Výsledky vyhledávání - "Ruth M. Stassart"

Akademický článek

Schwann cell functions in peripheral nerve development and repair

Autor: Mar Bosch-Queralt, Robert Fledrich, Ruth M. Stassart

Publikováno v: Neurobiology of Disease, Vol 176, Iss , Pp 105952- (2023)

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among the most multifaceted cells of the body. During development, SCs secure neuronal survival and participate in axonal path finding. Simultaneously, they orchestr

Externí odkaz: https://doaj.org/article/4c7b7e0271ba440bba729cf415087fbc

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Akademický článek

NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Onion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures.

Externí odkaz: https://doaj.org/article/d62e39531a3348db81bc0e371f8388cc

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Akademický článek

The Axon-Myelin Unit in Development and Degenerative Disease

Autor: Ruth M. Stassart, Wiebke Möbius, Klaus-Armin Nave, Julia M. Edgar

Publikováno v: Frontiers in Neuroscience, Vol 12 (2018)

Axons are electrically excitable, cable-like neuronal processes that relay information between neurons within the nervous system and between neurons and peripheral target tissues. In the central and peripheral nervous systems, most axons over a criti

Externí odkaz: https://doaj.org/article/36cee101f16f499598b7b22a430b063c

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Akademický článek

Publisher Correction: NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-2 (2019)

Michael W. Sereda was incorrectly associated with the Department of Cellular Neurophysiology, Hanover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany. The correct affiliations for Michael W. Sereda are Department of Neurogenetics, Max-Pla

Externí odkaz: https://doaj.org/article/97556eb535534b8791b4801491656226

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Akademický článek

The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration

Autor: Gerd Meyer zu Horste, Timo A. Miesbach, Johanna I. Muller, Robert Fledrich, Ruth M. Stassart, Bernd C. Kieseier, Michael P. Coleman, Michael W. Sereda

Publikováno v: Neurobiology of Disease, Vol 42, Iss 1, Pp 1-8 (2011)

Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy and a duplication of the peripheral myelin protein of 22 kDa (PMP22) gene causes the most frequent subform CMT1A. Clinical impairments are determined by the amount of axonal lo

Externí odkaz: https://doaj.org/article/deaaff98cb1a46f29740b2f3f9ce1367

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Akademický článek

Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases

Autor: Doris Krauter, Daniela Stausberg, Timon J Hartmann, Stefan Volkmann, Theresa Kungl, David A Rasche, Gesine Saher, Robert Fledrich, Ruth M Stassart, Klaus-Armin Nave, Sandra Goebbels, David Ewers, Michael W Sereda

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 3, Pp 616-640 (2024)

Abstract Haplo-insufficiency of the gene encoding the myelin protein PMP22 leads to focal myelin overgrowth in the peripheral nervous system and hereditary neuropathy with liability to pressure palsies (HNPP). Conversely, duplication of PMP22 causes

Externí odkaz: https://doaj.org/article/7fd4960236094ab48972800c5f7528ba

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