Aggravation of experimental allergic encephalomyelitis (EAE) by administration of nitric oxide (NO) synthase inhibitors.

Autor: Ruuls, S. R.¹, Linden, S. Van Der¹, Sontrop, K.¹, Huitinga, L.¹, Dijkstra, C. D.¹

Publikováno v: Clinical & Experimental Immunology. Mar1996, Vol. 103 Issue 3, p467-474. 8p.

Beta-adrenoceptor-sensitive adenylate cyclase is inhibited by activation of mu-opioid receptors in rat striatal neurons

Autor: Van Vliet, B J, Ruuls, S R, Drukarch, B, Mulder, A H, Schoffelmeer, A N

Publikováno v: European Journal of Pharmacology, 195(2), 295-300. Elsevier
Van Vliet, B J, Ruuls, S R, Drukarch, B, Mulder, A H & Schoffelmeer, A N 1991, ' Beta-adrenoceptor-sensitive adenylate cyclase is inhibited by activation of mu-opioid receptors in rat striatal neurons ', European Journal of Pharmacology, vol. 195, no. 2, pp. 295-300 .

The beta-adrenoceptor-sensitive adenylate cyclase in primary cultures of rat striatal neurons was inhibited by opioids, unlike that in rat striatal slices. Isoprenaline (1 microM)-stimulated cyclic AMP production was dose dependently inhibited by the

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https://research.vumc.nl/en/publications/c6678ccb-3e69-48f7-8f38-c279b5520c73

Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

Autor: Ruuls SR; DNAX, 901 California Avenue, Palo Alto, CA 94304, USA., Hoek RM, Ngo VN, McNeil T, Lucian LA, Janatpour MJ, Körner H, Scheerens H, Hessel EM, Cyster JG, McEvoy LM, Sedgwick JD

Publikováno v: Immunity [Immunity] 2001 Oct; Vol. 15 (4), pp. 533-43.

Down-regulation of the macrophage lineage through interaction with OX2 (CD200).

Autor: Hoek RM; DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA., Ruuls SR, Murphy CA, Wright GJ, Goddard R, Zurawski SM, Blom B, Homola ME, Streit WJ, Brown MH, Barclay AN, Sedgwick JD

Publikováno v: Science (New York, N.Y.) [Science] 2000 Dec 01; Vol. 290 (5497), pp. 1768-71.

Discontinuation of treatment with IFN-beta leads to exacerbation of experimental autoimmune encephalomyelitis in Lewis rats. Rapid reversal of the antiproliferative activity of IFN-beta and excessive expansion of autoreactive T cells as disease promoting mechanisms.

Autor: van der Meide PH; Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands. meide@bprc.nl, de Labie MC, Ruuls SR, Groenestein RJ, Botman CA, Olsson T, Dijkstra CD

Publikováno v: Journal of neuroimmunology [J Neuroimmunol] 1998 Apr 01; Vol. 84 (1), pp. 14-23.