Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Ruth Olmer"'
Autor:
Baxolele Mhlekude, Dylan Postmus, Saskia Stenzel, January Weiner, Jenny Jansen, Francisco J Zapatero-Belinchón, Ruth Olmer, Anja Richter, Julian Heinze, Nicolas Heinemann, Barbara Mühlemann, Simon Schroeder, Terry C Jones, Marcel A Müller, Christian Drosten, Andreas Pich, Volker Thiel, Ulrich Martin, Daniela Niemeyer, Gisa Gerold, Dieter Beule, Christine Goffinet
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011657 (2023)
Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been suggested as potential prophylactics against SARS-CoV-2 infection. However, molecular mechanisms underlying JQ-1-mediated antiviral activity and its susceptibili
Externí odkaz:
https://doaj.org/article/68f2a8478fe7484fafc679780534d4ce
Autor:
Sylvia Merkert, Alexandra Haase, Julia Dahlmann, Gudrun Göhring, Fakhar H. Waqas, Frank Pessler, Ulrich Martin, Ruth Olmer
Publikováno v:
Stem Cell Research, Vol 69, Iss , Pp 103090- (2023)
The nuclear factor erythroid 2-related factor 2 (NFE2L2, known as NRF2) regulates the expression of antioxidative and anti-inflammatory proteins. In order to investigate its impact during viral infections and testing of antiviral compounds, we applie
Externí odkaz:
https://doaj.org/article/8e6814b4fbde47d2b87e5fb062e24452
Autor:
Ben O. Staar, Jan Hegermann, Bernd Auber, Raphael Ewen, Sandra von Hardenberg, Ruth Olmer, Isabell Pink, Jessica Rademacher, Martin Wetzke, Felix C. Ringshausen
Publikováno v:
Cells, Vol 12, Iss 22, p 2651 (2023)
Whole-exome sequencing has expedited the diagnostic work-up of primary ciliary dyskinesia (PCD), when used in addition to clinical phenotype and nasal nitric oxide. However, it reveals variants of uncertain significance (VUS) in established PCD genes
Externí odkaz:
https://doaj.org/article/72627d2f294f49dca41654b65cb5c128
Autor:
Denisa Bojkova, Philipp Reus, Leona Panosch, Marco Bechtel, Tamara Rothenburger, Joshua D. Kandler, Annika Pfeiffer, Julian U.G. Wagner, Mariana Shumliakivska, Stefanie Dimmeler, Ruth Olmer, Ulrich Martin, Florian W.R. Vondran, Tuna Toptan, Florian Rothweiler, Richard Zehner, Holger F. Rabenau, Karen L. Osman, Steven T. Pullan, Miles W. Carroll, Richard Stack, Sandra Ciesek, Mark N. Wass, Martin Michaelis, Jindrich Cinatl, Jr.
