Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ruxi Qi"'
Autor:
Yanqun Wang, An Yan, Deyong Song, Maoqin Duan, Chuangchuang Dong, Jiantao Chen, Zihe Jiang, Yuanzhu Gao, Muding Rao, Jianxia Feng, Zhaoyong Zhang, Ruxi Qi, Xiaomin Ma, Hong Liu, Beibei Yu, Qiaoping Wang, Mengqi Zong, Jie Jiao, Pingping Xing, Rongrong Pan, Dan Li, Juxue Xiao, Junbo Sun, Ying Li, Linfeng Zhang, Zhenduo Shen, Baiping Sun, Yanyan Zhao, Lu Zhang, Jun Dai, Jingxian Zhao, Lan Wang, Changlin Dou, Zheng Liu, Jincun Zhao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The constant emergence of SARS-CoV-2 variants continues to impair the efficacy of existing neutralizing antibodies, especially XBB.1.5 and EG.5, which showed exceptional immune evasion properties. Here, we identify a highly conserved neutral
Externí odkaz:
https://doaj.org/article/c33908424c5646a8b6688faee41eaca1
Autor:
Yanqun Wang, An Yan, Deyong Song, Chuangchuang Dong, Muding Rao, Yuanzhu Gao, Ruxi Qi, Xiaomin Ma, Qiaoping Wang, Hongguang Xu, Hong Liu, Jing Han, Maoqin Duan, Shuo Liu, Xiaoping Yu, Mengqi Zong, Jianxia Feng, Jie Jiao, Huimin Zhang, Min Li, Beibei Yu, Yanxia Wang, Fanhao Meng, Xiaodan Ni, Ying Li, Zhenduo Shen, Baiping Sun, Xin Shao, Haifeng Zhao, Yanyan Zhao, Rui Li, Yanan Zhang, Guangying Du, Jun Lu, Chunna You, Hua Jiang, Lu Zhang, Lan Wang, Changlin Dou, Zheng Liu, Jincun Zhao
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new broad-spectrum mAbs. Here, we report the isolation and analysis of tw
Externí odkaz:
https://doaj.org/article/b38531d441f14db695079f6108b97685
Autor:
Aojie Wang, Feng Zhou, Congcong Liu, Dongsheng Gao, Ruxi Qi, Yiheng Yin, Sheng Liu, Yuanzhu Gao, Lutang Fu, Yinhe Xia, Yawei Xu, Chuanqing Wang, Zheng Liu
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Getah virus (GETV), a member of the genus alphavirus, is a mosquito-borne pathogen that can cause pyrexia and reproductive losses in animals. Although antibodies to GETV have been found in over 10% of healthy people, there are no reports of
Externí odkaz:
https://doaj.org/article/f57e5e3ef79547abad6212a6982accfa
Autor:
Yingjun Li, Yongjun Huang, Huimin Cheng, Fang Xu, Ruxi Qi, Botao Dai, Yujian Yang, Zhengchao Tu, Lijie Peng, Zhang Zhang
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The combination of histone deacetylase inhibitor and BRAF inhibitor (BRAFi) has been shown to enhance the antineoplastic effect and reduce the progress of BRAFi resistance. In this study, a series of (thiazol-5-yl)pyrimidin-2-yl)amino)-N-hydroxyalkan
Externí odkaz:
https://doaj.org/article/6a7b82a61177447a944213ed46765845
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2018)
The Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA) approach has been widely applied as an efficient and reliable free energy simulation method to model molecular recognition, such as for protein-ligand binding interactions. In this revie
Externí odkaz:
https://doaj.org/article/b20434ef92aa4ef28370f99683978855
Autor:
Xiong Chen, Shanping Ji, Zheyi Liu, Xiao Yuan, Congsheng Xu, Ruxi Qi, An He, Heng Zhao, Haiping Song, Chunlei Xiao, Weina Gao, Peng R. Chen, Ray Luo, Pengfei Li, Fangjun Wang, Xueming Yang, Ruijun Tian
Publikováno v:
Cell chemical biology, vol 29, iss 6
Identification of the tyrosine phosphorylation (pY)-dependent interactome of immune co-receptors is crucial for understanding signal pathways involved in immunotherapy. However, identifying the motif-specific interactome for each pY commonly found on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85849e6b71ece05a1df0d14273ed9a7c
https://escholarship.org/uc/item/5gk8t8qs
https://escholarship.org/uc/item/5gk8t8qs
Autor:
Yujian Yang, Qiuchun Yu, Lean Hu, Botao Dai, Ruxi Qi, Yu Chang, Qingwen Zhang, Zhang Zhang, Yingjun Li, Xumu Zhang
Publikováno v:
European journal of medicinal chemistry. 244
Cephalotaxine-type alkaloids (CTAs), represented by homoharringtonine (HHT, 1), display potent efficacy against different types of leukemia cells. In this study, a method for hydrogenation of β-substituted itaconic acid monoesters with chiral Ru[DTB
Autor:
Han Han, Hiroki J. Nakaoka, Line Hofmann, Jeff Jiajing Zhou, Clinton Yu, Lisha Zeng, Junyu Nan, Gayoung Seo, Rebecca Elizabeth Vargas, Bing Yang, Ruxi Qi, Lee Bardwell, Dmitry A. Fishman, Ken W. Y. Cho, Lan Huang, Ray Luo, Rahul Warrior, Wenqi Wang
Publikováno v:
Nat Cell Biol
Nature cell biology, vol 24, iss 1
Nature cell biology, vol 24, iss 1
Heavy metals are both integral parts of cells and environmental toxicants, and their deregulation is associated with severe cellular dysfunction and various diseases. Here we show that the Hippo pathway plays a critical role in regulating heavy metal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc72fa5595c58c2af5bb74b636342fb0
https://europepmc.org/articles/PMC9022944/
https://europepmc.org/articles/PMC9022944/
Autor:
John H Dupius, Peiyi Wang, Ruxi Qi, Xiaoli Zhao, Jenny Jingxin Tian, Xiuyuan Ou, Jiaxin Chen, Xiaomin Ma, Dehai Liang, Shenlin Wang, Rickey Y. Yada, Zhaohui Qian
Publikováno v:
The Journal of Biological Chemistry
Various plants use antimicrobial proteins/peptides as a means to resist phytopathogens. In the potato, Solanum tuberosum, the plant-specific insert (PSI) domain of an aspartic protease performs this role by disrupting phytopathogen plasma membranes.
Heparin remodels the microtubule-binding repeat R3 of Tau protein towards fibril-prone conformations
Autor:
Qin Qiao, Qingwen Zhang, Xuewei Dong, Fangying Li, Guanghong Wei, Jiaqian Wan, Xuhua Li, Ruxi Qi
Publikováno v:
Physical chemistry chemical physics : PCCP. 23(36)
Abnormal aggregation of proteins into pathological amyloid fibrils is implicated in a wide range of devastating human neurodegenerative diseases. Intracellular fibrillary inclusions formed by Tau protein are characterized as the hallmark of tauopathi