Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ruth O. Payne"'
Autor:
Kazutoyo Miura, Ababacar Diouf, Michael P. Fay, Jordan R. Barrett, Ruth O. Payne, Ally I. Olotu, Angela M. Minassian, Sarah E. Silk, Simon J. Draper, Carole A. Long
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background For blood-stage malaria vaccine development, the in vitro growth inhibition assay (GIA) has been widely used to evaluate functionality of vaccine-induced antibodies (Ab), and Plasmodium falciparum reticulocyte-binding protein homo
Externí odkaz:
https://doaj.org/article/97da816f826f4510910320fa9d5e35e6
Autor:
Carolyn M. Nielsen, Jordan R. Barrett, Christine Davis, Jonathan K. Fallon, Cyndi Goh, Ashlin R. Michell, Catherine Griffin, Andrew Kwok, Carolin Loos, Samuel Darko, Farida Laboune, Mehmet Tekman, Ababacar Diouf, Kazutoyo Miura, Joseph R. Francica, Amy Ransier, Carole A. Long, Sarah E. Silk, Ruth O. Payne, Angela M. Minassian, Douglas A. Lauffenburger, Robert A. Seder, Daniel C. Douek, Galit Alter, Simon J. Draper
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Modifications to vaccine delivery that increase serum antibody longevity are of great interest for maximizing efficacy. We have previously shown that a delayed fractional (DFx) dosing schedule (0-1-6 month) — using AS01B-adjuvanted RH5.1 malaria an
Externí odkaz:
https://doaj.org/article/55c02c635c8641a881c121cc4f81a7fc
Autor:
Jo Salkeld, Yrene Themistocleous, Jordan R. Barrett, Celia H. Mitton, Thomas A. Rawlinson, Ruth O. Payne, Mimi M. Hou, Baktash Khozoee, Nick J. Edwards, Carolyn M. Nielsen, Diana Muñoz Sandoval, Florian A. Bach, Wiebke Nahrendorf, Raquel Lopez Ramon, Megan Baker, Fernando Ramos-Lopez, Pedro M. Folegatti, Doris Quinkert, Katherine J. Ellis, Ian D. Poulton, Alison M. Lawrie, Jee-Sun Cho, Fay L. Nugent, Philip J. Spence, Sarah E. Silk, Simon J. Draper, Angela M. Minassian
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In endemic settings it is known that natural malaria immunity is gradually acquired following repeated exposures. Here we sought to assess whether similar acquisition of blood-stage malaria immunity would occur following repeated parasite exposure by
Externí odkaz:
https://doaj.org/article/e073d6a50a334532bed97edf79803bd5
Autor:
Geneviève M. Labbé, Kazutoyo Miura, Sarah E. Silk, Wenjuan Gu, James E. Moon, Jing Jin, Ruth O. Payne, Michael P. Fay, Sheetij Dutta, Carole A. Long, Simon J. Draper
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019)
Abstract Background The ability to report vaccine-induced IgG responses in terms of µg/mL, as opposed arbitrary units (AU), enables a more informed interpretation of the magnitude of the immune response, and better comparison between vaccines target
Externí odkaz:
https://doaj.org/article/616891eb1b9a42dcaad67533514c0010
Autor:
Marija Zaric, Arianna Marini, Carolyn M. Nielsen, Gaurav Gupta, David Mekhaiel, Thao P. Pham, Sean C. Elias, Iona J. Taylor, Hans de Graaf, Ruth O. Payne, Yuanyuan Li, Sarah E. Silk, Chris Williams, Adrian V. S. Hill, Carole A. Long, Kazutoyo Miura, Sumi Biswas
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Plasmodium falciparum transmission-blocking vaccines (TBVs) targeting the Pfs25 antigen have shown promise in mice but the same efficacy has never been achieved in humans. We have previously published pre-clinical data related to a TBV candidate Pfs2
Externí odkaz:
https://doaj.org/article/f21e9455de774a698a42b7af607f559b
Autor:
