Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ruth Röck"'
Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies
Autor:
Eduard Stefan, Omar Torres-Quesada, Egon Ogris, Johanna E. Mayrhofer, Philipp Tschaikner, Andreas Feichtner, Florian Enzler, Andrea Raffeiner, Jakob Troppmair, Markus Hartl, Rainer Schneider, Roland G. Huber, Ruth Röck, Jakob Fleischmann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The pharmaceutical targeting of mutated BRAF has shown promising clinical outcomes in patients with melanoma. However, more than 300 reported BRAF patient mutations and the occurrence of a kinase-drug resistance mechanism hamper patient-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd40c2c1fcc0d48064d424aa4bada7f
https://doi.org/10.1073/pnas.2012150117
https://doi.org/10.1073/pnas.2012150117
Publikováno v:
Physiology (Bethesda, Md.). 37(4)
The kidney is a complex organ, and how it forms is a fascinating process. New technologies, such as single-cell transcriptomics, and enhanced imaging modalities are offering new approaches to understand the complex and intertwined processes during em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220250535b1cc39bb4d731d61c636c49
https://pubmed.ncbi.nlm.nih.gov/35253460
https://pubmed.ncbi.nlm.nih.gov/35253460
Autor:
Thomas C. Schwarz, Karin Ledolter, Eduard Stefan, Ruth Röck, Andrea Schraffl, Robert Konrat, Markus Hartl, Klaus Bister, Philipp Raffeiner
Publikováno v:
Oncotarget
// Philipp Raffeiner 1, 3 , Andrea Schraffl 1 , Thomas Schwarz 2 , Ruth Rock 1 , Karin Ledolter 2 , Markus Hartl 1 , Robert Konrat 2 , Eduard Stefan 1 , Klaus Bister 1 1 Institute of Biochemistry and Center for Molecular Biosciences, University of In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc649fee22bd477f815502c6f95a7d5
https://doi.org/10.18632/oncotarget.13759
https://doi.org/10.18632/oncotarget.13759
Autor:
Omar Torres-Quesada, Jakob Troppmair, Ruth Röck, Eduard Stefan, Johanna E. Mayrhofer, Florian Enzler
Publikováno v:
Molecular Cancer Research. 18:B45-B45
Live-cell recordings of protein conformations and interactions yield novel mechanistic insights into physiologic and pathologic protein functions. We have developed an adaptable and genetically encoded bioluminescence-based biosensor platform to prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70cb9c08bca0831fde7b3326e20a928a
https://doi.org/10.1158/1557-3125.ras18-b45
https://doi.org/10.1158/1557-3125.ras18-b45
Autor:
Ruth, Röck, Johanna E, Mayrhofer, Omar, Torres-Quesada, Florian, Enzler, Andrea, Raffeiner, Philipp, Raffeiner, Andreas, Feichtner, Roland G, Huber, Shohei, Koide, Susan S, Taylor, Jakob, Troppmair, Eduard, Stefan
Publikováno v:
Science Advances
Patient mutation–specific BRAF inhibitors alter full-length kinase conformations and promote interactions with GTP-loaded RAS.
Oncogenic BRAF mutations initiate tumor formation by unleashing the autoinhibited kinase conformation and promoting
Oncogenic BRAF mutations initiate tumor formation by unleashing the autoinhibited kinase conformation and promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca62fb6e6204b702f6df0896a96391ba
https://pubmed.ncbi.nlm.nih.gov/31453322
https://pubmed.ncbi.nlm.nih.gov/31453322
Publikováno v:
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 49(4)
The diffusible second messenger cyclic AMP (cAMP) originates from multiple G protein-coupled receptor (GPCR) cascades activating the intracellular key effector protein kinase A (PKA). Spatially and temporally restricted cAMP-fluxes are directly sense
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f1738ac4adb17a7bb221c914fd0d6b
https://pubmed.ncbi.nlm.nih.gov/28427097
https://pubmed.ncbi.nlm.nih.gov/28427097
Autor:
Susan S. Taylor, Jian Wu, Jessica G.H. Bruystens, Eduard Stefan, Audrey Fortezzo, Ruth Röck, Cole Nielsen, Jason C. Del Rio, Donald K. Blumenthal
Publikováno v:
Journal of molecular biology, vol 428, iss 24 Pt B
Most disease-related mutations that impair cAMP protein kinase A (PKA) signaling are present within the regulatory (R) PKA RI alpha-subunit (RIα). Although mutations in the PRKAR1A gene are linked to Carney complex (CNC) disease and, more recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f145b143134c2192234238d6d41e420c
https://europepmc.org/articles/PMC5149412/
https://europepmc.org/articles/PMC5149412/
Autor:
Verena Bachmann, Eduard Stefan, Federico Apelt, Philipp Raffeiner, Tsan-Wen Lu, Pierre Thibault, George S. Baillie, Mathieu Courcelles, Susan S. Taylor, Johanna E. Mayrhofer, Ronit Ilouz, Ulrich Stelzl, Philipp Tschaikner, Ruth Röck, Pia Aanstad
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(28)
Scaffolding proteins organize the information flow from activated G protein-coupled receptors (GPCRs) to intracellular effector cascades both spatially and temporally. By this means, signaling scaffolds, such as A-kinase anchoring proteins (AKAPs), c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739e92dd6cbf00b209f5dc4e2e1725c8
https://pubmed.ncbi.nlm.nih.gov/27357676
https://pubmed.ncbi.nlm.nih.gov/27357676
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Figure 5. Impact of RIa mutations and cAMP elevation on PKA type I complexes. . . . (B) Following indicated modifications of RIa-F[1] sequences, combinations of wild type and mutant Rluc PCA tagged PKA subunits have been subjected to Rluc PCA measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3387ac261658843d506a8df2c14ca675
https://doi.org/10.3389/fphar.2015.00214
https://doi.org/10.3389/fphar.2015.00214
Autor:
Ruth Röck, Verena Bachmann, Hyo-eun C Bhang, Mohan Malleshaiah, Philipp Raffeiner, Johanna E Mayrhofer, Philipp M Tschaikner, Klaus Bister, Pia Aanstad, Martin G Pomper, Stephen W Michnick, Eduard Stefan
Publikováno v:
Scientific Reports
Membrane receptor-sensed input signals affect and modulate intracellular protein-protein interactions (PPIs). Consequent changes occur to the compositions of protein complexes, protein localization and intermolecular binding affinities. Alterations o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5a6e8b1b25cde50aa4b3738918f8f012
http://europepmc.org/articles/PMC4477410
http://europepmc.org/articles/PMC4477410