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105944- (2023)
Summary: Reliable, easy-to-handle phenotypic screening platforms are needed for the identification of anti-SARS-CoV-2 compounds. Here, we present caspase 3/7 activity as a readout for monitoring the replication of SARS-CoV-2 isolates from different v
Externí odkaz:
https://doaj.org/article/4a88cf04c85349bf88133734b02945c5
Autor:
Daniela Niemeyer, Saskia Stenzel, Talitha Veith, Simon Schroeder, Kirstin Friedmann, Friderike Weege, Jakob Trimpert, Julian Heinze, Anja Richter, Jenny Jansen, Jackson Emanuel, Julia Kazmierski, Fabian Pott, Lara M Jeworowski, Ruth Olmer, Mark-Christian Jaboreck, Beate Tenner, Jan Papies, Felix Walper, Marie L Schmidt, Nicolas Heinemann, Elisabeth Möncke-Buchner, Morris Baumgardt, Karen Hoffmann, Marek Widera, Tran Thi Nhu Thao, Anita Balázs, Jessica Schulze, Christin Mache, Terry C Jones, Markus Morkel, Sandra Ciesek, Leif G Hanitsch, Marcus A Mall, Andreas C Hocke, Volker Thiel, Klaus Osterrieder, Thorsten Wolff, Ulrich Martin, Victor M Corman, Marcel A Müller, Christine Goffinet, Christian Drosten
Publikováno v:
PLoS Biology, Vol 20, Iss 11, p e3001871 (2022)
Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible, infectious, and pathogenic than previous variants. Phenotypic properties of VOC rema
Externí odkaz:
https://doaj.org/article/f439c20a5aa647faba500c0b3fd9f88a
Autor:
Mark-Christian Jaboreck, Jonathan Lukas Lühmann, Mia Mielenz, Frauke Stanke, Gudrun Göhring, Ulrich Martin, Ruth Olmer, Sylvia Merkert
Publikováno v:
Stem Cell Research, Vol 64, Iss , Pp 102918- (2022)
The Transmembrane member 16A (TMEM16A), also known as anoctamin-1 (ANO1), is a calcium-activated chloride channel present in the airway epithelium. It is known to be involved in the apical chloride secretion indicating that TMEM16A could be addressed
Externí odkaz:
https://doaj.org/article/5b485fa104404f5ba6bd8e07af661d5f
Autor:
Marcus Lindner, Anna Laporte, Laura Elomaa, Cornelia Lee-Thedieck, Ruth Olmer, Marie Weinhart
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The relevance of cellular in vitro models highly depends on their ability to mimic the physiological environment of the respective tissue or cell niche. Static culture conditions are often unsuitable, especially for endothelial models, since they com
Externí odkaz:
https://doaj.org/article/bd22f8fe8e984409a1b12b850a7cd49f
Autor:
Felix Manstein, Kevin Ullmann, Christina Kropp, Caroline Halloin, Wiebke Triebert, Annika Franke, Clara‐Milena Farr, Anais Sahabian, Alexandra Haase, Yannik Breitkreuz, Michael Peitz, Oliver Brüstle, Stefan Kalies, Ulrich Martin, Ruth Olmer, Robert Zweigerdt
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 7, Pp 1063-1080 (2021)
Abstract To harness the full potential of human pluripotent stem cells (hPSCs) we combined instrumented stirred tank bioreactor (STBR) technology with the power of in silico process modeling to overcome substantial, hPSC‐specific hurdles toward the
Externí odkaz:
https://doaj.org/article/c7121fae9196446f87e88d0aaf778d3a
Autor:
Syed Fakhar‐ul‐Hassnain Waqas, Aaqib Sohail, Ariane Hai Ha Nguyen, Abdulai Usman, Tobias Ludwig, Andre Wegner, Muhammad Nasir Hayat Malik, Sven Schuchardt, Robert Geffers, Moritz Winterhoff, Sylvia Merkert, Ulrich Martin, Ruth Olmer, Nico Lachmann, Frank Pessler
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Background Congenital ISG15 deficiency is a rare autoinflammatory disorder that is driven by chronically elevated systemic interferon levels and predominantly affects central nervous system and skin. Methods and results We have developed ind
Externí odkaz:
https://doaj.org/article/8d6059a843714b79980249a16907b0fe
Autor:
Laura von Schledorn, David Puertollano Martín, Nicole Cleve, Janina Zöllner, Doris Roth, Ben Ole Staar, Jan Hegermann, Felix C. Ringshausen, Janna Nawroth, Ulrich Martin, Ruth Olmer
Publikováno v:
Cells, Vol 12, Iss 11, p 1467 (2023)
Primary ciliary dyskinesia (PCD) is a rare heterogenic genetic disorder associated with perturbed biogenesis or function of motile cilia. Motile cilia dysfunction results in diminished mucociliary clearance (MCC) of pathogens in the respiratory tract
Externí odkaz:
https://doaj.org/article/37b315f9676c482ab870e72e11a8cb41