Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Ruth R Wexler"'
Autor:
E. Scott Priestley, Jacques Banville, Daniel Deon, Laurence Dubé, Marc Gagnon, Julia Guy, Philippe Lapointe, Jean-François Lavallée, Alain Martel, Serge Plamondon, Roger Rémillard, Edward Ruediger, François Tremblay, Shana L. Posy, Victor R. Guarino, Jeremy M. Richter, Jianqing Li, Anuradha Gupta, Muthalagu Vetrichelvan, T. J. Balapragalathan, Arvind Mathur, Ji Hua, Mario Callejo, Jocelyne Guay, Chi Shing Sum, Mary Ellen Cvijic, Carol Watson, Pancras Wong, Jing Yang, Michel Bouvier, David A. Gordon, Ruth R. Wexler, Anne Marinier
Publikováno v:
Journal of Medicinal Chemistry. 65:8843-8854
Protease-activated receptor 4 (PAR4) is a G-protein coupled receptor that is expressed on human platelets and activated by the coagulation enzyme thrombin. PAR4 plays a key role in blood coagulation, and its importance in pathological thrombosis has
Autor:
Nicholas R. Wurtz, James A. Johnson, Andrew Viet, Pravin S. Shirude, Vishweshwaraiah Baligar, Sudhakara Madduri, Daniel L. Cheney, Hyunsoo Park, John A. Lupisella, Mei-Yin Hsu, Mojgan Abousleiman, Michael A. Galella, Darpandeep Aulakh, Elizabeth A. Dierks, Ricardo A. Garcia, Jacek Ostrowski, Ellen K. Kick, Ruth R. Wexler
Publikováno v:
ACS Med Chem Lett
[Image: see text] Formyl peptide receptor 2 (FPR2) agonists have shown efficacy in inflammatory-driven animal disease models and have the potential to treat a range of diseases. Many reported synthetic agonists contain a phenylurea, which appears to
Autor:
Jeffrey M. Bozarth, Pancras C. Wong, Earl J. Crain, William R. Ewing, Joseph M. Luettgen, David A. Gordon, Ruth R. Wexler, Yiming Wu, Dilger Andrew K
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:399-408
BACKGROUND Milvexian (BMS-986177/JNJ-70033093) is an orally bioavailable factor XIa (FXIa) inhibitor currently in phase 2 clinical trials. OBJECTIVES To evaluate in vitro properties and in vivo characteristics of milvexian. METHODS In vitro propertie
Autor:
Zilun Hu, Doree Sitkoff, Peter W. Glunz, Yan Zou, Cailan Wang, Jodi K. Muckelbauer, Leonard P. Adam, Ruth R. Wexler, Mimi L. Quan
Publikováno v:
SSRN Electronic Journal.
Autor:
Wei Meng, Heather Finlay, Claudia Generaux, Chiuwa E. Luk, Tao Wang, Robert Paul Brigance, Joelle M. Onorato, Peter S. Gargalovic, Ruth R. Wexler, William A. Schumacher, Jeffrey S. Bostwick, Zulan Pi, Karen A. Rossi
Publikováno v:
Journal of Medicinal Chemistry. 64:18102-18113
This paper describes our continued efforts in the area of small-molecule apelin receptor agonists. Recently disclosed compound 2 showed an acceptable metabolic stability but demonstrated monodemethylation of the dimethoxyphenyl group to generate atro
Autor:
Ruth R. Wexler, Kenneth G. Mann, Leonard M. Milstone, Rodney M. Camire, Jeremy P. Wood, Wolfram Ruf, Robert M. Knabb, Richard C. Becker, Craig M Jackson
Publikováno v:
Journal of Thrombosis and Thrombolysis
Autor:
Ruth R. Wexler, Robert M. Knabb
Publikováno v:
Journal of Thrombosis and Thrombolysis. 52:403-407
Over the past few decades, drug discovery directed at the treatment and prevention of thromboembolic diseases has been challenged by the need to balance robust efficacy with improved safety relative to the standard of care. To this end, the most impa
Autor:
Jeremy M. Richter, J. Alex Bates, Peter Gargalovic, Joelle M. Onorato, Claudia Generaux, Tao Wang, David A. Gordon, Ruth R. Wexler, Heather J. Finlay
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
Agonism of the apelin receptor (APJ) has demonstrated beneficial effects in models of heart failure. We have previously disclosed compounds such as 4, which showed good APJ agonist activity but were metabolized to the mono-demethylated, non-interconv
Autor:
Arunachalam Arumugam, Dietmar A. Seiffert, Arvind Mathur, Joanna J. Zheng, Ruth R. Wexler, Jeon Yoon T, Premsai Rai Neithnadka, Earl J. Crain, Paul J. Gilligan, Patrick Y.S. Lam, Yiming Wu, Mahammed Kaspady, Pancras C. Wong, Tianan Fang, Silvi A. Chacko, William R. Ewing, Pabbisetty Kumar Balashanmuga, Zhen Lou, Steven Sheriff, Joseph M. Luettgen, Joseph E. Myers, Wu Yang, Karen A. Rossi, Richard Rampulla, James R. Corte, Amy Lai, Charles G. Clark, Jeffrey M. Bozarth, Yufeng Wang, Sivashankaran Raju
Publikováno v:
Journal of Medicinal Chemistry. 63:7226-7242
Oral factor XIa (FXIa) inhibitors may provide a promising new antithrombotic therapy with an improved benefit to bleeding risk profile over existing antithrombotic agents. Herein, we report application of a previously disclosed cyclic carbamate P1 li
Autor:
William A. Schumacher, Yan He, Peter S. Gargalovic, Tao Wang, Joelle M. Onorato, Ruth R. Wexler, James A. Johnson, Zulan Pi, Claudia Generaux, Wei Meng, Heather Finlay, David A. Gordon, Monique Phillips, Jeffrey S. Bostwick
Publikováno v:
ACS Med Chem Lett
[Image: see text] The apelin receptor (APJ) is a significant regulator of cardiovascular function and is involved in heart failure and other cardiovascular diseases. (Pyr(1))apelin-13 is one of the endogenous agonists of the APJ receptor. Administrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c497839aa78ba246784ea2c27101a0c
https://europepmc.org/articles/PMC8591725/
https://europepmc.org/articles/PMC8591725/