A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment.

Autor: Silvia Cruz-Gil, Ruth Sánchez-Martínez, Sonia Wagner-Reguero, Daniel Stange, Sebastian Schölch, Kristin Pape, Ana Ramírez de Molina

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0219944 (2019)

Precision medicine might be the response to the recent questioning of the use of metformin as an anticancer drug in colorectal cancer (CRC). Thus, in order to establish properly its benefits, metformin application needs to be assayed on the different

Externí odkaz: https://doaj.org/article/c0912f0b6b284595be691aebd5116db0

Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer

Autor: Ruth Sánchez-Martínez, Juan Moreno-Rubio, Marta Gómez de Cedrón, Adriana Quijada-Freire, Enrique Casado, Guillermo Reglero, María Sereno, María Merino, Lara P. Fernández, Ana Ramírez de Molina, Gonzalo Colmenarejo

Publikováno v: Molecular Oncology

Overexpression of the enzyme ACSL3 is an unfavorable prognostic marker in non‐small cell lung cancer (NSCLC). Moreover, overexpression of ACSL3 increases cell proliferation, migration, and invasion, altering the metabolic properties of cancer cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2396f5cfaf1fd5db364069b3d761b854
https://pubmed.ncbi.nlm.nih.gov/33030783

The role of glycosyltransferase enzyme GCNT3 in colon and ovarian cancer prognosis and chemoresistance

Autor: Jaime Feliu, Lara P. Fernández, Teodoro Vargas, Jesús Herranz, Guillermo Reglero, Andrés Redondo, Roberto Martín-Hernández, Ruth Sánchez-Martínez, Ana Ramírez de Molina, Marta Mendiola, David Hardisson

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Glycosyltransferase enzyme GCNT3, has been proposed as a biomarker for prognosis in colorectal cancer (CRC). Our study goes in depth into the molecular basis of GCNT3 role in tumorigenesis and drug resistance, and it explores its potential role as bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e38d078cdf6d60a72d783b38c1c6e0
http://link.springer.com/article/10.1038/s41598-018-26468-4

Lipid metabolism and lung cancer

Autor: Enrique Casado, Ruth Sánchez Martínez, Sandra Falagán Martínez, Juan Moreno Rubio, María Sereno, Ana Ramírez de Molina, Marta Gómez de Cedrón, María Merino Salvador

Publikováno v: Critical Reviews in Oncology/Hematology. 112:31-40

Lung cancer is currently one of the most serious health issues in developed and developing countries. There are multiple available treatment options; however survival still remains very poor. Despite metabolism alteration being one of the hallmarks d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ade83de938481e6d0d135553c0a713a
https://doi.org/10.1016/j.critrevonc.2017.02.001

A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment

Autor: Sebastian Schölch, Sonia Wagner-Reguero, Ruth Sánchez-Martínez, Daniel E. Stange, Kristin Pape, Silvia Cruz-Gil, Ana Ramírez de Molina

Publikováno v: PLoS ONE, Vol 14, Iss 9, p e0222819 (2019)
PLoS ONE

Precision medicine might be the response to the recent questioning of the use of metformin as an anticancer drug in colorectal cancer (CRC). Thus, in order to establish properly its benefits, metformin application needs to be assayed on the different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbacd5eb4e247c6a0e74dfd8bf20bce
https://doaj.org/article/2d221afae4874fc0825362a8eb44d303