Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ruud A. Woutersen"'
Autor:
Niek C.A. van de Pas, Ruud A. Woutersen, Ben van Ommen, Ivonne M. C.M. Rietjens, Albert A. de Graaf
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 12, Pp 2734-2746 (2012)
Increased plasma cholesterol concentration is associated with increased risk of cardiovascular disease. This study describes the development, validation, and analysis of a physiologically based kinetic (PBK) model for the prediction of plasma cholest
Externí odkaz:
https://doaj.org/article/5e3b4e649fce40f49e39842bddce5d48
Publikováno v:
Carcinogenicity ISBN: 9781003067641
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8cef3854d112232c124906266a434dc
https://doi.org/10.1201/9781003067641-31
https://doi.org/10.1201/9781003067641-31
Autor:
Ruud A. Woutersen, Frédéric Schorsch, Marco Corvaro, Robin Gommans, Phil Botham, Gerrit Wolterink, Jan Willem van der Laan, Raffaella Corvi, Irene Manou, Federica Madia, Harm J. Heusinkveld, Jyotigna Mehta, Mirjam Luijten, Dick Lewis, Hedwig M. Braakhuis
Chemical substances are subjected to assessment of genotoxic and carcinogenic effects before being marketed to protect man and the environment from health risks. For agrochemicals, the long-term rodent carcinogenicity study is currently required from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b440c09a4b5cd12a6f885f03ceb039c
http://hdl.handle.net/10029/624557
http://hdl.handle.net/10029/624557
Autor:
Jyotigna Mehta, Harm J. Heusinkveld, E. Pasquier, Stephanie Melching-Kollmuss, Frédéric Schorsch, Ruud A. Woutersen, Mirjam Luijten, Raffaella Corvi, Marco Corvaro, Irene Manou, P. Marx-Stölting, F. Madia, J. Nygren, G. Wolterink, J.W. Vinken, G. Steiblen, Dick Lewis, Hedwig M. Braakhuis
Publikováno v:
Toxicology Letters. 350:S41
Autor:
Laura H.J. de Haan, Bert Spenkelink, Ans Punt, Ruud A. Woutersen, Marije Strikwold, Ivonne M.C.M. Rietjens
Publikováno v:
Archives of Toxicology, 91(5), 2119-2133
Archives of Toxicology
Archives of Toxicology 91 (2017) 5
Archives of Toxicology
Archives of Toxicology 91 (2017) 5
Toxicity outcomes derived in vitro do not always reflect in vivo toxicity values, which was previously observed for a series of phenols tested in the embryonic stem cell test (EST). Translation of in vitro data to the in vivo situation is therefore a
Autor:
Zvonimir Zvonar, Susan P. Felter, Federica Madia, Katrin Schutte, Ruud A. Woutersen, Abigail Jacobs, Hedwig M. Braakhuis, Jan Willem van der Laan, Gerrit Wolterink, Marco Corvaro, Stephanie Melching-Kollmuss, Irene Manou, Douglas C. Wolf, Franz Lamplmair, Jyotigna Mehta, Raffaella Corvi, Mirjam Luijten, Thomas Holmes, Dick Lewis, Miriam N. Jacobs, Nathalie Delrue, Harm J. Heusinkveld, Bodo Haas, Nicola J. Hewitt, Gina M. Hilton, Frédéric Schorsch, Christian Strupp, Fiona Sewell
Publikováno v:
Regulatory Toxicology and Pharmacology. 118:104789
Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies. However, these involve the use of large numbers of animals and the relevance of their predictive
Publikováno v:
Regulatory Toxicology and Pharmacology, 85, 132-149
Regulatory Toxicology and Pharmacology 85 (2017)
Regul Toxicol Pharmacol
Regulatory Toxicology and Pharmacology 85 (2017)
Regul Toxicol Pharmacol
In 1944, Draize et al., published a paper entitled “Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes”. The Organization for Economic Co-operation and Development published their fir
Autor:
Maged Younes, Matthew C. Wright, Ana Maria Rincon, Ine Waalkens Berendsen, Dario Battacchi, Ivan Stankovic, Ruud A. Woutersen
Publikováno v:
Toxicology Letters
s of the 52nd Congress of the European Societies of Toxicology (EUROTOX) Fibes Congress Center Seville, Spain, 04th-07th September 2016
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466dbf5e535abfd797d6cff36fff4b5e
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2652
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2652
Publikováno v:
Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1811(5), 333-342
Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 5, 1811, 333-342
Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids 1811 (2011) 5
Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 5, 1811, 333-342
Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids 1811 (2011) 5
The LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C) concentrations are determined by the activity of a complex network of reactions in several organs. Physiologically-based kinetic (PBK) computational models can be used to describe these differen
Autor:
Ivonne M.C.M. Rietjens, Bas J. Blaauboer, Aldert H. Piersma, Esther de Jong, Jochem Louisse, Johannes J.M. van de Sandt, Miriam Verwei, Ruud A. Woutersen
Publikováno v:
Toxicological sciences, 110(1), 117-124
Toxicological sciences 110 (2009) 1
Toxicological sciences 110 (2009) 1
The embryonic stem cell test (EST) has been proposed as an in vitro assay that might reduce animal experimentation in regulatory developmental toxicology. So far, evaluation of the EST was not performed using compounds within distinct chemical classe