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Senescent cells re-engineered to express soluble programmed death receptor-1 for inhibiting programmed death receptor-1/programmed death ligand-1 as a vaccination approach against breast cancer

Autor: Zehong Chen, Ruxiong Su, Nan Lai, Zike Yang, Shijun Kang, Lieting Feng, Kang Hu

Publikováno v: Cancer science. 109(6)

Various types of vaccines have been proposed as approaches for prevention or delay of the onset of cancer by boosting the endogenous immune system. We previously developed a senescent-cell-based vaccine, induced by radiation and veliparib, as a preve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abab105f9054c18158eceb28ab7a746f
https://pubmed.ncbi.nlm.nih.gov/29675979

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sPD-1过表达增强衰老肿瘤细胞疫苗抗小鼠乳腺癌作用

Autor: Zehong, Chen, Huiwen, Lin, Kang, Hu, Ruxiong, Su, Nan, Lai, Zike, Yang, Shijun, Kang

OBJECTIVE: To investigate whether soluble PD-1 overexpression in 4T1 senescence tumor cells enhances the antitumor effect of senescence tumor cell vaccine (STCV) against breast tumor cells in a tumor-bearing mouse model. METHODS: 4T1 cells were treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5249e40a956d942bc5a6d2e0d48b3c7e
https://europepmc.org/articles/PMC6765615/

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