Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ruya Liu"'
Autor:
Vinny Negi, Jeongkyung Lee, Varun Mandi, Joseph Danvers, Ruya Liu, Eliana M. Perez-Garcia, Feng Li, Rajaganapati Jagannathan, Ping Yang, Domenic Filingeri, Amit Kumar, Ke Ma, Mousumi Moulik, Vijay K. Yechoor
Publikováno v:
Cells, Vol 13, Iss 13, p 1108 (2024)
Cytokine-induced β-cell apoptosis is a major pathogenic mechanism in type 1 diabetes (T1D). Despite significant advances in understanding its underlying mechanisms, few drugs have been translated to protect β-cells in T1D. Epigenetic modulators suc
Externí odkaz:
https://doaj.org/article/4352056514b0436c91865b24cc85dd4b
Autor:
Feng Li, Ruya Liu, Vinny Negi, Ping Yang, Jeongkyung Lee, Rajaganapathi Jagannathan, Mousumi Moulik, Vijay K. Yechoor
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111904- (2023)
Summary: TEAD1 and the mammalian Hippo pathway regulate cellular proliferation and function, though their regulatory function in β cells remains poorly characterized. In this study, we demonstrate that while β cell-specific TEAD1 deletion results i
Externí odkaz:
https://doaj.org/article/58507afec47146c5b6c53a63b91d1ced
Autor:
Ruya Liu, Rajaganapathi Jagannathan, Feng Li, Jeongkyung Lee, Nikhil Balasubramanyam, Byung S Kim, Ping Yang, Vijay K Yechoor, Mousumi Moulik
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212017 (2019)
Adult heart size is determined predominantly by the cardiomyocyte number and size. The cardiomyocyte number is determined primarily in the embryonic and perinatal period, as adult cardiomyocyte proliferation is restricted in comparison to that seen d
Externí odkaz:
https://doaj.org/article/95b43d1709ae4f218ddab65b196a37bf
Publikováno v:
Journal of molecular cell biology.
The morphological transformation of adipogenic progenitors into mature adipocytes requires dissolution of cytoskeleton driven by progressive loss of MRTF-SRF activity. Circadian clock confers temporal control in adipogenic differentiation, and MRTF-S
Publikováno v:
Diabetes. 71
The circadian clock confers temporal regulation in metabolism, and its disruption leads to obesity and insulin resistance. In the current study, we identify that the opposing circadian clock regulators, transcription activator Bmal1 and its repressor
Publikováno v:
Diabetes. 71
β-cell mass is significantly reduced especially in the late stage of diabetes. Hence, increasing β-cell proliferation to increase β-cell mass remains a desirable goal for diabetes treatment. The mechanisms that regulate β cell proliferation and c
Autor:
JEONGKYUNG LEE, RUYA LIU, FENG LI, VINNY NEGI, RAJAGANAPATHI JAGANNATHAN, MARK HUISING, KE MA, BEN SHIH, MOUSUMI MOULIK, VIJAY YECHOOR
Publikováno v:
Diabetes. 71
The transcriptional factor, Tead1, mediates the transcriptional output of the Hippo pathway. Tead1 activates the transcription of downstream genes including many cell cycle promoting genes that lead to cell proliferation in many tissues, but its role
Autor:
Ping Yang, Rajaganapathi Jagannathan, Jeongkyung Lee, Lingfei Sun, Eliana Melissa Perez-Garcia, Ruya Liu, Sruti Shiva, Vinny Negi, Mousumi Moulik, Feng Li, Vijay Yechoor
Publikováno v:
Am J Physiol Heart Circ Physiol
Mitochondrial dysfunction occurs in most forms of heart failure. We have previously reported that Tead1, the transcriptional effector of Hippo pathway, is critical for maintaining adult cardiomyocyte function, and its deletion in adult heart results
Publikováno v:
Diabetes. 70
The adipogenic progenitor transformation into mature adipocytes requires dissolution of intracellular actin cytoskeleton, and the cytoskeleton-MRTF/SRF signaling blocks adipogenesis. The circadian clock confers temporal control in metabolism, with ti
Autor:
Ping Yang, Vijay Yechoor, Feng Li, Negi, Eliana Melissa Perez-Garcia, Ruya Liu, Rita Bottino, Mousumi Moulik, Janet S. Lee, Ke Ma, Rajaganapati Jagannathan
Cytokine induced β-cell apoptosis is the major pathogenic mechanism in type 1 diabetes (T1D). Despite significant advances in understanding underlying mechanisms, few drugs have been translated to protect β-cells in T1D. Epigenetic modulators such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaf37cca886bb24d4e57a4d318cf98a0
https://doi.org/10.1101/2020.11.05.363408
https://doi.org/10.1101/2020.11.05.363408