Hans de Graaf, Ruth O. Payne, Iona Taylor, Kazutoyo Miura, Carol A. Long, Sean C. Elias, Marija Zaric, Angela M. Minassian, Sarah E. Silk, Lee Li, Ian D. Poulton, Megan Baker, Simon J. Draper, Diane Gbesemete, Nathan J. Brendish, Filipa Martins, Arianna Marini, David Mekhaiel, Nick J. Edwards, Rachel Roberts, Johan Vekemans, Sarah Moyle, Saul N. Faust, Eleanor Berrie, Alison M. Lawrie, Fergal Hill, Adrian V. S. Hill, Sumi Biswas
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundTransmission blocking vaccines targeting the sexual-stages of the malaria parasite could play a major role to achieve elimination and eradication of malaria. The Plasmodium falciparum Pfs25 protein (Pfs25) is the most clinically advanced ca
Externí odkaz:
https://doaj.org/article/daf9bdd8e4a1400a9c2b0c0584c0a152
Autor:
Sarah E. Silk, Wilmina F. Kalinga, Ivanny M. Mtaka, Nasoro S. Lilolime, Maximillian Mpina, Florence Milando, Saumu Ahmed, Ababacar Diouf, Fatuma Mkwepu, Beatus Simon, Thabit Athumani, Mohammed Rashid, Latipha Mohammed, Omary Lweno, Ali M. Ali, Gloria Nyaulingo, Bakari Mwalimu, Sarah Mswata, Tunu G. Mwamlima, Jordan R. Barrett, Lawrence T. Wang, Yrene Themistocleous, Lloyd D. W. King, Susanne H. Hodgson, Ruth O. Payne, Carolyn M. Nielsen, Alison M. Lawrie, Fay L. Nugent, Jee-Sun Cho, Carole A. Long, Kazutoyo Miura, Simon J. Draper, Angela M. Minassian, Ally I. Olotu
BackgroundRH5 is the leading blood-stage candidate antigen for inclusion in aPlasmodium falciparummalaria vaccine, however, its safety profile and ability to induce functional immune responses in a malaria-endemic population are unknown. Characterisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a74608ba837dc9e18097bb4d2468645f
https://doi.org/10.1101/2023.04.17.23288686
https://doi.org/10.1101/2023.04.17.23288686
Autor:
Holly Fernandez Lynch, Emily A. Largent, Thomas Smiley, Ruth O. Payne, Thomas C. Darton, Alvin E. Roth, Akilah Jefferson Shah, Ubaka Ogbogu, Jae Levy, Frank McCormick
Publikováno v:
The American Journal of Bioethics. 21:W8-W11
The peer commentaries on our Target Article, “Promoting Ethical Payment in Human Infection Challenge Studies,” (Fernandez Lynch et al. 2021) offer a number of insights that will help advance the co...
Autor:
C. Williams, David Mekhaiel, Yuanyuan Li, Adrian V. S. Hill, Carolyn M. Nielsen, Sarah E. Silk, Arianna Marini, Sean C. Elias, Hans de Graaf, Carole A. Long, Kazutoyo Miura, Ruth O. Payne, Iona J. Taylor, Marija Zaric, Gaurav Gupta, Sumi Biswas, Thao P. Pham
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Plasmodium falciparum transmission-blocking vaccines (TBVs) targeting the Pfs25 antigen have shown promise in mice but the same efficacy has never been achieved in humans. We have previously published pre-clinical data related to a TBV candidate Pfs2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c874d39d8d48838c597034f48464e5a5
https://eprints.soton.ac.uk/453259/
https://eprints.soton.ac.uk/453259/
Autor:
Sarah E. Silk, Arianna Marini, Iona J. Taylor, Saul N. Faust, Nathan J Brendish, Simon J. Draper, Adrian V. S. Hill, Sean C. Elias, Filipa Martins, Rachel Roberts, Hans de Graaf, Angela M. Minassian, Fergal Hill, Johan Vekemans, Marija Zaric, Eleanor Berrie, Sarah Moyle, Sumi Biswas, Nick J. Edwards, Carol A Long, Diane Gbesemete, David Mekhaiel, Alison M. Lawrie, Megan Baker, Lee Li, Ian D. Poulton, Ruth O. Payne, Kazutoyo Miura
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
BackgroundTransmission blocking vaccines targeting the sexual-stages of the malaria parasite could play a major role to achieve elimination and eradication of malaria. The Plasmodium falciparum Pfs25 protein (Pfs25) is the most clinically advanced ca