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Akademický článek

Early detection of ventilation-induced brain injury using magnetic resonance spectroscopy and diffusion tensor imaging: an in vivo study in preterm lambs.

Autor: Béatrice Skiöld, Qizhu Wu, Stuart B Hooper, Peter G Davis, Richard McIntyre, Mary Tolcos, James Pearson, Ruth Vreys, Gary F Egan, Samantha K Barton, Jeanie L Y Cheong, Graeme R Polglase

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95804 (2014)

BACKGROUND AND AIM: High tidal volume (VT) ventilation during resuscitation of preterm lambs results in brain injury evident histologically within hours after birth. We aimed to investigate whether magnetic resonance spectroscopy (MRS) and/or diffusi

Externí odkaz: https://doaj.org/article/3decbe40701b4ac9b78e393d7c4444e5

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Multimodal imaging of subventricular zone neural stem/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum

Autor: Annemie Van der Linden, Ruth Vreys, Marleen Verhoye, Janaki Raman Rangarajan, Caroline Guglielmetti, Jelle Praet, Nathalie De Vocht, Frederik Maes, Peter Ponsaerts

Publikováno v: NeuroImage; Vol 86
NeuroImage
Neuroimage

Multiple sclerosis is a devastating demyelinating disease of the central nervous system(CNS) in which endogenousremyelination, and thus recovery, often fails. Although the cuprizone mouse model allowed elucidation of many molecularfactors governing r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fad90cfdc7938c63a0dea7b1c733a17

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Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain

Autor: Frederik Maes, Greetje Vande Velde, Janaki Raman Rangarajan, Marleen Verhoye, Annemie Van der Linden, Tom Dresselaers, Veerle Baekelandt, Zeger Debyser, Caroline Guglielmetti, Uwe Himmelreich, Ruth Vreys

Publikováno v: NeuroImage; Vol 62
Neuroimage

Endogenous neural stem cells have the potential to facilitate therapy for various neurodegenerative brain disorders. To increase our understanding of neural stem and progenitor cell biology in healthy and diseased brain, methods to label and visualiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b25daa34f7a34eb243af1799f92df1

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Evaluation of the specificity and sensitivity of ferritin as an MRI reporter gene in the mouse brain using lentiviral and adeno-associated viral vectors

Autor: Veerle Baekelandt, A. Van der Linden, Jaan Toelen, Janaki Raman Rangarajan, Tom Dresselaers, Frederik Maes, Ruth Vreys, Zeger Debyser, Olga Krylychkina, Uwe Himmelreich, G. Vande Velde, Abdelilah Ibrahimi

Publikováno v: Gene Therapy; Vol 18
Gene therapy

The development of in vivo imaging protocols to reliably track transplanted cells or to report on gene expression is critical for treatment monitoring in (pre)clinical cell and gene therapy protocols. Therefore, we evaluated the potential of lentivir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb750753d481ded7c34e9ef387d06ec8
https://doi.org/10.1038/gt.2011.2

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Early detection of ventilation-induced brain injury using magnetic resonance spectroscopy and diffusion tensor imaging: an in vivo study in preterm lambs

Autor: Samantha K. Barton, Jeanie Ling Yoong Cheong, Graeme R. Polglase, Peter G Davis, Mary Tolcos, Richard McIntyre, Stuart B. Hooper, James T. Pearson, Beatrice Skiold, Ruth Vreys, Qi-Zhu Wu, Gary F. Egan

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95804 (2014)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182d7cb6f309a1663d9d3a015f7e6cde
http://europepmc.org/articles/PMC3997476?pdf=render

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In Vivo Monitoring of Adult Neurogenesis in Health and Disease

Autor: Ruth Vreys, Annemie Van der Linden, Ludwig Aigner, Sebastien Couillard-Despres

Publikováno v: Frontiers in Neuroscience, Vol 5 (2011)
Frontiers in Neuroscience
Frontiers in neuroscience

Adult neurogenesis, i.e. the generation of new neurons in the adult brain, presents an enormous potential for regenerative therapies of the central nervous system (CNS). While 5-bromo-2'-deoxyuridine (BrdU) labeling and subsequent histology or immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c06b2b4a55408822eb91fc73e4e9439
https://doi.org/10.3389/fnins.2011.00067

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Background migration of USPIO/MLs is a major drawback for in situ labeling of endogenous neural progenitor cells

Autor: Annemie Van der Linden, Marcel De Cuyper, Ruth Vreys, Stefaan J. Soenen

Publikováno v: Contrast media and molecular imaging

MR-labeling of endogenous neural progenitor cells (NPCs) to follow up cellular migration with in vivo magnetic resonance imaging (MRI) is a very promising tool in the rapidly growing field of cellular imaging. To date, most of the in situ labeling wo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe04065b13eb92a66163d068ed92955a
https://pubmed.ncbi.nlm.nih.gov/20648643

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MRI visualization of endogenous neural progenitor cell migration along the RMS in the adult mouse brain: validation of various MPIO labeling strategies

Autor: Ruth Vreys, Marleen Verhoye, Michiel Vellema, Veerle Baekelandt, Olga Krylychkina, Greetje Vande Velde, Annemie Van der Linden, Jean-Pierre Timmermans

Publikováno v: Neuroimage

The adult rodent brain contains neural progenitor cells (NPCs), generated in the subventricular zone (SVZ), which migrate along the rostral migratory stream (RMS) towards the olfactory bulb (OB) where they differentiate into neurons. The aim of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9409dd3612341459918b0539fbc3c6
https://pubmed.ncbi.nlm.nih.gov/19850132

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Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with microSPECT and quantitative MRI

Autor: Annemie Van der Linden, Cindy Casteels, Jan Sijbers, Luc Mortelmans, Veerle Baekelandt, Koen Van Laere, Ruth Vreys, Johan Nuyts, Erwin Lauwers, Alfons Verbruggen, Nadja Van Camp, D. Beque, Zeger Debyser, Marleen Verhoye

Publikováno v: Magnetic resonance materials in physics, biology and medicine

In the present study, we aimed to evaluate the impact of neurodegeneration of the nigrostriatal tract in a rodent model of Parkinson's disease on the different MR contrasts (T(2), T(1), CBF and CBV) measured in the striatum. Animals were injected wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfaa5f237df61e9f4904e14a97cdd96
https://pubmed.ncbi.nlm.nih.gov/20169465

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