Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ruud C. Cox"'
Publikováno v:
Biochemistry. 38:6346-6351
We have synthesized a series of alpha-keto triglyceride analogues as inhibitors for the lipase from Staphylococcus hyicus (SHL). Hydrolysis at positions 1 and 2 was prevented by replacement of the ester bonds by nonhydrolyzable ether, carbamoyl, or a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f35251e9ec178ef0cc31f83daed815
https://doi.org/10.1021/bi982498b
https://doi.org/10.1021/bi982498b
Publikováno v:
"Protein Engineering, Design and Selection". 9:345-352
The effect of the substitution of the active site histidine 48 by the unnatural 1,2,4-triazole-3-alanine (TAA) amino acid analogue in porcine pancreas phospholipase A2 (PLA2) was studied. TAA was introduced biosynthetically using a his-auxotrophic Es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56fdac2bcef123ee476872df9716e2d1
https://doi.org/10.1093/protein/9.4.345
https://doi.org/10.1093/protein/9.4.345
Publikováno v:
European Journal of Biochemistry. 231:747-753
Porcine pancreatic phospholipase A2 (PLA2) was studied by site-directed mutagenesis. Arg53 and/or Lys56 were replaced by a methionine (R53M or K56M, respectively) in combination with the Tyr69-->Phe (Y69F) substitution. These substitutions improved t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d374534f08960b32773419c79fd7e1d2
https://doi.org/10.1111/j.1432-1033.1995.0747d.x
https://doi.org/10.1111/j.1432-1033.1995.0747d.x
Autor:
G.H. de Haas, J. De Vlieg, Bart C. Koops, H. T. W. M. Van Der Hijden, Maarten Robert Egmond, Hubertus M. Verheij, Ruud C. Cox, M. L. M. Mannesse
Publikováno v:
Biochemistry. 34:6400-6407
Triglyceride analogues were synthesized in which one of the primary acyl ester functions has been replaced by an alkyl group and the secondary acyl ester bond has been replaced by an acyl amino bond. The chain length at either position was varied, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98649888a11d3dfbbd5afe4d7bdf60bf
https://doi.org/10.1021/bi00019a020
https://doi.org/10.1021/bi00019a020
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1212:50-58
Two series of (R)-phospholipid analogues, each containing a n-propyl group at the C-1 position and various acylamino functions at the C-2 position have been synthesized and their inhibitory properties towards three mammalian pancreatic phospholipases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbc8f67220c083aa7d08fd1cd12409b
https://doi.org/10.1016/0005-2760(94)90188-0
https://doi.org/10.1016/0005-2760(94)90188-0
Autor:
Muriel D. van Kampen, Ruud C. Cox, Cristina M. Alves dos Santos, Jan-Willem F. A. Simons, Iban Ubarretxena-Belandia, Hubertus M. Verheij, Maarten R. Egmond
Publikováno v:
Biochemistry. 38(1)
In this study we have identified the presence of a high-affinity binding site for calcium in the lipase from Staphylococcus hyicus. By means of isothermal titration calorimetry we showed that the enzyme binds one calcium per molecule of enzyme with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed5dee4f3c510a896e8d4a59eb3f9e9
https://pubmed.ncbi.nlm.nih.gov/9890877
https://pubmed.ncbi.nlm.nih.gov/9890877
Autor:
Renne, Mike F, Bao, Xue, Hokken, Margriet WJ, Bierhuizen, Adolf S, Hermansson, Martin, Sprenger, Richard R, Ewing, Tom A, Ma, Xiao, Cox, Ruud C, Brouwers, Jos F, De Smet, Cedric H, Ejsing, Christer S, de Kroon, Anton IPM
Publikováno v:
EMBO Journal; Jan2022, Vol. 41 Issue 2, p1-16, 16p
Autor:
Kramer, R. Arjen1, Brandenburg, Klaus2, Vandeputte-Rutten, Lucy3, Werkhoven, Marjolein1, Gros, Piet3, Dekker, Niek1, Egmond, Maarten R1
Publikováno v:
European Journal of Biochemistry. Mar2002, Vol. 269 Issue 6, p1746-1752. 7p.
Autor:
Ubarretxena-Belandia, Iban, Cox, Ruud C., Dijkman, Ruud, Egmond, Maarten R., Verheiji, Hubertus M., Dekker, Niek
Publikováno v:
European Journal of Biochemistry. Mar99 Part 2, Vol. 260 Issue 3, p794. 7p. 2 Diagrams, 6 Graphs.
Publikováno v:
European Journal of Biochemistry. 8/1/95, Vol. 231 Issue 3, p747-753. 7p.