Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ruth R. Osborn"'
Autor:
Xichen Lin, Michael E. Muratore, Huijie Li, Ami S. Lakdawala, Jakob Busch-Petersen, Ruth R. Osborn, David D. Miller, Jeffrey K. Kerns, Rick P. C. Cousins, Ian Robert Baldwin, Paul Bamborough, John Yonchuk, Ann M. Bullion, Lin Guoliang, Jeffrey C. Boehm, Wei Fu, John A. Christopher, Edward F. Webb, Roderick S. Davis, William L. Rumsey, Rita Field, Jeremy John Payne, Hong Nie
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1164-1169
[Image: see text] IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782cb7b7a63c400db0be5e5461917822
https://doi.org/10.1021/acsmedchemlett.8b00291
https://doi.org/10.1021/acsmedchemlett.8b00291
Autor:
Heather Hobbs, Rick P. C. Cousins, Caroline Whitworth, Ruth R. Osborn, Cesar Ramirez-Molina, Giorgia Vicentini, Chris Ioannou, Chun-wa Chung, Jeremy John Payne, Michelle L. Heathcote, Michael David Barker, Sebastien Andre Campos, Paul Faulder, Mary A. Morse, William L. Rumsey, John Liddle, Daniel Terence Tape, John Martin Pritchard, Rick Williamson, Duncan S. Holmes, Paul Bamborough
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5222-5226
The lead optimization of a series of potent azaindole IKK2 inhibitors is described. Optimization of the human whole blood activity and selectivity over IKK1 in parallel led to the discovery of 16, a potent and selective IKK2 inhibitor showing good ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c01094b7cd1f9f02ade498d99ac86e
https://doi.org/10.1016/j.bmcl.2012.06.065
https://doi.org/10.1016/j.bmcl.2012.06.065
Autor:
Joseph P. Foley, Steven R. Katchur, Alicia Bacon Davis, Patricia L. Podolin, Pearl L. Flamberg, William L. Rumsey, Brian Bolognese, Ruth R. Osborn, Charles J. Kotzer
Publikováno v:
Mutagenesis. :gew063
Inhalation of airborne toxicants such as cigarette smoke and ozone is a shared health risk among the world's populations. The use of toxic herbicides like paraquat (PQ) is restricted by many countries, yet in the developing world PQ has demonstrable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c461e63d4bff1ad26e6eb0bfbe3e80
https://doi.org/10.1093/mutage/gew063
https://doi.org/10.1093/mutage/gew063
Autor:
David C. Underwood, Steven Bochnowicz, Ruth R. Osborn, Calvert Louden, Timothy K. Hart, Eliot H. Ohlstein, Douglas W. P. Hay
Publikováno v:
Journal of Cardiovascular Pharmacology. 31:S453-S455
The cardiopulmonary profile of three different rat strains was compared after exposure to hypoxia (9% O2) for 0, 7, or 14 days. In Sprague-Dawley (SD), Wistar (W), and high altitude-sensitive (HAS) rats, pulmonary arterial pressure (PAP) rose 30, 58,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800d3c194d9d83e6ae098d933f5cd437
https://doi.org/10.1097/00005344-199800001-00129
https://doi.org/10.1097/00005344-199800001-00129
Autor:
Anne M. Romanic, Steven Bochnowicz, Edward F. Webb, John C. Lee, Don E. Griswold, Douglas W. P. Hay, David C. Underwood, Ruth R. Osborn, David J. Rieman, Jerry L. Adams
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 279(5)
The effects of a second generation p38 mitogen-activated protein kinase (MAPK) inhibitor, SB 239063 [ trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole; IC50 = 44 nM vs. p38α], were assessed in models that repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549277c4c8c371b54db514084aca80a4
https://pubmed.ncbi.nlm.nih.gov/11053025
https://pubmed.ncbi.nlm.nih.gov/11053025
Autor:
Ruth R. Osborn, Calvert Louden, Tim Hart, Douglas W. P. Hay, David C. Underwood, Steven Bochnowicz, Mark A. Luttmann
Publikováno v:
Clinical and experimental hypertension (New York, N.Y. : 1993). 22(5)
The cardiopulmonary profile of three rat strains (Sprague-Dawley, Wistar and High altitude-sensitive) was compared upon exposure to hypoxia (9% O2) for 0, 7 or 14 days. No differences were observed among the in vitro contractile (ET-1) and relaxant (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d816d1ce128a29b5d30b2b65a13ec4
https://pubmed.ncbi.nlm.nih.gov/10937839
https://pubmed.ncbi.nlm.nih.gov/10937839
Publikováno v:
International archives of allergy and immunology. 117(1)
The aim of this study was to measure the effects of food restriction on antigen–induced bronchoconstriction and inflammatory cell influx in guinea pigs and to determine the role of plasma cortisol and catecholamine concentrations. Ovalbumin (OA; 0.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19beab3fcbf6e192b9f8863ac89811d4
https://pubmed.ncbi.nlm.nih.gov/9751848
https://pubmed.ncbi.nlm.nih.gov/9751848
Autor:
Barry M. Weichman, M A Wasserman, Barry A. Berkowitz, John G. Gleason, Bogdan Zabko-Potapovich, Thomas W. Ku, Mary E. McCarthy, Ruth R. Osborn, David A. Holden
Publikováno v:
Biochemical and Biophysical Research Communications. 117:732-739
A structural analog of LTD4, 4R-hydroxy-5S-cysteinylglycyl-6Z-nonadecenoic acid (4R, 5S, 6Z-2-nor-LTD1) has been synthesized and pharmacologically characterized. It significantly antagonized the contractile action of LTD4, LTC4 and LTE4 in guinea pig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742f00b3bd33c278fb4b018bcbab1acf
https://doi.org/10.1016/0006-291x(83)91658-3
https://doi.org/10.1016/0006-291x(83)91658-3
Publikováno v:
Prostaglandins. 22:423-432
The activity of the SRS-A antagonist FPL 55712 against histamine, carbachol and ion-induced contraction of isolated airway smooth muscle was evaluated. FPL 55712 enhanced responses of guinea-pig trachea and parenchymal lung strips to histamine and ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db4a6bd9f54bd71cb8c68b6e3a8a870
https://doi.org/10.1016/0090-6980(81)90103-9
https://doi.org/10.1016/0090-6980(81)90103-9
Autor:
Robert D. Krell, K. Falcone, Lynne M. Vickery, M. O'Donnell, Ruth R. Osborn, Charles M. Kinzig, John G. Gleason, Deborah Lynn Bryan
Publikováno v:
Prostaglandins. 22:387-409
The pharmacology of leukotrienes (LT) C4 and D4 in isolated airway smooth muscle was investigated. In rat trachea, neither LTC4 or D4 elicited a response. In contrast, LTC4 was a potent contractile agonist in guinea-pig trachea, bronchus and parenchy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffa774e90ec0abc03c18118bf47ef51
https://doi.org/10.1016/0090-6980(81)90101-5
https://doi.org/10.1016/0090-6980(81)90101-5