Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ruth MacLeod"'
Autor:
Brian O. Smith, Amy J. Tibbo, William Fuller, George S. Baillie, Caglar Gök, Aisling McFall, Niall MacQuaide, Gonzalo S. Tejeda, Ruth MacLeod, Godfrey L. Smith, Connor M. Blair, Thomas Brand, Sara Dobi
Cyclic AMP is a ubiquitous second messenger used to transduce intracellular signals from a variety of Gs-coupled receptors. Compartmentalisation of protein intermediates within the cAMP signaling pathway underpins receptor-specific responses. The cAM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::662d72da79fdb83266d8ecdc28d28a77
https://doi.org/10.1101/2020.09.10.290825
https://doi.org/10.1101/2020.09.10.290825
Publikováno v:
The Journal of Biological Chemistry
zDHHC S-acyltransferases are enzymes catalyzing protein S-acylation, a common post-translational modification on proteins frequently affecting their membrane targeting and trafficking. The ankyrin repeat (AR) domain of zDHHC17 (HIP14) and zDHHC13 (HI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42928ab9d49b06302bd3d1c6144d0fd1
https://pubmed.ncbi.nlm.nih.gov/28882895
https://pubmed.ncbi.nlm.nih.gov/28882895
Autor:
Evelyne Manet, Vincent Maréchal, Dimitri Mompelat, George S. Baillie, Ruth MacLeod, Vincent Lotteau, Lionel Tafforeau, Quentin Bazot, Joanna B. Wilson, Derek M Leske, Henri Gruffat, Thibaut Deschamps
Publikováno v:
The Journal of general virology. 98(2)
The Epstein–Barr virus (EBV) nuclear antigen 1 (EBNA1) is a sequence-specific DNA-binding protein that plays an essential role in viral episome replication and segregation, by recruiting the cellular complex of DNA replication onto the origin (oriP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c2877ddae2de8aa924e599f9da9733
https://pubmed.ncbi.nlm.nih.gov/28284242
https://pubmed.ncbi.nlm.nih.gov/28284242
Autor:
Frank Christian, George S. Baillie, Ruth MacLeod, David R. Adams, Miles D. Houslay, Kirsty F. Houslay
Publikováno v:
Biochemical Journal
Houslay, K, Christian, F, MacLeod, R, Adams, D, Houslay, M D & Baillie, G S 2017, ' Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners ', Biochemical Journal, vol. 474, no. 4, pp. 597-609 . https://doi.org/10.1042/BCJ20160849
Houslay, K, Christian, F, MacLeod, R, Adams, D, Houslay, M D & Baillie, G S 2017, ' Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners ', Biochemical Journal, vol. 474, no. 4, pp. 597-609 . https://doi.org/10.1042/BCJ20160849
Cyclic AMP (cAMP)-specific phosphodiesterase-4 (PDE4) enzymes underpin compartmentalised cAMP signalling by localising to distinct signalling complexes. PDE4 long isoforms can be phosphorylated by mitogen-activated protein kinase-activated protein ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471b36512244c0b7b6f80a0058213440
https://eprints.gla.ac.uk/133060/7/133060.pdf
https://eprints.gla.ac.uk/133060/7/133060.pdf
OBJECTIVES: Although many traumatic incidents result in changes to appearance, little research has examined the experience of individuals distressed by such changes in connection with psychological processes involved in posttraumatic stress disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a84a490e03c4b8e4145039aa563df3
Autor:
Miles D. Houslay, Elaine V. Hill, Ruth MacLeod, Elaine Huston, Martin J. Lynch, Ahmed Mohamed, Daniel M. Collins, Eberhard Krause, George S. Baillie
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 105(35): 12791–12796
We identify a compartmentalized signaling system that identifies a functional role for the GTP exchange factor, exchange protein activated by cAMP (EPAC) coupled to Rap2 in the nucleus. In this system, cAMP regulates the nuclear/cytoplasmic trafficki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44718af4024f9463e7cc4e1e44ef332
https://doi.org/10.1073/pnas.0805167105
https://doi.org/10.1073/pnas.0805167105
Publikováno v:
Future Science OA
Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2932b35756f2a76f58f5944cef0aa2
https://doi.org/10.4155/fso.15.9
https://doi.org/10.4155/fso.15.9
Autor:
Brian Hendrich, Valerie Wilson, Keisuke Kaji, Ruth MacLeod, Jennifer Nichols, Isabel Caballero
Publikováno v:
Nature Cell Biology. 8:285-292
Cells of early mammalian embryos have the potential to develop into any adult cell type, and are thus said to be pluripotent. Pluripotency is lost during embryogenesis as cells commit to specific developmental pathways. Although restriction of develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2355f6b6521210a7e530199aeeb4af40
https://doi.org/10.1038/ncb1372
https://doi.org/10.1038/ncb1372
Autor:
Ruth MacLeod, Kim M. Brown, Miles D. Houslay, Helen V. Edwards, Noopur Advant, George S. Baillie, David R. Adams, Xiang Li, Nicola M. Devine, Allan J. Dunlop, Lucien C.D. Gibson
Publikováno v:
FEBS Letters. (20):3310-3316
βarrestins are molecular scaffolds that can bring together three-component mitogen-activated protein kinase signalling modules to promote signal compartmentalisation. We use peptide array technology to define novel interfaces between components with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f5a08fb2935e8f115f7a6eab433d04