Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ruth Lock"'
Autor:
Chunlin Chen, Liming Zhang, Cristina Almansa, Maria Rosario, Michael Cwik, Suresh K. Balani, Ruth Lock
Publikováno v:
Clinical Pharmacology in Drug Development. 11:142-149
Autor:
Richard Czerniak, Blanka Cieslarová, Viera Kupčová, Maria Rosario, Ruth Lock, Cheng Dong, George Dukes
Publikováno v:
Journal of clinical pharmacology. 62(8)
Felcisetrag (formerly known as TAK-954) is a selective serotonin receptor agonist under investigation for use in patients with postoperative gastrointestinal dysfunction. The safety, tolerability, and pharmacokinetics (PK) of intravenous (i.v.) felci
Autor:
Chunlin, Chen, Liming, Zhang, Cristina, Almansa, Maria, Rosario, Michael, Cwik, Suresh K, Balani, Ruth, Lock
Publikováno v:
Clinical pharmacology in drug developmentReferences. 11(2)
The 5-hydroxytryptamine type-4 receptor agonist felcisetrag (TAK-954) is being investigated for improving gastrointestinal motility in postoperative gastrointestinal dysfunction. Polypharmacy often occurs in this setting, and as in vitro data indicat
Autor:
H Watson, Rosemary Sugar, Steve Collingwood, Nichola Smith, S Czarnecki, A. Schumacher, Ruth Lock, B Ethell, Chris Poll, Alice Young, Martin Gosling, Derek Paisley, J. Harris, T Faller, Kevin Coote, Gareth Williams, Urs Baettig, Morris Tweed, Henry Danahay, M Vyas, Juan R. Sabater, Paul J. Groot-Kormelink, William M. Abraham
Publikováno v:
British Journal of Pharmacology. 172:2814-2826
Background and Purpose Inhaled amiloride, a blocker of the epithelial sodium channel (ENaC), enhances mucociliary clearance (MCC) in cystic fibrosis (CF) patients. However, the dose of amiloride is limited by the mechanism-based side effect of hyperk
Autor:
Ruth Lock, Steven M. Rowe, Henry Danahay, Ping Zhou, Heather Hathorne, Ginger Reeves, John P. Clancy, Smita Abbi, G. Martin Solomon, David A. Waltz, Didier Renard
Prostasin, a trypsin-like serine protease, is a channel-activating protease and major regulator of epithelial sodium channel-mediated sodium absorption. Its direct inhibition by camostat represents a potential approach to inhibiting sodium transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9665de76237ecba775f13c0ffec7c9d3
https://europepmc.org/articles/PMC3707174/
https://europepmc.org/articles/PMC3707174/
Autor:
Lea Ann Dailey, Colin J. Hardy, Per Gerde, Ben Forbes, Graham Somers, Douglas Ferguson, Tim McGovern, Gary R. Pitcairn, Ron K. Wolff, David G. Hassall, Ruth Lock, Rhys M. Jones, Janet Maas, Bahman Asgharian, Lena Gustavsson, Mark Gumbleton
Publikováno v:
Advanced drug delivery reviews. 63(1-2)
Dosimetry, safety and the efficacy of drugs in the lungs are critical factors in the development of inhaled medicines. This article considers the challenges in each of these areas with reference to current industry practices for developing inhaled pr