Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Ruurdtje Hoekstra"'
Autor:
Martien van Wenum, Philipp Treskes, Aziza A.A. Adam, Vincent. A van der Mark, Aldo Jongejan, Perry D. Moerland, Thomas M. van Gulik, Ronald P.J. Oude Elferink, Robert A.F.M. Chamuleau, Ruurdtje Hoekstra
Publikováno v:
Cellular Physiology and Biochemistry, Vol 48, Iss 5, Pp 2189-2204 (2018)
Background/Aims: For applicability of cell-based therapies aimed at the treatment of liver failure, such as bioartificial livers (BALs) and hepatocyte transplantation, it is essential that the applied hepatocytes tolerate exposure to the patient plas
Externí odkaz:
https://doaj.org/article/d395e327d4e34c6f877296ef3ed34f46
Autor:
Aziza A A Adam, Vincent A van der Mark, Joanne M Donkers, Manon E Wildenberg, Ronald P J Oude Elferink, Robert A F M Chamuleau, Ruurdtje Hoekstra
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0193664 (2018)
Practice-changing culturing techniques of hepatocytes are highly required to increase their differentiation. Previously, we found that human liver cell lines HepaRG and C3A acquire higher functionality and increased mitochondrial biogenesis when cult
Externí odkaz:
https://doaj.org/article/dda135b9f4ac477fa76ca8c842d09a26
Autor:
Ebtisam El Filali, Suzanne Duijst, Johan K Hiralall, Nicolas Legrand, Thomas van Gulik, Ruurdtje Hoekstra, Jurgen Seppen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Possible risks and lack of donor livers limit application of liver transplantation. Liver cell transplantation is, at this moment, not a feasible alternative because engraftment in the liver is poor. Furthermore, there is also shortage of cells suita
Externí odkaz:
https://doaj.org/article/1dedab3c2dd3457ea53bb391aac89581
Autor:
Geert A A Nibourg, Robert A F M Chamuleau, Tessa V van der Hoeven, Martinus A W Maas, An F C Ruiter, Wouter H Lamers, Ronald P J Oude Elferink, Thomas M van Gulik, Ruurdtje Hoekstra
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38778 (2012)
A major roadblock to the application of bioartificial livers is the need for a human liver cell line that displays a high and broad level of hepatic functionality. The human bipotent liver progenitor cell line HepaRG is a promising candidate in this
Externí odkaz:
https://doaj.org/article/6c1861603e0d4671ab5f49e67411a5eb
Autor:
Tanja Deurholt, Lysbeth Ten Bloemendaal, Aniska A. Chhatta, Albert C. W. A. Van Wijk, Kees Weijer, Jurgen Seppen, Ronald P. J. Oude Elferink, Robert A. F. M. Chamuleau, Ruurdtje Hoekstra
Publikováno v:
Cell Transplantation, Vol 15 (2006)
Mature human hepatocytes are not suitable for large-scale in vitro applications that rely on hepatocyte function, due to their limited availability and insufficient proliferation capacity in vitro. In contrast, human fetal liver cells (HFLC) can be e
Externí odkaz:
https://doaj.org/article/cb20d7667db94b94bda82a82a84d99e2
Autor:
Ruurdtje Hoekstra, Tanja Deurholt, Lysbeth ten Bloemendaal, Mireille Desille, Albert C. W. A. van Wijk, Bruno Clement, Ronald P. J. Oude Elferink, Thomas M. van Gulik, Robert A. F. M. Chamuleau
Publikováno v:
Cell Transplantation, Vol 15 (2006)
In vitro applications of human hepatocytes, such as bioartificial livers and toxicity assays, require thoroughly testing of human cell lines prior to using them as alternative cell sources. The reversibly immortalized NKNT-3 cell line was reported to
Externí odkaz:
https://doaj.org/article/f187ca16edaf4aaebad66781684e81ce
Autor:
Megan J, Reiniers, Lianne R, de Haan, Laurens F, Reeskamp, Mans, Broekgaarden, Ruurdtje, Hoekstra, Rowan F, van Golen, Michal, Heger
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2451
Oxidative stress is a state that arises when the production of reactive transients overwhelms the cell's capacity to neutralize the oxidants and radicals. This state often coincides with the pathogenesis and perpetuation of numerous chronic diseases.
Autor:
Megan J. Reiniers, Lianne R. de Haan, Laurens F. Reeskamp, Mans Broekgaarden, Ruurdtje Hoekstra, Rowan F. van Golen, Michal Heger
Publikováno v:
Methods in Molecular Biology, 2451, 721-747
Methods in Molecular Biology, 721-747
STARTPAGE=721;ENDPAGE=747;TITLE=Methods in Molecular Biology
Methods in Molecular Biology ISBN: 9781071620984
Methods in Molecular Biology, 721-747
STARTPAGE=721;ENDPAGE=747;TITLE=Methods in Molecular Biology
Methods in Molecular Biology ISBN: 9781071620984
Oxidative stress is a state that arises when the production of reactive transients overwhelms the cell’s capacity to neutralize the oxidants and radicals. This state often coincides with the pathogenesis and perpetuation of numerous chronic disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f78f8501afc892bd61a6fa9a7b7ace8
https://pure.amc.nl/en/publications/optimal-use-of-27dichlorofluorescein-diacetate-in-cultured-hepatocytes(638e9f4b-f90b-461f-9f6b-e586828c9a67).html
https://pure.amc.nl/en/publications/optimal-use-of-27dichlorofluorescein-diacetate-in-cultured-hepatocytes(638e9f4b-f90b-461f-9f6b-e586828c9a67).html
Autor:
Ruby Lieshout, Chen Chen, Natalia Sánchez-Romero, Kerstin Schneeberger, Iris Pla Palacin, Louis C. Penning, Joery De Kock, Hans Clevers, Sabine A. Fuchs, Bart Spee, Monique E van Wolferen, Loes A Oosterhoff, Haaike Colemonts-Vroninks, Imre F. Schene, Ruurdtje Hoekstra, Pedro M. Baptista, Shicheng Ye, Luc J. W. van der Laan, Monique M A Verstegen, Gilles S van Tienderen, Frank G. van Steenbeek
Publikováno v:
Hepatology, 72(1), 257-270. John Wiley & Sons Ltd.
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Hepatology (Baltimore, Md.)
Hepatology
Hepatology. American Association for the Study of Liver Diseases (AASLD)
Hepatology (Baltimore, Md.), 72(1), 257-270. John Wiley and Sons Ltd
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Hepatology (Baltimore, Md.)
Hepatology
Hepatology. American Association for the Study of Liver Diseases (AASLD)
Hepatology (Baltimore, Md.), 72(1), 257-270. John Wiley and Sons Ltd
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Background and Aims: The gap between patients on transplant waiting lists and available donor organs is steadily increasing. Human organoids derived from leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)–positive adult stem cells r
Publikováno v:
Journal of Artificial Organs
End-stage liver failure is a condition of collapsing liver function with mortality rates up to 80. Liver transplantation is the only lifesaving therapy. There is an unmet need for therapy to extend the waiting time for liver transplantation or regene