Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation

Autor: Jingang Gui, Ian Dransfield, Jürgen Schwarze, Rodger Duffin, Adriano G. Rossi, Philippe M D Potey, Christopher Haslett, Jennifer M Felton, David A. Dorward, Ruth W. Craig, Christopher D. Lucas, Calum T. Robb, Jennifer A Cartwright

Publikováno v: Felton, J M, Dorward, D A, Cartwright, J, Potey, P M D, Robb, C T, Gui, J, Craig, R W, Schwarze, J, Haslett, C, Duffin, R, Dransfield, I, Lucas, C D & Rossi, A G 2020, ' Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation ', Thorax, vol. 75, no. 7, pp. 600-605 . https://doi.org/10.1136/thoraxjnl-2019-213204
Thorax

Eosinophils are key effector cells in allergic diseases. Here we investigated Mcl-1 (an anti-apoptotic protein) in experimental allergic airway inflammation using transgenic overexpressing human Mcl-1 mice (hMcl-1) and reducing Mcl-1 by a cyclin-depe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5590db05029951e9c4ed70b8e912cdc2
https://hdl.handle.net/20.500.11820/6740e9e8-1b83-4e77-ae17-b57217d8e829

Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages

Autor: Steven D. Shapiro, David H. Dockrell, Ruth W. Craig, Paul Collini, Mohammed Mohasin, Martin A. Bewley, Helen M. Marriott, Moira K. B. Whyte, David Singh, David R. Greaves, Julie Swales, Christopher E. Brightling, Peter J. Barnes, Louise E. Donnelly, Julie A. Preston, Richard C. Budd

Publikováno v: Bewley, M A, Preston, J A, Mohasin, M, Marriott, H M, Budd, R C, Swales, J, Collini, P, Greaves, D R, Craig, R W, Brightling, C E, Donnelly, L E, Barnes, P J, Singh, D, Shapiro, S D, Whyte, M & Dockrell, D H 2017, ' Impaired mitochondrial microbicidal responses in chronic obstructive pulmonary disease macrophages. ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.201608-1714OC
Bewley, M A, Preston, J A, Mohasin, M, Marriott, H M, Budd, R C, Swales, J, Collini, P, Greaves, D R, Craig, R W, Brightling, C E, Donnelly, L E, Barnes, P J, Singh, D, Shapiro, S D, Whyte, M K B & Dockrell, D H 2017, ' Impaired mitochondrial microbicidal responses in chronic obstructive pulmonary disease macrophages ', American Journal of Respiratory and Critical Care Medicine, vol. 196, no. 7, pp. 845–855 . https://doi.org/10.1164/rccm.201608-1714OC

Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by impaired clearance of pulmonary bacteria. Objectives: The effect of COPD on alveolar macrophage (AM) microbicidal responses was investigated. Methods: AMs were obtained from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca37696983422ddd3b3a071a6330e43
https://pubmed.ncbi.nlm.nih.gov/28637925

N-terminal Truncation of Antiapoptotic MCL1, but Not G2/M-induced Phosphorylation, Is Associated with Stabilization and Abundant Expression in Tumor Cells

Autor: Ruth W. Craig, Liping Qian, Steven J. Weintraub, Aaron M. Domina, Julie A. Vrana, Karen Braley, John M. Neveu, Christine K. Bieszczad, Ping Zhou, William S. Lane, Alfredo De Biasio

Publikováno v: Journal of Biological Chemistry. 282:23919-23936

The antiapoptotic BCL2 family member MCL1 is normally up- and down-modulated in response to environmental signals and conditions, but is constitutively expressed in cancer where it promotes cell survival and drug resistance. A post-translational modi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ccdf8f0dac9bcf3b9bff78541ddafc
https://doi.org/10.1074/jbc.m700938200

Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells

Autor: Roberto R. Rosato, Sonia C. Maggio, Peter Atadja, Ruth W. Craig, Paul Dent, Julie Vrana, Steven Grant, Jorge A. Almenara

Publikováno v: Molecular Cancer Therapeutics. 4:1772-1785

Interactions between the novel histone deacetylase inhibitor LAQ824 and the cyclin-dependent kinase inhibitor roscovitine were examined in human leukemia cells. Pretreatment (24 hours) with a subtoxic concentration of LAQ824 (30 nmol/L) followed by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052fcae0610e682cc515852a300b2e4d
https://doi.org/10.1158/1535-7163.mct-05-0157

MCL1 Enhances the Survival of CD8+ Memory T Cells after Viral Infection

Autor: Ching-Yi Tsai, Yan Song, Amanda J. Morales, Tian Ma, Edward J. Usherwood, Jingang Gui, Ruth W. Craig, Zhuting Hu, Ethan Dmitrovsky, Li-Hao Huang

Viral infection results in the generation of massive numbers of activated effector CD8 + T cells that recognize viral components. Most of these are short-lived effector T cells (SLECs) that die after clearance of the virus. However, a small proportio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ad5688dadcd43c6138bbeff7f6dbff
https://europepmc.org/articles/PMC4338882/