Real-World Treatment Patterns and Clinical Outcomes among Patients Receiving CDK4/6 Inhibitors for Metastatic Breast Cancer in a Canadian Setting Using AI-Extracted Data

Autor: Ruth Moulson, Guillaume Feugère, Tracy S. Moreira-Lucas, Florence Dequen, Jessica Weiss, Janet Smith, Christine Brezden-Masley

Publikováno v: Current Oncology, Vol 31, Iss 4, Pp 2172-2184 (2024)

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) are widely used in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2 negative (HER2−) advanced/metastatic breast cancer (ABC/MBC) in first line (1L), but little i

Externí odkaz: https://doaj.org/article/16198dbde7934a8f8964bc4ddb4c567e

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Autor: Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday

Publikováno v: Nature Cancer

The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc803a4ce48681e11987b33fd0a94af
https://doi.org/10.1038/s43018-022-00331-y

Building a Systematic Online Living Evidence Summary of COVID-19 Research

Autor: Broc Drury, Helen Fielding, Rita Bertani, Michael Sewell, Nimesh Jayasuriya, Ahmed Nazzal, Samantha Sives, Natasha Jayasuriya, Alex Clark, Robert Hillary, Mohammed Alawady, Alexander Christides, Isaac William Shaw, Sarah Gregory, Harry L Hébert, Fiona Kerr, Alexandra Bannach-Brown, Kirsten Miller, Kristiina Rannikmae, Juin W. Low, Ruth Moulson, Magnus Macleod, Fergal Waldron, Nathalie Percie du Sert, Torsten Rackoll, Stephanie L. Swift, Alison Harris, Nadia Soliman, Rebecca J. Hood, Rachel Blacow, Tiago Lubiana Alves, Catherine Sutherland, Sarah McCann, Karina Lôbo Hajdu, David E Henshall, Marianna Antonia Przybylska, Alexandria Chung, Santosh Shevade, Julija Baginskaite, Simran S Kapoor, Esther J Pearl, Brendan Gabriel, Martina Rudnicki, Mariam Fofana, Cigdem Selli, David Henry, Yoke Yue Chow, Thomas Ottavi, Kleber Neves, Katie Drax, Sarah Antar, Alice Carstairs, Anne Collins, Anthony Tsang, Joly Ghanawi, Ezgi Tanriver Ayder, Jing Liao, Can Ayder, Chris Sena, Zsanett Bahor, Malcolm Macleod, Gillian Currie, Emma Wilson, Emily S. Sena, Kaitlyn Hair

Publikováno v: 2021, ' Building a Systematic Online Living Evidence Summary of COVID-19 Research ', Journal of the European Association for Health Information and Libraries, vol. 17, no. 2 . https://doi.org/10.32384/jeahil17465

Throughout the global coronavirus pandemic, we have seen an unprecedented volume of COVID-19 researchpublications. This vast body of evidence continues to grow, making it difficult for research users to keep up with the pace of evolving research find

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69dcf15e89aaa0cc1d27a6f658c60388
https://www.pure.ed.ac.uk/ws/files/329808424/Building_a_Systematic_Online_Living_Evidence.pdf