Výsledky vyhledávání - "Ruth M. Connaughton"

Akademický článek

Mechanisms of obesity induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies

Autor: Maeve A McArdle, Orla M Finucane, Ruth M Connaughton, Aoibheann M McMorrow, Helen M Roche

Publikováno v: Frontiers in Endocrinology, Vol 4 (2013)

Obesity and associated chronic inflammation initiate a state of insulin resistance. The secretion of chemoattractants such as MCP-1 and MIF and of cytokines IL-6, TNF-α and IL-1β, draw immune cells including dendritic cells, T cells and macrophages

Externí odkaz: https://doaj.org/article/ddf1d8c7997640c6929231450b6c73ef

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Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome

Autor: Aoife A. Cooke, Helen M. Roche, Claire L. Lyons, Ruth M. Connaughton, Aoibheann M McMorrow

Publikováno v: European Journal of Pharmacology. 785:207-214

The metabolic syndrome is a group of obesity associated metabolic conditions that result in increased risk of cardiovascular disease and type 2 diabetes. Global increases in obesity rates have led to an increase in metabolic syndrome resulting in a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0d49875914fd7f6e1c3f5234c51e33
https://doi.org/10.1016/j.ejphar.2016.04.021

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Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood

Autor: Helen M. Roche, Aoibheann M McMorrow, Ruth M. Connaughton, Fiona E Lithander, Fiona C. McGillicuddy

Publikováno v: Connaughton, R M, McMorrow, A M, McGillicuddy, F C, Lithander, F E & Roche, H M 2016, ' Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood ', Proceedings of the Nutrition Society, vol. 75, no. 2, pp. 115-24 . https://doi.org/10.1017/S0029665116000070

Obesity-related metabolic conditions such as insulin resistance (IR), type 2 diabetes and CVD share a number of pathological features, one of which is metabolic-inflammation. Metabolic-inflammation results from the infiltration of immune cells into t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91922b2eb9efa82e2b413f2d3573529
https://doi.org/10.1017/s0029665116000070

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Personalized Cardio‐Metabolic Responses to an Anti‐Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial

Autor: Aoibheann M McMorrow, Helen M. Roche, Melissa J. Morine, Davi D. Cheishvili, Tiago R. Magalhaes, Ruth M. Connaughton, Sean Ennis, Fiona E Lithander, Edna Roche, Fiona C. McGillicuddy, Moshe Szyf, Richard E. Tremblay, Marie Louise Healy, Maria Hughes

Publikováno v: Molecular Nutrition & Food Research
McMorrow, A M, Connaughton, R M, Magalhães, T R, McGillicuddy, F C, Hughes, M F, Cheishvili, D D, Morine, M J, Ennis, S, Healy, M L, Roche, E F, Tremblay, R E, Szyf, M, Lithander, F E & Roche, H M 2018, ' Personalized Cardio-Metabolic Responses to an Anti-Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial ' Molecular Nutrition and Food Research, vol. 62, no. 10, 1701008 . DOI: 10.1002/mnfr.201701008

Scope: Chronic inflammation and hypoadiponectinemia are characteristics of obesity-induced insulin resistance (IR). The effect of an anti-inflammatory nutrition supplement (AINS) on IR and adiponectin biology in overweight adolescents was investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864da7322a5925b24ad7cd6ff0b7b2e4
http://europepmc.org/articles/PMC6079645

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Weighted Gene Co-Expression Network Analysis Identifies Gender Specific Modules and Hub Genes Related to Metabolism and Inflammation in Response to an Acute Lipid Challenge

Autor: Peadar O'Gaora, Attia Fatima, Colm M. O'Grada, Miriam F. Ryan, Aoife M. Murphy, Lorraine Brennan, Ruth M. Connaughton, Anna Weiser, Helen M. Roche

Publikováno v: Molecular nutritionfood research. 62(2)

cope : Inflammation is characteristic of diet-related diseases including obesity and type 2 diabetes (T2D). However, biomarkers of inflammation that reflect the early stage metabolic derangements are not optimally sensitive. Lipid challenges elicit p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67be6084ea0750f653d42d5d1adab610
https://pubmed.ncbi.nlm.nih.gov/28952191

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Weight status and dietary fat modulate high density lipoprotein particle function in adolescents: results from a cross-sectional analysis and a randomised, placebo-controlled, crossover trial

Autor: E. Carolan, Fiona C. McGillicuddy, Ruth M. Connaughton, Aoibheann M McMorrow, Helen M. Roche, Fiona E Lithander, D. O'Shea, M. O'Reilly

Publikováno v: Proceedings of the Nutrition Society. 75

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70509d6ef35f08d495f2118d845f9daf
https://doi.org/10.1017/s0029665116000859

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Combination of Anti‐Inflammatory Nutrients shows Synergistic Potential at Modulating Pro‐Inflammatory Cytokines in an In Vitro S etting

Autor: Ruth M. Connaughton, Fiona E Lithander, Fiona C. McGillicuddy, Aoibheann M McMorrow, Helen M. Roche, Anna M. Kirwan

Publikováno v: The FASEB Journal. 29

LC n-3 PUFAs, vitamin C and EGCG display anti-inflammatory properties. Studies looking at these nutrients individually have shown mixed results. A combination of anti-inflammatory nutrients may be more beneficial at modulating inflammation. We hypoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c47cf7d87690c8e3dcbc3bb9a2f8d084
https://doi.org/10.1096/fasebj.29.1_supplement.lb234

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Anti‐Inflammatory Dietary Intervention Selectively Improves Insulin Sensitivity in Metabolically Unhealthy Overweight Adolescents

Autor: Fiona C. McGillicuddy, Edna Roche, Ruth M. Connaughton, Fiona E Lithander, Helen M. Roche, M. L. Healy, Aoibheann M McMorrow

Publikováno v: The FASEB Journal. 29

Anti-inflammatory nutritional approaches may attenuate obesity-induced insulin resistance; however results from clinical studies are inconsistent. Baseline metabotype may partially discriminate responders from non-responders. This 8-wk randomized, pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72ccedd85bbc9db1258b0d64fdbe7e76
https://doi.org/10.1096/fasebj.29.1_supplement.lb233

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Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality

Autor: Ruth M. Connaughton, Fiona E Lithander, Aoibheann M McMorrow, Helen M. Roche

Publikováno v: The Proceedings of the Nutrition Society. 74(1)

Evidence suggests that at a population level, childhood and adolescent obesity increase the long-term risk of chronic diseases such as type 2 diabetes and CVD. At an individual level, however, the metabolic consequences of obesity in youth vary immen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f348172065ff7bcc149c4ce8e66b1c1
https://pubmed.ncbi.nlm.nih.gov/25497038

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Mechanisms of Obesity-Induced Inflammation and Insulin Resistance: Insights into the Emerging Role of Nutritional Strategies

Autor: Ruth M. Connaughton, Aoibheann M McMorrow, Maeve A. McArdle, Orla M. Finucane, Helen M. Roche

Publikováno v: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 4 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d3663eea022de43fef05b66891669f

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