Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy.

Autor: Engelke UF; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., van Outersterp RE; Institute for Molecules and Materials, FELIX Laboratory and., Merx J; Institute for Molecules and Materials, Synthetic Organic Chemistry, Radboud University, Nijmegen, Netherlands., van Geenen FA; Institute for Molecules and Materials, FELIX Laboratory and., van Rooij A; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Berden G; Institute for Molecules and Materials, FELIX Laboratory and., Huigen MC; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Kluijtmans LA; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Peters TM; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands., Al-Shekaili HH; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia Vancouver, British Columbia, Canada., Leavitt BR; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia Vancouver, British Columbia, Canada., de Vrieze E; Department of Otorhinolaryngology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands., Broekman S; Department of Otorhinolaryngology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands., van Wijk E; Department of Otorhinolaryngology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands., Tseng LA; Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, Netherlands., Kulkarni P; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Rutjes FP; Institute for Molecules and Materials, Synthetic Organic Chemistry, Radboud University, Nijmegen, Netherlands., Mecinović J; Institute for Molecules and Materials, Synthetic Organic Chemistry, Radboud University, Nijmegen, Netherlands.; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark., Struys EA; Department of Clinical Chemistry, Amsterdam University Medical Centers, location VU Medical Centre, Amsterdam, Netherlands., Jansen LA; Division of Pediatric Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Gospe SM Jr; Departments of Neurology and Pediatrics, University of Washington, Seattle, Washington, USA.; Department of Pediatrics, Duke University, Durham, North Carolina, USA., Mercimek-Andrews S; Division of Clinical and Metabolic Genetics, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada., Hyland K; Medical Neurogenetics Laboratories, Atlanta, Georgia, USA., Willemsen MA; Department of Pediatric Neurology, Radboud University Medical Centre, Nijmegen, Netherlands., Bok LA; Department of Pediatrics, Máxima Medical Centre, Veldhoven, Netherlands., van Karnebeek CD; Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, Netherlands.; Department of Pediatrics-Metabolic Diseases, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, Netherlands.; United for Metabolic Diseases (UMD), Netherlands., Wevers RA; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Boltje TJ; Institute for Molecules and Materials, Synthetic Organic Chemistry, Radboud University, Nijmegen, Netherlands., Oomens J; Institute for Molecules and Materials, FELIX Laboratory and.; Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, Netherlands., Martens J; Institute for Molecules and Materials, FELIX Laboratory and., Coene KL; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2021 Aug 02; Vol. 131 (15).

Pharmacological Inhibition of Vanin Activity Attenuates Transplant Vasculopathy in Rat Aortic Allografts.

Autor: Wedel J; 1 Pathology Section, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.2 Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.3 Chiralix B.V., Nijmegen, The Netherlands.4 Institute for Molecules and Materials, Radboud University Nijmegen, Nijmegen, The Netherlands., Jansen PA, Botman PN, Rutjes FP, Schalkwijk J, Hillebrands JL

Publikováno v: Transplantation [Transplantation] 2016 Aug; Vol. 100 (8), pp. 1656-66.

NMR detection in biofluid extracts at sub-μM concentrations via para-H2 induced hyperpolarization.

Autor: Reile I; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. m.tessari@science.ru.nl., Eshuis N; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. m.tessari@science.ru.nl., Hermkens NK; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. m.tessari@science.ru.nl., van Weerdenburg BJ; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. m.tessari@science.ru.nl., Feiters MC; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. m.tessari@science.ru.nl., Rutjes FP; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. m.tessari@science.ru.nl., Tessari M; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. m.tessari@science.ru.nl.

Publikováno v: The Analyst [Analyst] 2016 Jun 20; Vol. 141 (13), pp. 4001-5.

NMR-Based Chemosensing via p-H2 Hyperpolarization: Application to Natural Extracts.

Autor: Hermkens NK; Institute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Eshuis N; Institute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., van Weerdenburg BJ; Institute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Feiters MC; Institute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Rutjes FP; Institute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Wijmenga SS; Institute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Tessari M; Institute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.

Publikováno v: Analytical chemistry [Anal Chem] 2016 Mar 15; Vol. 88 (6), pp. 3406-12. Date of Electronic Publication: 2016 Mar 03.

2D NMR Trace Analysis by Continuous Hyperpolarization at High Magnetic Field.

Autor: Eshuis N; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525 AJ (Netherlands)., Aspers RL; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525 AJ (Netherlands)., van Weerdenburg BJ; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525 AJ (Netherlands)., Feiters MC; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525 AJ (Netherlands)., Rutjes FP; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525 AJ (Netherlands)., Wijmenga SS; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525 AJ (Netherlands)., Tessari M; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525 AJ (Netherlands). m.tessari@science.ru.nl.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2015 Nov 23; Vol. 54 (48), pp. 14527-30. Date of Electronic Publication: 2015 Oct 06.