Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ruthrothaselvi Bharathavikru"'
Publikováno v:
Genes & Development. 32:993-995
Overgrowth syndromes such as Perlman syndrome and associated pediatric cancers, including Wilms tumor, arise through genetic and, in certain instances, also epigenetic changes. In the case of the Beckwith-Wiedemann overgrowth syndrome and in Wilms tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aae329231b7fd17a638bda1653169afd
https://doi.org/10.1101/gad.317792.118
https://doi.org/10.1101/gad.317792.118
Autor:
Stuart Aitken, Viktoriya Stancheva, Jocelyn Charlton, Nicholas D. Hastie, Ruthrothaselvi Bharathavikru, Joan Slight, Giulia Petrovich, Kathy Pritchard-Jones, Abdelkader Essafi
Wilms’ tumour 1 (WT1) is a transcription factor and a tumour suppressor, essential for the development and homeostasis of multiple tissues derived from the intermediate and lateral plate mesoderm. Germline WT1 mutations result in the eponymous paed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d4169bdec49dea9fc4c1b654be537c
Publikováno v:
Genesdevelopment. 32(15-16)
In this study, Chen et al. provide novel insight into Wilms tumor by investigating the mechanisms by which mutations in the microRNA biogenesis machinery drive tumorigenesis. They show that the transcription factor PLAG1 is a microRNA target gene tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::19f02183d524b09dcb24cbd83b800763
https://pubmed.ncbi.nlm.nih.gov/30026293
https://pubmed.ncbi.nlm.nih.gov/30026293
Autor:
Ruthrothaselvi, Bharathavikru, Tatiana, Dudnakova, Stuart, Aitken, Joan, Slight, Mara, Artibani, Peter, Hohenstein, David, Tollervey, Nick, Hastie
Publikováno v:
Genesdevelopment. 31(4)
Wilms' tumor 1 (WT1) is essential for the development and homeostasis of multiple mesodermal tissues. Despite evidence for post-transcriptional roles, no endogenous WT1 target RNAs exist. Using RNA immunoprecipitation and UV cross-linking, we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe20695f4be63f11f24f53407e1c9fb3
https://pubmed.ncbi.nlm.nih.gov/28289143
https://pubmed.ncbi.nlm.nih.gov/28289143
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1467
Tumor-suppressor protein Wt1 has been shown to interact with specific proteins that influence its function. These protein interactions have been identified as direct individual interactions but with the potential to exist as a part of a multiprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07633363f0eb3b9f989552fd7d8fb604
https://pubmed.ncbi.nlm.nih.gov/27417970
https://pubmed.ncbi.nlm.nih.gov/27417970
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1467
Tumor suppressor protein, Wt1 is a transcription factor that binds to DNA sequence similar to the Early Growth Response gene, EGR1 consensus binding sequence. Biophysical and biochemical validations have shown that the zinc fingers of Wt1 are capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a25619aa01fc2b8f6e36c89981fe99f4
https://pubmed.ncbi.nlm.nih.gov/27417971
https://pubmed.ncbi.nlm.nih.gov/27417971
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1467
Differential gene expression analysis has been conventionally performed by microarray techniques; however with the recent advent of next-generation sequencing (NGS) approaches, it has become easier to analyze the coding as well as the noncoding compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d737ace6857f93073470e01c8620edce
https://pubmed.ncbi.nlm.nih.gov/27417972
https://pubmed.ncbi.nlm.nih.gov/27417972
Publikováno v:
The Wilms' Tumor (WT1) Gene ISBN: 9781493940219
Differential gene expression analysis has been conventionally performed by microarray techniques; however with the recent advent of next-generation sequencing (NGS) approaches, it has become easier to analyze the coding as well as the noncoding compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6a7f78e81b7e6e7af2b5da23b99387e
https://doi.org/10.1007/978-1-4939-4023-3_18
https://doi.org/10.1007/978-1-4939-4023-3_18
Publikováno v:
The Wilms' Tumor (WT1) Gene ISBN: 9781493940219
Tumor suppressor protein, Wt1 is a transcription factor that binds to DNA sequence similar to the Early Growth Response gene, EGR1 consensus binding sequence. Biophysical and biochemical validations have shown that the zinc fingers of Wt1 are capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f333bbe603f4fddfea1c743ce822066
https://doi.org/10.1007/978-1-4939-4023-3_17
https://doi.org/10.1007/978-1-4939-4023-3_17
Publikováno v:
The Wilms' Tumor (WT1) Gene ISBN: 9781493940219
Tumor-suppressor protein Wt1 has been shown to interact with specific proteins that influence its function. These protein interactions have been identified as direct individual interactions but with the potential to exist as a part of a multiprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6082b046f8a927ef0fddaf08751f232
https://doi.org/10.1007/978-1-4939-4023-3_16
https://doi.org/10.1007/978-1-4939-4023-3_16