Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Ruud A. Bank"'
Autor:
Nataly Puerta Cavanzo, Sophie A. Riesmeijer, Iris L. Holt-Kedde, Paul M. N. Werker, Bram Piersma, Peter Olinga, Ruud A. Bank
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Dupuytren’s disease is a chronic, progressive fibroproliferative condition of the hand fascia which results in digital contraction. So far, treatments do not directly interfere with the (myo)fibroblasts that are responsible for the formati
Externí odkaz:
https://doaj.org/article/686b76e24d904eaaaf0d16754775ab61
Autor:
Daan C.J. Mohede, MD, Igle Jan de Jong, MD, PhD, Ruud A. Bank, PhD, Mels F. van Driel, MD, PhD
Publikováno v:
Sexual Medicine, Vol 6, Iss 4, Pp 302-308 (2018)
Introduction: In Europe and the United States, verteporfin (Visudyne; VP) is registered and used in treating macular degeneration. Research showed that VP decreased expression of fibrotic genes in fibroblasts collected from nodules of patients suffer
Externí odkaz:
https://doaj.org/article/94d2a623b3444fc984ac58b7a587cf73
Publikováno v:
Frontiers in Medicine, Vol 7 (2021)
An unsolved therapeutic problem in fibrosis is the overproduction of collagen. In order to screen the effect of anti-fibrotic drugs on collagen deposition, the Scar-in-a-Jar approach has been introduced about a decade ago. With macromolecular crowdin
Externí odkaz:
https://doaj.org/article/b26db37c766342768d57a216cf62e413
Autor:
Wouter Tobias van Haaften, Tjasso Blokzijl, Hendrik Sijbrand Hofker, Peter Olinga, Gerard Dijkstra, Ruud A. Bank, Miriam Boersema
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 13 (2020)
Background and Aims: Crohn’s disease (CD) can be complicated by intestinal fibrosis. Pharmacological therapies against intestinal fibrosis are not available. The aim of this study was to determine whether pathways involved in collagen metabolism ar
Externí odkaz:
https://doaj.org/article/9e48b0b11a31439f91188307e7e9da02
Autor:
Emilia Bigaeva, Nataly Puerta Cavanzo, Elisabeth G. D. Stribos, Amos J. de Jong, Carin Biel, Henricus A. M. Mutsaers, Michael S. Jensen, Rikke Nørregaard, Anna M. Leliveld, Igle J. de Jong, Jan-Luuk Hillebrands, Harry van Goor, Miriam Boersema, Ruud A. Bank, Peter Olinga
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 459 (2020)
Animal models are a valuable tool in preclinical research. However, limited predictivity of human biological responses in the conventional models has stimulated the search for reliable preclinical tools that show translational robustness. Here, we us
Externí odkaz:
https://doaj.org/article/88f984b7474147c889380ff361af2440
Publikováno v:
Frontiers in Medicine, Vol 2 (2015)
Chronic organ injury leads to fibrosis and eventually organ failure. Fibrosis is characterized by excessive synthesis, remodeling and contraction of extracellular matrix produced by myofibroblasts. Myofibroblasts are the key cells in the pathophysiol
Externí odkaz:
https://doaj.org/article/aea9962d24c946b5b9c801eb48e687e9
Autor:
Ruud A. Bank, Bram Piersma
Publikováno v:
Essays in Biochemistry. 63:377-387
The hallmark of fibrosis is an excessive accumulation of collagen, ultimately leading to organ failure. It has become evident that the deposited collagen also exhibits qualitative modifications. A marked modification is the increased cross-linking, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ad98b5338c982082206bb4b7f8ddf1
https://doi.org/10.1042/ebc20180051
https://doi.org/10.1042/ebc20180051
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91559 (2014)
One of the most potent pro-fibrotic cytokines is transforming growth factor (TGFβ). TGFβ is involved in the activation of fibroblasts into myofibroblasts, resulting in the hallmark of fibrosis: the pathological accumulation of collagen. Interleukin
Externí odkaz:
https://doaj.org/article/3ca31ec8dbde46e9af039fd22d52988b
Publikováno v:
Sexual Medicine, Vol 6, Iss 4, Pp 302-308 (2018)
Sexual Medicine
Sexual medicine, 6(4), 302-308. ELSEVIER SCI LTD
Sexual Medicine
Sexual medicine, 6(4), 302-308. ELSEVIER SCI LTD
Introduction In Europe and the United States, verteporfin (Visudyne; VP) is registered and used in treating macular degeneration. Research showed that VP decreased expression of fibrotic genes in fibroblasts collected from nodules of patients sufferi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69549f5ec046729053258274821b4411
https://doi.org/10.1016/j.esxm.2018.08.002
https://doi.org/10.1016/j.esxm.2018.08.002
Autor:
Svenja Sydor, Ruud A. Bank, Natalia Smith-Cortinez, Janette Heegsma, Dirk R. de Waart, Defu Kong, Klaas Nico Faber, Raphael R. Fagundes, Coen C. Paulusma, Vincent E de Meijer, Peter Olinga, Cormac T. Taylor, Valentina Gomez
Publikováno v:
FASEB journal, 35(2):e21219. FASEB
The FASEB Journal, 35(2):e21219. FEDERATION AMER SOC EXP BIOL
The FASEB Journal, 35(2):e21219. FEDERATION AMER SOC EXP BIOL
Liver fibrosis is characterized by the accumulation of extracellular matrix proteins, mainly composed of collagen. Hepatic stellate cells (HSCs) mediate liver fibrosis by secreting collagen. Vitamin C (ascorbic acid) is a cofactor of prolyl-hydroxyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798f8808711f3673ea9f7dfe25e61517
http://www.scopus.com/inward/record.url?scp=85096751472&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85096751472&partnerID=8YFLogxK