Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Characterization of apo-form selective inhibition of indoleamine 2,3-dioxygenase

Autor: Martha Alicia De La Rosa, Kurt Weaver, Lisa M. Shewchuk, Rachel D. Totoritis, John Seal, David Favre, Guofeng Zhang, Makda Mebrahtu, Tia Lewis, Marcel Muelbaier, Richard M. Dunham, Giovanna Bergamini, Jeffrey Guss, Alan R. Rendina, Nino Campobasso, Wieslaw M. Kazmierski, Douglas W. Thomson, Robert Midgett, Katrin Strohmer, Anna Rutkowska-Klute, Rosalie Matico, Thomas Consler, Cunyu Zhang, David Taylor, Sabrina Bédard, Rodrigo F Ortiz-Meoz, Liping Wang

Indoleamine-2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that catalyzes the rate-limiting step in the kynurenine pathway of tryptophan (TRP) metabolism. As an inflammation-induced immunoregulatory enzyme, pharmacological inhibition of IDO1 ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6eedaf9b8c5819ab8c1e04bab343a2
https://doi.org/10.1101/324947

Abstract 2919: Discovery of small-molecule compounds targeting c-MYC using a novel cell-based screen

Autor: Stuart Paul Romeril, Gopinath Ganji, Dirk A. Heerding, George P. Livi, Anna Rutkowska-Klute, William Hoi Hong Li, James F. Mack, Elisabeth A. Minthorn, Derrick W. Meinhold, Carolyn A. Buser, Jesus R. Medina, Lorena A. Kallal, Shanker K. Sundaram, Biju Mangatt, Anthony Della Pietra, Sonja Ghidelli-Disse, Anna Waszkiewicz, Jon-Paul Jaworski, Thomas J. Berrodin, Rakesh Kumar, Wendy S. Halsey, Christian S. Sherk, Gerard Drewes

Publikováno v: Cancer Research. 78:2919-2919

Elevated expression of the c-MYC oncogene (either due to gene amplification, translocation, abnormality in upstream signaling pathways and/or protein stabilization) is one of the most common abnormalities in human cancers. Efforts to identify direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64bc4d93904423361b095d651579562d
https://doi.org/10.1158/1538-7445.am2018-2919

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

Autor: Williams, Tobias D.^1,2,3 (AUTHOR), Michalak, Ewa M.^1,2,3 (AUTHOR), Carey, Kirstyn.T.^2,3 (AUTHOR), Lam, Enid Y.N.^2,3 (AUTHOR), Anderson, Ashley^2,3 (AUTHOR), Griesbach, Esther¹ (AUTHOR), Chan, Yih-Chih^2,3 (AUTHOR), Papasaikas, Panagiotis¹ (AUTHOR), Tan, Vicky W.T.^2,3 (AUTHOR), Ngo, Linh^2,3 (AUTHOR), MacPherson, Laura^2,3 (AUTHOR), Gilan, Omer^2,3 (AUTHOR), Rucinski, Amber^2,3 (AUTHOR), Rutkowska-Klute, Anna⁴ (AUTHOR), Zinn, Nico⁴ (AUTHOR), Grandi, Paola⁴ (AUTHOR), Bantscheff, Marcus⁴ (AUTHOR), Prinjha, Rab K.⁵ (AUTHOR), Dawson, Sarah-Jane^2,3,6 (AUTHOR), Chao, Jeffrey A.¹ (AUTHOR) jeffrey.chao@fmi.ch

Publikováno v: Molecular Cell. Jan2025, Vol. 85 Issue 1, p117-113. 1p.