A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors

Autor: Jessica Hartmann, Robert C. Münch, Ruth-Therese Freiling, Irene C. Schneider, Birgit Dreier, Washington Samukang, Joachim Koch, Markus A. Seeger, Andreas Plückthun, Christian J. Buchholz

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 728- (2021)

Externí odkaz: https://doaj.org/article/d702c76d5cbf4af7918cdd04acdd81fa

A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors

Autor: Joachim Koch, Robert C. Münch, Christian J. Buchholz, Washington T. Samukange, Ruth-Therese Freiling, Birgit Dreier, Irene C. Schneider, Andreas Plückthun, Jessica Hartmann, Markus A. Seeger

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 728-(2021)
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss, Pp 128-143 (2018)

Delivering genes selectively to the therapeutically relevant cell type is among the prime goals of vector development. Here, we present a high-throughput selection and screening process that identifies designed ankyrin repeat proteins (DARPins) optim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e309e958ede0cfff158801a7722705
https://doi.org/10.1016/j.omtm.2018.07.001