Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ruth Pidsley"'
Autor:
Timothy J. Peters, Braydon Meyer, Lauren Ryan, Joanna Achinger-Kawecka, Jenny Song, Elyssa M. Campbell, Wenjia Qu, Shalima Nair, Phuc Loi-Luu, Phillip Stricker, Elgene Lim, Clare Stirzaker, Susan J. Clark, Ruth Pidsley
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background The Illumina family of Infinium Methylation BeadChip microarrays has been widely used over the last 15 years for genome-wide DNA methylation profiling, including large-scale and population-based studies, due to their ease of use a
Externí odkaz:
https://doaj.org/article/6f52a85a352f46848842385dfa8f78a7
Autor:
Ruth Pidsley, Dilys Lam, Wenjia Qu, Timothy J. Peters, Phuc‐Loi Luu, Darren Korbie, Clare Stirzaker, Roger J. Daly, Phillip Stricker, James G. Kench, Lisa G. Horvath, Susan J. Clark
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 10, Pp n/a-n/a (2022)
Abstract Background Prostate cancer is a clinically heterogeneous disease with a subset of patients rapidly progressing to lethal‐metastatic prostate cancer. Current clinicopathological measures are imperfect predictors of disease progression. Epig
Externí odkaz:
https://doaj.org/article/ce0e644fc6654c8a9b89ff431e3a8d9b
Autor:
Dawn E Watkins-Chow, Joanna Cooke, Ruth Pidsley, Andrew Edwards, Rebecca Slotkin, Karen E Leeds, Raymond Mullen, Laura L Baxter, Thomas G Campbell, Marion C Salzer, Laura Biondini, Gretchen Gibney, Françoise Phan Dinh Tuy, Jamel Chelly, H Douglas Morris, Johannes Riegler, Mark F Lythgoe, Ruth M Arkell, Fabrizio Loreni, Jonathan Flint, William J Pavan, David A Keays
Publikováno v:
PLoS Genetics, Vol 11, Iss 11, p e1005682 (2015)
Externí odkaz:
https://doaj.org/article/104fd857238b4b8189cbe2fd22c7a629
Autor:
Dawn E Watkins-Chow, Joanna Cooke, Ruth Pidsley, Andrew Edwards, Rebecca Slotkin, Karen E Leeds, Raymond Mullen, Laura L Baxter, Thomas G Campbell, Marion C Salzer, Laura Biondini, Gretchen Gibney, Françoise Phan Dinh Tuy, Jamel Chelly, H Douglas Morris, Johannes Riegler, Mark F Lythgoe, Ruth M Arkell, Fabrizio Loreni, Jonathan Flint, William J Pavan, David A Keays
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003094 (2013)
The ribosome is an evolutionarily conserved organelle essential for cellular function. Ribosome construction requires assembly of approximately 80 different ribosomal proteins (RPs) and four different species of rRNA. As RPs co-assemble into one mult
Externí odkaz:
https://doaj.org/article/8fe6fb4f16a946d0a4157894bf410bd8
Autor:
Jordana T Bell, Pei-Chien Tsai, Tsun-Po Yang, Ruth Pidsley, James Nisbet, Daniel Glass, Massimo Mangino, Guangju Zhai, Feng Zhang, Ana Valdes, So-Youn Shin, Emma L Dempster, Robin M Murray, Elin Grundberg, Asa K Hedman, Alexandra Nica, Kerrin S Small, MuTHER Consortium, Emmanouil T Dermitzakis, Mark I McCarthy, Jonathan Mill, Tim D Spector, Panos Deloukas
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002629 (2012)
Age-related changes in DNA methylation have been implicated in cellular senescence and longevity, yet the causes and functional consequences of these variants remain unclear. To elucidate the role of age-related epigenetic changes in healthy ageing a
Externí odkaz:
https://doaj.org/article/c1216b10080a4acab90a7bd69e021144
Autor:
Christopher G Bell, Sarah Finer, Cecilia M Lindgren, Gareth A Wilson, Vardhman K Rakyan, Andrew E Teschendorff, Pelin Akan, Elia Stupka, Thomas A Down, Inga Prokopenko, Ian M Morison, Jonathan Mill, Ruth Pidsley, International Type 2 Diabetes 1q Consortium, Panos Deloukas, Timothy M Frayling, Andrew T Hattersley, Mark I McCarthy, Stephan Beck, Graham A Hitman
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14040 (2010)
Recent multi-dimensional approaches to the study of complex disease have revealed powerful insights into how genetic and epigenetic factors may underlie their aetiopathogenesis. We examined genotype-epigenotype interactions in the context of Type 2 D
Externí odkaz:
https://doaj.org/article/4d81a664453744d2912ef928bbd7afd7
Autor:
Braydon Meyer, Samuel Clifton, Warwick Locke, Phuc-Loi Luu, Qian Du, Dilys Lam, Nicola J. Armstrong, Beena Kumar, Niantao Deng, Kate Harvey, Alex Swarbrick, Vinod Ganju, Susan J. Clark, Ruth Pidsley, Clare Stirzaker
Publikováno v:
Clinical Epigenetics
Neoadjuvant chemotherapy (NAC) is used to treat triple-negative breast cancer (TNBC) prior to resection. Biomarkers that accurately predict a patient’s response to NAC are needed to individualise therapy and avoid chemotoxicity from unnecessary che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee739e1a2335d37c18ca06844213a93f
https://doi.org/10.1186/s13148-021-01210-6
https://doi.org/10.1186/s13148-021-01210-6
Publikováno v:
Cancers, Vol 12, Iss 2993, p 2993 (2020)
Cancers
Cancers
Simple Summary Prostate cancer is a major cause of cancer-related death in men worldwide. There is an urgent clinical need for improved prognostic biomarkers to better predict the likely outcome and course of the disease and thus inform the clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfd872b34897958d1bf25b10cb1d318
https://doi.org/10.20944/preprints202010.0154.v1
https://doi.org/10.20944/preprints202010.0154.v1
Autor:
Tran Thai Huu Loc, Phuc-Loi Luu, Clare Stirzaker, Dilys Lam, Ruth Pidsley, Susan J. Clark, Phuc-Thinh Ong
Publikováno v:
Bioinformatics
BackgroundMultiplex bisulphite PCR sequencing is a convenient and scalable method to comprehensively profile DNA methylation at selected loci. The method is useful for validation of methylation biomarker panels on large clinical cohorts, as it can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e789f096990e06b572c277c19a20bff
https://pubmed.ncbi.nlm.nih.gov/33367555
https://pubmed.ncbi.nlm.nih.gov/33367555
Autor:
Michelle Richards, Mitchell G. Lawrence, Andrew Ryan, Clare Stirzaker, Ruth Pidsley, Mark Frydenberg, Linda Teng, Melissa Papargiris, Renea A. Taylor, Sam Norden, Birunthi Niranjan, Gail P. Risbridger, Susan J. Clark, Brooke A. Pereira
Publikováno v:
Clinical Epigenetics
Background Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts (CAFs) coincide with alterati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7176beba445ad9f02e73408e9cc0764
https://doi.org/10.1186/s13148-020-00836-2
https://doi.org/10.1186/s13148-020-00836-2