Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ruth Madelaine Paredes"'
Autor:
Forest R. Sheppard, Antoni R. Macko, Jacob J. Glaser, Douglas K. Tadaki, Ruth Madelaine Paredes, Anthony E. Pusateri, Sylvain Cardin, Alexander J. Burdette, Philip J. Vernon, Craig A Koeller
Publikováno v:
Shock (Augusta, Ga.). 49(2)
Background We endeavored to develop clinically translatable nonhuman primate (NHP) models of severe polytraumatic hemorrhagic shock. Methods NHPs were randomized into five severe pressure-targeted hemorrhagic shock (PTHS) ± additional injuries scena
Autor:
Philip J. Vernon, Amanda J. Sooter, Leasha J. Schaub, Anthony E. Pusateri, Forest R. Sheppard, Jacob J. Glaser, Heather M. Grossman, Ruth Madelaine Paredes
Publikováno v:
Shock (Augusta, Ga.). 46(3 Suppl 1)
Neutrophilic inflammation is a mediator of morbidity and mortality in response to hemorrhagic shock. Although injury-induced neutrophil margination has long been observed, the nature of neutrophils' role in the "second hit" paradigm remains to be ful
Autor:
James K. Aden, Antoni R. Macko, Forest R. Sheppard, Alexander J. Burdette, Ruth Madelaine Paredes, Randy F. Crossland
Publikováno v:
Shock (Augusta, Ga.). 46(3 Suppl 1)
BACKGROUND Uncontrolled hemorrhage (UH), the leading cause of potentially survivable combat-related death, elicits a deleterious inflammatory response. Our group previously reported an increased secretion of pro-inflammatory cytokines in a novel non-
Publikováno v:
The Journal of Immunology. 196:194.9-194.9
Background Severe hemorrhage and trauma initiates an inflammatory cascade that promotes innate and adaptive immune-dysregulation. The kinetics of immune-cell subtype expansion, recruitment and retention, remain to be elucidated. We sought to immunoph
Publikováno v:
The Journal of Immunology. 196:51.21-51.21
Background Traumatic injury induces a significant inflammatory response. Post-injury responses of leukocyte subtypes, to include activation kinetics remain to be fully characterized to effectively direct therapeutic immunomodulation. We sought to det