Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ruth M, Densham"'
Autor:
Hannah L. Mackay, Helen R. Stone, George E. Ronson, Katherine Ellis, Alexander Lanz, Yara Aghabi, Alexandra K. Walker, Katarzyna Starowicz, Alexander J. Garvin, Patrick Van Eijk, Stefan A. Koestler, Elizabeth J. Anthony, Ann Liza Piberger, Anoop S. Chauhan, Poppy Conway-Thomas, Alina Vaitsiankova, Sobana Vijayendran, James F. Beesley, Eva Petermann, Eric J. Brown, Ruth M. Densham, Simon H. Reed, Felix Dobbs, Marco Saponaro, Joanna R. Morris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mammalian DNA replication relies on various DNA helicase and nuclease activities to ensure accurate genetic duplication, but how different helicase and nuclease activities are properly directed remains unclear. Here, we identify the ubiquiti
Externí odkaz:
https://doaj.org/article/28ce5cbc0af0403c82bcaf2f474d55ce
Autor:
Michael Uckelmann, Ruth M. Densham, Roy Baas, Herrie H. K. Winterwerp, Alexander Fish, Titia K. Sixma, Joanna R. Morris
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
BRCA1 ligase activity is tightly regulated to maintain genome stability and confer DNA double strand repair. Here the authors identify USP48 as a H2A deubiquitinating enzyme that acts as a BRCA1 E3 ligase antagonist and characterize its role during D
Externí odkaz:
https://doaj.org/article/1e3a338b35724ff5b4dbc88530cac69f
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 6 (2019)
The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protectio
Externí odkaz:
https://doaj.org/article/31d9862afa524d30842570daf124c4d2
Autor:
Ruth M. Densham, Joanna R. Morris
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
DNA double-strand breaks (DSBs) occur in our cells in the context of chromatin. This type of lesion is toxic, entirely preventing genome continuity and causing cell death or terminal arrest. Several repair mechanisms can act on DNA surrounding a DSB,
Externí odkaz:
https://doaj.org/article/c475ab46b36b4bc1a6a96ca666fe6c0c
The small ubiquitin-like modifier (SUMO) family is composed of five members, SUMO1, the highly similar SUMO2/SUMO3, SUMO4 and the tissue-specific SUMO5 (SUMO1P1). Sequence variation in SUMO4 is thought to prevent its maturation, resulting in an un-co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c26234eb489f908f477fb63e6dc49bb
https://doi.org/10.1101/2022.03.23.485504
https://doi.org/10.1101/2022.03.23.485504
Autor:
James F.J. Beesley, Manuel Daza-Martin, Grant S. Stewart, Alexander J Garvin, Thomas J. McCorvie, Helen R Stone, Mohammed Jamshad, Hannah L. Mackay, Jennifer L. Coles, Anoop Singh Chauhan, Katarzyna Starowicz, Xiaodong Zhang, George E. Ronson, Stephanie Tye, Ruth M Densham, Alexandra K. Walker, Joanna R. Morris
Publikováno v:
Nature. 571:521-527
The integrity of genomes is constantly threatened by problems encountered by the replication fork. BRCA1, BRCA2 and a subset of Fanconi anaemia proteins protect stalled replication forks from degradation by nucleases, through pathways that involve RA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb6e7408ed0154a6866ac4d69985a08
https://doi.org/10.1038/s41586-019-1363-4
https://doi.org/10.1038/s41586-019-1363-4
Autor:
George E. Ronson, Anoop Singh Chauhan, Alexander J Garvin, Alexandra K. Walker, Hannah L. Mackay, Mohammed Jamshad, Helen R Stone, James F.J. Beesley, Manuel Daza-Martin, Joanna R. Morris, Ruth M Densham, Katarzyna Starowicz, Alexander J. Lanz
Publikováno v:
Genes & Development. 33:333-347
SUMOylation (small ubiquitin-like modifier) in the DNA double-strand break (DSB) response regulates recruitment, activity, and clearance of repair factors. However, our understanding of a role for deSUMOylation in this process is limited. Here we ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110005d32c9995cf1161181521915147
https://doi.org/10.1101/gad.321125.118
https://doi.org/10.1101/gad.321125.118
Autor:
Manuel Daza-Martin, Joanna R. Morris, Mohammed Jamshad, Helen R Stone, Katarzyna Starowicz, Alexander J Garvin, Ruth M Densham, Anoop Singh Chauhan, Alexandra K. Walker, Hannah L. Mackay
SUMOylation in the DNA double-strand break (DSB) response regulates recruitment, activity and clearance of repair factors. However, our understanding of a role for deSUMOylation in this process is limited. Here we identify different mechanistic roles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03b582a287d45a580859fef829795e5
Autor:
Joanna R. Morris, Anoop Singh Chauhan, Grant S. Stewart, James F.J. Beesley, Ruth M Densham, Mohammed Jamshad, Manuel Daza-Martin, Jennifer L. Coles, Katarzyna Starowicz
BRCA1, BRCA2 and a subset of Fanconi’s Anaemia proteins act to promote RAD51-mediated protection of newly synthesised DNA at stalled replication forks from degradation by nucleases. How BRCA1 contributes, how it is regulated and whether replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403ac79cf87d0619e8ad0d1282a4c710
https://doi.org/10.1101/478511
https://doi.org/10.1101/478511
Autor:
Ruth M. Densham
Publikováno v:
DNA Repair and Replication ISBN: 9780429464744
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90e9396128c113cf32fab91fdbd6642f
https://doi.org/10.1201/9780429464744-9
https://doi.org/10.1201/9780429464744-9