. Thrombodynamics (TD), a novel global coagulation test, is sensitive to hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab933648fa5d34ba310ef8664ae0eca
https://doi.org/10.1016/j.talanta.2017.12.055
https://doi.org/10.1016/j.talanta.2017.12.055
Autor:
Irina G. Rekhtina, Dorzho B. Ayusheev, Ruzanna A. Ovsepyan, Elena N. Lipets, Elena I. Sinauridze, Fazoil I. Ataullakhanov, Alex I. Bernakevich, Irina V. Gribkova
Publikováno v:
Scientific Reports
A new oral anticoagulant, dabigatran etexilate (DE, a prodrug of direct thrombin inhibitor (DTI) dabigatran), has been used clinically to prevent thrombosis. The assessment of dabigatran efficiency is necessary in some clinical cases, such as renal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26079755ec20a349299bd49af1bb42af
https://doi.org/10.1038/srep29242
https://doi.org/10.1038/srep29242
Autor:
Tatiana A. Vuimo, Fazoil I. Ataullakhanov, Natalia P. Soshitova, Ruzanna A. Ovsepyan, Stepan S. Surov, Mikhail A. Panteleev, Claude Negrier, Natalia M. Dashkevich
Publikováno v:
Thrombosis research. 133(3)
Introduction Standardization of pre-analytical conditions is the obligatory step for all potential diagnostic tests. Spatial clot growth (Thrombodynamics) is a new global hemostasis assay that considers spatial organization of coagulation. The princi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0ff19bfdc10b958f98adee441deb93
https://pubmed.ncbi.nlm.nih.gov/24369827
https://pubmed.ncbi.nlm.nih.gov/24369827
Autor:
Elena N. Lipets, Tatiana V. Vuimo, Fazoil I. Ataullakhanov, Ruzanna A. Ovsepyan, Stepan S. Surov, Anna N. Balandina, Elena A. Seregina, Natalia P. Soshitova, Claude Negrier, Mikhail A. Panteleev, Natalia M. Dashkevich
Publikováno v:
Blood. 120:4393-4393
Abstract 4393 Introduction Thrombodynamics is a novel global coagulation assay based on spatial separation of clotting activation and propagation. In this assay fibrin clot grows from the TF-coated surface in a thin layer of non-stirred plasma. Clot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f752cc0b4ebb383812e8f12702add97b
https://doi.org/10.1182/blood.v120.21.4393.4393
https://doi.org/10.1182/blood.v120.21.4393.4393
Autor:
Konstantin Severinov, Ivan I. Vorobiev, Nadezhda A. Orlova, Vera A. Korneeva, Mikhail A. Panteleev, Tatiana A. Vuimo, Sofya V. Lushchekina, Konstantin Kuznedelov, Stepan S. Surov, Fazoil I. Ataullakhanov, Leonid Minakhin, Vladimir N. Kolyadko, Ruzanna A. Ovsepyan
Publikováno v:
BASE-Bielefeld Academic Search Engine
PLoS ONE, Vol 10, Iss 12, p e0144940 (2015)
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0144940 (2015)
PLoS ONE
Factor XIIa (fXIIa) is a serine protease that triggers the coagulation contact pathway and plays a role in thrombosis. Because it interferes with coagulation testing, the need to inhibit fXIIa exists in many cases. Infestin-4 (Inf4) is a Kazal-type i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92886cb2ab299574b86254a6dce2612c
https://doi.org/10.1371/journal.pone.0144940
https://doi.org/10.1371/journal.pone.0144940
