Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Ruth Sepper"'
1
Akademický článek
Understanding drug uptake and binding within targeted disease micro‐environments in patients: a new tool for translational medicine
Autor: György Marko‐Varga, Ákos Végvári, Melinda Rezeli, Kaiu Prikk, Peeter Ross, Magnus Dahlbäck, Goutham Edula, Ruth Sepper, Thomas E Fehniger
Publikováno v: Clinical and Translational Medicine, Vol 1, Iss 1, Pp n/a-n/a (2012)
Abstract Background For many common global diseases, such as cancer, diabetes, neurodegenerative and cardiovascular diseases there is an unmet need for diagnosing early indications of disease that could enable medical intervention and early treatment
Externí odkaz: https://doaj.org/article/c8b302973ae64062b1c4d42d10464603
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2
Akademický článek
Role of politics in public sector organizational change
Autor: Ruth Sepper, Ruth Alas
Publikováno v: Journal of Business Economics and Management, Vol 9, Iss 1 (2008)
In this paper we will address issues of organizational changes in public sector where the relevance of management has not diminished during the last two decades of the neo‐liberal market philosophy. Public sector organizations are susceptible to gr
Externí odkaz: https://doaj.org/article/4d47ac3994ad4fcfb5168feb58a93943
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3
Telemonitoring in Chronic Obstructive Pulmonary Disease (CHROMED). A Randomized Clinical Trial
Autor: Trine S Bergmo, Jo Middlemass, Ramon Farré, Andrei Malinovschi, Dorjan Marušič, Christer Janson, Giulia Munaro, Roberto Rosso, Ruth Sepper, Pasquale P. Pompilio, Josep M. Montserrat, Kaiu Prikk, Peter M.A. Calverley, Paul Walker, Silvana Šonc, Raffaele Dellaca, A Niroshan Siriwardena, Paolo Zanaboni
Publikováno v: American Journal of Respiratory and Critical Care Medicine. 198:620-628
Early detection of chronic obstructive pulmonary disease (COPD) exacerbations using telemonitoring of physiological variables might reduce the frequency of hospitalization.To evaluate the efficacy of home monitoring of lung mechanics by the forced os
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70b66459a1e692700d9a446cf37c76d
https://doi.org/10.1164/rccm.201712-2404oc
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5
Mucin5B expression by lung alveolar macrophages is increased in long-term smokers
Autor: Thomas E. Fehniger, Olga Bragina, Kaiu Prikk, Sirje Marran, Natalia Pugatsjova, Svetlana Sergejeva, Ruth Sepper, Madis Metsis
Publikováno v: Journal of Leukocyte Biology. 92:319-324
Mucin5B is expressed in alveolar macrophages in long-term smokers who have developed smoking associated lung diseases. This study investigated the expression of MUC5B by AMs in the lungs of cigarette smokers and nonsmokers. We analyzed MUC5B expressi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25e25b843e336ac235bc8624d6f9e45
https://doi.org/10.1189/jlb.0111047
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6
Direct Demonstration of Tissue Uptake of an Inhaled Drug: Proof-of-Principle Study Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging
Autor: Ákos Végvári, György Marko-Varga, Kaiu Prikk, Ruth Sepper, Magnus Dahlbäck, Peeter Ross, Melinda Rezeli, Goutham Edula, Thomas E. Fehniger
Publikováno v: Analytical Chemistry. 83:8329-8336
Drug therapy is often directed to specific organ and tissue compartments where the mode of action of the compound affects specifically targeted biological processes. However, the direct measurement of drug uptake in terms of a time kinetic and concen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bc4a2a981537ac369a85c1b1f53c53
https://doi.org/10.1021/ac2014349
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9
Bupropion SR vs Placebo for Smoking Cessation in Health Care Professionals
Autor: Jean-Pierre Zellweger, Amy Z Hider, Ruth Sweet, Pal Laszio Boelcskei, Ruth Sepper, Laura Carrozzi
Publikováno v: American Journal of Health Behavior. 29:240-249
Objective To evaluate bupropion SR for smoking cessation in physicians and nurses. Methods This double-blind prospective 26-center, 12-country trial randomized 687 subjects to smoking cessation counselling with bupropion SR or placebo for 7 weeks. Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ca8b7103fa4bea3b534865962151b5
https://doi.org/10.5993/ajhb.29.3.5
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10
Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers
Autor: Ruth Sepper, Malcolm Shepherd, Rachael Barber, Reinhard Bergmann, George S. Baillie, Miles D. Houslay, Gino Van Heeke
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 287:L332-L343
The expression profile of a panel of 15 cAMP phosphodiesterase isoforms was determined for inflammatory cell types of relevance to chronic obstructive pulmonary disease (COPD). In particular, the expression profiles for bronchoalveolar macrophages, p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9d3214d9bb377edc2784cd87a30dd2
https://doi.org/10.1152/ajplung.00384.2003
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