Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ruth M. Escalona"'
Autor:
Ruth M. Escalona, Simon Chu, Elif Kadife, Jason K. Kelly, George Kannourakis, Jock K. Findlay, Nuzhat Ahmed
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-27 (2022)
Abstract Background The endogenous tissue inhibitor of metalloproteinase-2 (TIMP-2), through its homeostatic action on certain metalloproteinases, plays a vital role in remodelling extracellular matrix (ECM) to facilitate cancer progression. This stu
Externí odkaz:
https://doaj.org/article/bf8b668de7d74546917e2a322c13f1ee
Autor:
Ruth M. Escalona, Maree Bilandzic, Patrick Western, Elif Kadife, George Kannourakis, Jock K. Findlay, Nuzhat Ahmed
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-24 (2020)
Abstract Background The metzincin family of metalloproteinases and the tissue inhibitors of metalloproteinases (TIMPs) are essential proteins required for biological processes during cancer progression. This study aimed to determine the role of TIMP-
Externí odkaz:
https://doaj.org/article/9fe838f0122f44d1adf4cc3f3d65be75
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
BackgroundThe tissue inhibitors of metalloproteinase (TIMPs) and their associated metalloproteinase (MMPs) are essential regulators of tissue homeostasis and are essential for cancer progression. This study analyzed the expression of TIMP-1,-2,-3 and
Externí odkaz:
https://doaj.org/article/a9baf486fd6b441a82151bf3f2621676
Autor:
Revati Sharma, Showan Balta, Ali Raza, Ruth M. Escalona, George Kannourakis, Prashanth Prithviraj, Nuzhat Ahmed
Publikováno v:
Cancers; Volume 15; Issue 9; Pages: 2586
The process of epithelial-mesenchymal transition (EMT) involves the phenotypic transformation of cells from epithelial to mesenchymal status. The cells exhibiting EMT contain features of cancer stem cells (CSC), and the dual processes are responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c65d24f060eb6674c8d1d37316f4d00
https://doi.org/10.3390/cancers15092586
https://doi.org/10.3390/cancers15092586
Autor:
Maree Bilandzic, Ruth M. Escalona, Patrick S Western, George Kannourakis, Nuzhat Ahmed, Elif Kadife, Jock K. Findlay
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-24 (2020)
BMC Cancer
BMC Cancer
Background The metzincin family of metalloproteinases and the tissue inhibitors of metalloproteinases (TIMPs) are essential proteins required for biological processes during cancer progression. This study aimed to determine the role of TIMP-2 in ovar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c17686a9e0aa98c2134e934f09863f
http://link.springer.com/article/10.1186/s12885-020-07274-6
http://link.springer.com/article/10.1186/s12885-020-07274-6
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2022)
Frontiers in Oncology, Vol 11 (2022)
BackgroundThe tissue inhibitors of metalloproteinase (TIMPs) and their associated metalloproteinase (MMPs) are essential regulators of tissue homeostasis and are essential for cancer progression. This study analyzed the expression of TIMP-1,-2,-3 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83010f8596ced4741033dbf1847aac4a
https://pubmed.ncbi.nlm.nih.gov/35047406
https://pubmed.ncbi.nlm.nih.gov/35047406
Autor:
Celesta Fong, Nuzhat Ahmed, Julian Ratcliffe, Nhiem Tran, Ruth M. Escalona, Calum J. Drummond, Fiona H. Tan, Jiali Zhai, Rodney B. Luwor, Judith A. Scoble
Publikováno v:
ACS applied materialsinterfaces. 10(30)
Chemotherapy using cytotoxic agents, such as paclitaxel (PTX), is one of the most effective treatments for advanced ovarian cancer. However, due to nonspecific targeting of the drug and the presence of toxic solvents required for dissolving PTX prior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b916de0322a75d1075d12fee988b2bc
https://pubmed.ncbi.nlm.nih.gov/29963859
https://pubmed.ncbi.nlm.nih.gov/29963859
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 2, p 450 (2018)
International Journal of Molecular Sciences, Vol 19, Iss 2, p 450 (2018)
Approximately sixty per cent of ovarian cancer patients die within the first five years of diagnosis due to recurrence associated with chemoresistance. The metzincin family of metalloproteinases is enzymes involved in matrix remodeling in response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349924a2f48e52233970fcc740f4d991
https://pubmed.ncbi.nlm.nih.gov/29393911
https://pubmed.ncbi.nlm.nih.gov/29393911
Publikováno v:
Clinical Cancer Research. 25:AP26-AP26
PURPOSE: The treatment of ovarian cancer (OC) with chemotherapy leaves resistant cancer cells which in a short time re-grow as recurrent cancer. A diverse array of resistance mechanisms for chemotherapy has been described but none have proven as viab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6373f06bd2b1d7963fdb26e309a9d7c8
https://doi.org/10.1158/1557-3265.ovcasymp18-ap26
https://doi.org/10.1158/1557-3265.ovcasymp18-ap26
Autor:
Chantel Samardzija, Maree Bilandzic, Ruth M. Escalona, George Kannourakis, Nuzhat Ahmed, Rodney B. Luwor, Jock K. Findlay, Maoshan Chen, David W. Greening
Publikováno v:
Scientific Reports
Oct4A is a master regulator of self-renewal and pluripotency in embryonic stem cells. It is a well-established marker for cancer stem cell (CSC) in malignancies. Recently, using a loss of function studies, we have demonstrated key roles for Oct4A in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650bad49e3b458c295138693fe08af8c
https://pubmed.ncbi.nlm.nih.gov/28406185
https://pubmed.ncbi.nlm.nih.gov/28406185