Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

Autor: Reddy Peera Kommaddi, Aditi Verma, Graciela Muniz-Terrera, Vivek Tiwari, Keerthana Chithanathan, Latha Diwakar, Ruturaj Gowaikar, Smitha Karunakaran, Palash Kumar Malo, Neill R. Graff-Radford, Gregory S. Day, Christoph Laske, Jonathan Vöglein, Georg Nübling, Takeshi Ikeuchi, Kensaku Kasuga, the Dominantly Inherited Alzheimer Network (DIAN), Vijayalakshmi Ravindranath

Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Women carry a higher burden of Alzheimer’s disease (AD) compared to men, which is not accounted entirely by differences in lifespan. To identify the mechanisms underlying this effect, we investigated sex-specific differences in the progres

Externí odkaz: https://doaj.org/article/2bfd52fdcfe340b289a3a6a570cfb8d0

Endothelin-1 mediated vasoconstriction leads to memory impairment and synaptic dysfunction

Autor: Keerthana Chithanathan, Deepika Singh Tomar, Latha Diwakar, Barathan Gnanabharathi, Ruturaj Gowaikar, Vijayalakshmi Ravindranath

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Cerebrovascular lesions seen as white matter hyperintensity in MRI of elderly population caused due to micro-infracts and micro-bleeds contributes to vascular dementia. Such vascular insult caused by impairment in blood flow to specific area in brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3146d9a542b977e6166162b886dae3
http://europepmc.org/articles/PMC7921549

Single bilateral injection of endothelin‐1 leads to temporary deficits in memory and synaptic dysfunction

Autor: Ruturaj Gowaikar, Keerthana Chithanathan, Latha Diwakar, Vijayalakshmi Ravindranath, Deepika Singh Tomar

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e855a84c61bf3aad5fefb7fc22a8fd62
https://doi.org/10.1002/alz.042720

ET-1 mediated vasoconstriction leads to memory impairment and synaptic dysfunction reminiscent of Alzheimer’s disease phenotype

Autor: Latha Diwakar, Ruturaj Gowaikar, Keerthana Chithanathan, null Gnanabharathi, Deepika Singh Tomar, Vijayalakshmi Ravindranath

Background Cerebrovascular lesions seen as white matter hyperintensity in MRI of elderly population provides evidence for micro-infracts and micro-bleeds, which contribute to vascular dementia. Such vascular insult may be caused by impairment in bloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f92b4357c5b29f434bf489a4eacfb69
https://doi.org/10.21203/rs.3.rs-25345/v1

Synapse loss and progress of Alzheimer’s disease -A network model

Autor: Govindan Rangarajan, R. E. Amritkar, G. Kashyap, Vijayalakshmi Ravindranath, G. Ambika, Debasish Das, Deepti Bapat, Ruturaj Gowaikar

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.6555. ⟨10.1038/s41598-019-43076-y⟩

We present observational evidence from studies on primary cortical cultures from AD transgenic mice, APPSwe/PS1ΔE9 (APP/PS1) mice, for significant decrease in total spine density at DIV-15 and onward. This indicates reduction in potential healthy sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0890594c8acf004618a673a8819e05c9
https://doi.org/10.1038/s41598-019-43076-y