Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ruth U. Pendlington"'
Autor:
Leanne Page, Ruth U. Pendlington, David J. Sanders, Clare Bourner, Cameron MacKay, Michael Davies, Clive Roper, Camilla Pease
Publikováno v:
Toxicological Sciences. 119:308-318
Development of risk assessment methods for skin sensitization in the absence of toxicological data generated in animals represents a major scientific and technical challenge. The first step in human skin sensitization induction is the transport of se
Autor:
David J. Sanders, Leanne Stupart, Clive Roper, Cameron MacKay, Ruth U. Pendlington, Camilla Pease, Helen J Minter
Publikováno v:
Cutaneous and Ocular Toxicology. 27:283-294
In vitro skin absorption methods exist in Organisation for Economic Co-operation and Development (OECD) guideline form (No. 428) and are used to estimate the degree of systemic penetration of chemicals through skin. More detailed kinetics of permeati
Autor:
Ruth U. Pendlington, Hans F. Merk, Sue Gibbs, Camilla K. Pease, David J. Lockley, Johannes J.M. van de Sandt
Publikováno v:
Gibbs, S, van de Sandt, J J M, Merk, H F, Lockley, D J, Pendlington, R U & Pease, C K 2007, ' Xenobiotic metabolism in human skin and 3D human skin reconstructs : A review ', Current Drug Metabolism, vol. 8, no. 8, pp. 758-772 . https://doi.org/10.2174/138920007782798225
In this review, we discuss and compare studies of xenobiotic metabolism in both human skin and 3D human skin reconstructs. In comparison to the liver, the skin is a less studied organ in terms of characterising metabolic capability. While the skin fo
Autor:
Camilla Pease, Ruth U. Pendlington, Elizabeth J. Brown, Mary Snow, David J. Sanders, Simon Hyde, Helen M. Minter
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 22:117-124
Diethylenetriaminepenta-acetic acid (DTPA) is a metal ion-chelating agent that has antimicrobial properties and potential therapeutic properties against metal-induced toxicities such as nickel allergy. In this study, the absorption properties of DTPA
Autor:
Eleanor Y. M. Bonnist, Jean-Phillipe Gorce, Cameron MacKay, Ruth U. Pendlington, Paul D. A. Pudney, P. M. Champion, L. D. Ziegler
Publikováno v:
AIP Conference Proceedings.
Publikováno v:
Toxicology. 231:107-108
Publikováno v:
Toxicology Letters. 172:S152
Autor:
L. Stupart, Ruth U. Pendlington, Cameron MacKay, Clive Roper, David Sanders, Camilla Pease, Helen M. Minter
Publikováno v:
Toxicology Letters. 172:S106
Autor:
Christopher C. Rowlands, Ruth U. Pendlington, Martin D. Barratt, Jonathan N. Delahanty, Jeffrey C. Evans
Publikováno v:
Biochemical Pharmacology. 38:3879-3883
The photochemical reactions of the bacteriocide bithionol (a known photoallergen in man) with soluble proteins and peptides, were investigated. Solutions of human serum albumin (HSA), human gamma-globulin, bovine insulin and poly-L-lysine were irradi
Autor:
Ruth U. Pendlington, Christopher C. Rowlands, Jeffrey C. Evans, Martin D. Barratt, Jonathan N. Delahanty
Publikováno v:
Free radical biologymedicine. 7(3)
Aqueous solutions (pH = 8) of both 3,3'-dimethyl and 4,4'-dimethyl substituted analogues of the photoallergen fentichlor (bis(2-hydroxy-5-chlorophenyl)sulphide) produced stable semiquinone radicals when irradiated with u.v. light (greater than 310 nm