Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rutwij A. Dave"'
Autor:
Yan Wu, Jean-Michel Vernes, Wei-Ching Liang, Karla Lancaster, Melissa Schutten, Y. Gloria Meng, Gopinath S. Palanisamy, Rutwij A. Dave, Matthew S Holdren, Adeyemi O Adedeji, Fiona Zhong, Mayur S. Mitra, Shannon J. Turley
Publikováno v:
Toxicological Sciences. 175:24-34
Transforming growth factor β (TGFβ) signaling has been recently shown to reduce antitumor response to PD-L1 blockade, leading to a renewed enthusiasm in developing anti-TGFβ therapies for potential combination with cancer immunotherapy agents. Inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93edf8656b6bd4003a8a622169a138a7
https://doi.org/10.1093/toxsci/kfaa024
https://doi.org/10.1093/toxsci/kfaa024
Publikováno v:
Biopharmaceutics & Drug Disposition. 39:218-231
Renal impairment (RI) significantly impacts the clearance of drugs through changes in the glomerular filtration rate, protein binding and alterations in the expression of renal drug transport proteins and hepatic metabolizing enzymes. The objectives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d047b4abfce0280937c6061de84776d
https://doi.org/10.1002/bdd.2128
https://doi.org/10.1002/bdd.2128
Publikováno v:
The AAPS Journal. 19:1449-1460
An overdose of γ-hydroxybutyric acid (GHB), a drug of abuse, results in fatality caused by severe respiratory depression. In this study, a semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model was developed to characterize monocarboxylate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70854912b6d5b8b13c09222a5301a24
https://doi.org/10.1208/s12248-017-0111-7
https://doi.org/10.1208/s12248-017-0111-7
Autor:
Rutwij A. Dave, Marilyn E. Morris
Publikováno v:
Biopharmaceutics & Drug Disposition. 37:287-309
In this study, a quantitative threshold was determined for the high/low extent of urinary excretion (UE) of compounds in humans, using a straightforward but robust statistical method known as receiver operating characteristic curve (ROC) analysis, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4e398194474c4772d4c94ddc590fbfb
https://doi.org/10.1002/bdd.2013
https://doi.org/10.1002/bdd.2013
Publikováno v:
Encyclopedia of Signaling Molecules ISBN: 9781461464389
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7aa3465d1325e26c9f5449f555ed79b
https://doi.org/10.1007/978-1-4614-6438-9_101724-1
https://doi.org/10.1007/978-1-4614-6438-9_101724-1
Autor:
Rutwij A. Dave, Marilyn E. Morris
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics. 42(5)
This study developed a semi-mechanistic kidney model incorporating physiologically-relevant fluid reabsorption and transporter-mediated active reabsorption. The model was applied to data for the drug of abuse γ-hydroxybutyric acid (GHB), which exhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68fe1507bf4c02bbacd864fec17aa29
https://pubmed.ncbi.nlm.nih.gov/26341876
https://pubmed.ncbi.nlm.nih.gov/26341876
Quantitative Structure-Pharmacokinetic Relationships for the Prediction of Renal Clearance in Humans
Autor:
Rutwij A. Dave, Marilyn E. Morris
Renal clearance (CLR), a major route of elimination for many drugs and drug metabolites, represents the net result of glomerular filtration, active secretion and reabsorption, and passive reabsorption. The aim of this study was to develop quantitativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128df3a95b29c7b84293b0cd2f8a4ed5
https://europepmc.org/articles/PMC4279087/
https://europepmc.org/articles/PMC4279087/
Autor:
Rutwij A. Dave, Marilyn E. Morris
Phenethyl isothiocyanate (PEITC)—a naturally occurring isothiocyanate in cruciferous vegetables—has been extensively studied as a chemopreventive agent in several preclinical species and in humans. Pharmacokinetic features of unchanged PEITC are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cbc0eff1d2919dd7a65f13a7bea7c8
https://europepmc.org/articles/PMC4070252/
https://europepmc.org/articles/PMC4070252/
The objective of the present study was to evaluate mechanistic pharmacokinetic models describing active renal secretion and reabsorption over a range of Michaelis-Menten parameter estimates and doses. Plasma concentration and urinary excretion profil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5822f4da590c26084aba6f85869879a5
https://europepmc.org/articles/PMC3535105/
https://europepmc.org/articles/PMC3535105/