Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ruth Rott"'
Autor:
Raymonde Szargel, Rina Bandopadhyay, Haya Hamza, Vered Shani, Mor Savyon, Ruth Rott, Fatimah Abd Elghani, Simone Engelender
Publikováno v:
Proceedings of the National Academy of Sciences. 114:13176-13181
α-Synuclein accumulation is a pathological hallmark of Parkinson's disease (PD). Ubiquitinated α-synuclein is targeted to proteasomal or lysosomal degradation. Here, we identify SUMOylation as a major mechanism that counteracts ubiquitination by di
Autor:
Diana G. Ferreira, Wei Xiang, Hugo Vicente Miranda, Nuno C. Santos, Luís M. A. Oliveira, Irina Zamolo, Deborah Penque, Olaf Riess, Ruth Rott, Flaviano Giorgini, Carlos Cordeiro, Márcia Oliveira, Marcos António Gomes, Ekrem Darendelioglu, Luísa V. Lopes, Tiago F. Outeiro, Carlo Breda, Alexandre Quintas, Eva F. Rodrigues, Éva M. Szegő, Markus Zweckstetter, Hilal A. Lashuel, Michael Heinrich, Tânia Simões, Rita Oliveira, Ivo C. Martins, Thomas M. Jovin, Francisco J. Enguita, Jochen Klucken, Francesca Munari, Simone Engelender, Ana Ponces-Freire
Publikováno v:
Brain. 144:e58-e58
Autor:
Mor Savyon, Fatimah Abd Elghani, Ruth Rott, Kah-Leong Lim, Tsipora Cohen, Rina Bandopadhyay, Ninghan Wang, Raymonde Szargel, Simone Engelender, Vered Shani, Lihi Shaulov, Christopher A. Ross, Hazem Safory, Hui Zhang, Inna Radzishevsky, Haya Hamza
Publikováno v:
Hum Mol Genet
Mutations in LRRK2 cause autosomal dominant and sporadic Parkinson’s disease, but the mechanisms involved in LRRK2 toxicity in PD are yet to be fully understood. We found that LRRK2 translocates to the nucleus by binding to seven in absentia homolo
Autor:
Carlos Cordeiro, Luís M. A. Oliveira, Ruth Rott, Deborah Penque, Tania Simões, Michael Heinrich, Francesca Munari, Ekrem Darendelioglu, Olaf Riess, Carlo Breda, Diana G. Ferreira, Thomas M. Jovin, Rita Machado de Oliveira, Luísa V. Lopes, Eva F. Rodrigues, Ivo C. Martins, Hugo Vicente Miranda, Jochen Klucken, Markus Zweckstetter, Hilal A. Lashuel, Alexandre Quintas, Márcia Oliveira, Nuno C. Santos, Marcos António Gomes, Tiago F. Outeiro, Irina Zamolo, Wei Xiang, Simone Engelender, Ana Ponces-Freire, Francisco J. Enguita, Éva M. Szegö, Flaviano Giorgini
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Brain
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
Brain 140(5), 1399-1419 (2017). doi:10.1093/brain/awx056
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Brain
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
Brain 140(5), 1399-1419 (2017). doi:10.1093/brain/awx056
© The Author (2017). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.
α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases kn
α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50ba62720be24e704cb583505996af7
Publikováno v:
Chemistry & Biology. 20(10):1207-1213
Summary The formation of toxic aggregates composed largely of the protein α-synuclein are a hallmark of Parkinson's disease. Evidence from both early-onset forms of the disease in humans and animal models has shown that the progression of the diseas
Autor:
Simone Engelender, Raymonde Szargel, Vered Shani, Esti Liani, Lucy N. Mekies, Fatimah Abd Elghani, Ruth Rott
Publikováno v:
Human molecular genetics. 25(16)
PTEN-induced putative kinase 1 (PINK1) and parkin are mutated in familial forms of Parkinson's disease and are important in promoting the mitophagy of damaged mitochondria. In this study, we showed that synphilin-1 interacted with PINK1 and was recru
Autor:
Vered Shani, Andrew J. Lees, Raymonde Szargel, Ruth Rott, Simone Engelender, Joseph Haskin, Rina Bandopadhyay
Publikováno v:
Proceedings of the National Academy of Sciences. 108:18666-18671
α-Synuclein is central to the pathogenesis of Parkinson disease (PD). Mutations as well as accumulation of α-synuclein promote the death of dopaminergic neurons and the formation of Lewy bodies. α-Synuclein is monoubiquitinated by SIAH, but the re
Autor:
Eyal Avraham, Ruth Rott, Raymonde Szargel, Alla Shainskaya, Irena Manov, Simone Engelender, Joseph Haskin, Esti Liani, Vered Shani
Publikováno v:
Journal of Biological Chemistry. 283:3316-3328
alpha-Synuclein plays a major role in Parkinson disease. Unraveling the mechanisms of alpha-synuclein aggregation is essential to understand the formation of Lewy bodies and their involvement in dopaminergic cell death. alpha-Synuclein is ubiquitylat
Publikováno v:
Journal of Biological Chemistry. 282:12842-12850
Mutations in Parkin are responsible for a large percentage of autosomal recessive juvenile parkinsonism cases. Parkin displays ubiquitin-ligase activity and protects against cell death promoted by several insults. Therefore, regulation of Parkin acti
Publikováno v:
Journal of Biological Chemistry. 280:42877-42886
α-Synuclein is known to play a major role in the pathogenesis of Parkinson disease. We previously identified synphilin-1 as an α-synuclein-interacting protein and more recently found that synphilin-1 also interacts with the E3 ubiquitin ligases SIA