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Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants.

Autor: Smith BD; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Kaufman MD; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Lu WP; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Gupta A; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Leary CB; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Wise SC; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Rutkoski TJ; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Ahn YM; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Al-Ani G; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Bulfer SL; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Caldwell TM; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Chun L; Emerald Biostructures, Bainbridge Island, WA 98110, USA., Ensinger CL; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Hood MM; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., McKinley A; Portland VA Medical Center and Oregon Health & Science University Knight Cancer Institute, Portland, OR 97239, USA., Patt WC; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Ruiz-Soto R; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Su Y; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Telikepalli H; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Town A; Portland VA Medical Center and Oregon Health & Science University Knight Cancer Institute, Portland, OR 97239, USA., Turner BA; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Vogeti L; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Vogeti S; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Yates K; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Janku F; The University of Texas MD Anderson Cancer Center, Department of Investigational Cancer Therapeutics, Houston, TX 77030, USA., Abdul Razak AR; Princess Margaret Cancer Centre, Cancer Clinical Research Unit, Toronto, ON, Canada., Rosen O; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA., Heinrich MC; Portland VA Medical Center and Oregon Health & Science University Knight Cancer Institute, Portland, OR 97239, USA., Flynn DL; Deciphera Pharmaceuticals, Inc., Waltham, MA 02451, USA. Electronic address: dflynn@deciphera.com.

Publikováno v: Cancer cell [Cancer Cell] 2019 May 13; Vol. 35 (5), pp. 738-751.e9.

Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.

Autor: Peng SB; Eli Lilly and Company, Indianapolis, IN 46285, USA. Electronic address: peng_sheng-bin@lilly.com., Henry JR; Eli Lilly and Company, Indianapolis, IN 46285, USA., Kaufman MD; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA., Lu WP; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA., Smith BD; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA., Vogeti S; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA., Rutkoski TJ; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA., Wise S; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA., Chun L; Emerald Biostructures, Bainbridge Island, WA 98110, USA., Zhang Y; Eli Lilly and Company, Indianapolis, IN 46285, USA., Van Horn RD; Eli Lilly and Company, Indianapolis, IN 46285, USA., Yin T; Eli Lilly and Company, Indianapolis, IN 46285, USA., Zhang X; Eli Lilly and Company, Indianapolis, IN 46285, USA., Yadav V; Eli Lilly and Company, Indianapolis, IN 46285, USA., Chen SH; Eli Lilly and Company, Indianapolis, IN 46285, USA., Gong X; Eli Lilly and Company, Indianapolis, IN 46285, USA., Ma X; Eli Lilly and Company, Indianapolis, IN 46285, USA., Webster Y; Eli Lilly and Company, Indianapolis, IN 46285, USA., Buchanan S; Eli Lilly and Company, Indianapolis, IN 46285, USA., Mochalkin I; Eli Lilly and Company, Indianapolis, IN 46285, USA., Huber L; Eli Lilly and Company, Indianapolis, IN 46285, USA., Kays L; Eli Lilly and Company, Indianapolis, IN 46285, USA., Donoho GP; Eli Lilly and Company, Indianapolis, IN 46285, USA., Walgren J; Eli Lilly and Company, Indianapolis, IN 46285, USA., McCann D; Eli Lilly and Company, Indianapolis, IN 46285, USA., Patel P; Eli Lilly and Company, Indianapolis, IN 46285, USA., Conti I; Eli Lilly and Company, Indianapolis, IN 46285, USA., Plowman GD; Eli Lilly and Company, Indianapolis, IN 46285, USA., Starling JJ; Eli Lilly and Company, Indianapolis, IN 46285, USA., Flynn DL; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA.

Publikováno v: Cancer cell [Cancer Cell] 2015 Sep 14; Vol. 28 (3), pp. 384-98. Date of Electronic Publication: 2015 Sep 03.

Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.

Autor: Henry JR; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Kaufman MD; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Peng SB; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Ahn YM; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Caldwell TM; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Vogeti L; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Telikepalli H; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Lu WP; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Hood MM; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Rutkoski TJ; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Smith BD; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Vogeti S; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Miller D; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Wise SC; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States., Chun L; §Emerald Biostructures, Bainbridge Island, Washington 98110, United States., Zhang X; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Zhang Y; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Kays L; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Hipskind PA; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Wrobleski AD; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Lobb KL; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Clay JM; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Cohen JD; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Walgren JL; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., McCann D; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Patel P; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Clawson DK; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Guo S; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Manglicmot D; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Groshong C; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Logan C; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Starling JJ; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Flynn DL; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 May 28; Vol. 58 (10), pp. 4165-79. Date of Electronic Publication: 2015 May 12.

Structure, dynamics, and specificity of endoglucanase D from Clostridium cellulovorans.

Autor: Bianchetti CM; Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA; Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, WI 53706, USA., Brumm P, Smith RW, Dyer K, Hura GL, Rutkoski TJ, Phillips GN Jr

Publikováno v: Journal of molecular biology [J Mol Biol] 2013 Nov 15; Vol. 425 (22), pp. 4267-85. Date of Electronic Publication: 2013 Jun 08.