Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ruth L. Saxl"'
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-8 (2024)
Abstract Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) family of cytokines and has been found to have anti-inflammatory and pro-inflammatory properties in various cellular and disease contexts. OSM signals through two receptor complexes,
Externí odkaz:
https://doaj.org/article/33b153597f8f4cf5ae819de4e310aeb3
Autor:
Julie Wells, Anuj Srivastava, Richard S. Maser, Rupesh Kesharwani, Vishal Kumar Sarsani, Sandra L. Daigle, Ryan P. Lynch, Heidi J. Munger, Rosalinda Doty, Ruth L. Saxl, Carol J. Bult
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of gene expression in species ranging from plants to mammals. Unraveling the complex networks of miRNA-mediated regulation of gene expression requires the ability to identify the mRNA tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86962b6992e17ec70699f82a2d887854
https://doi.org/10.1101/2022.08.22.504764
https://doi.org/10.1101/2022.08.22.504764
Autor:
Beth L Dumont, Jane Branca, Rosalinda A Doty, Benjamin E. Low, Michael V Wiles, Muneer G. Hasham, Ruth L Saxl, Jennifer K Sargent
Publikováno v:
Genes & Cancer
Known as the guardian of the genome, transformation-related protein 53 (TRP53) is a well -known tumor suppressor. Here, we describe a novel TRP53 deficient mouse model on a tumor prone background—SJL/J mice. The absence of TRP53 (TRP53 nullizygosit
Autor:
Christopher L Baker, Shimpei Kajita, Michael Walker, Ruth L Saxl, Narayanan Raghupathy, Kwangbom Choi, Petko M Petkov, Kenneth Paigen
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004916 (2015)
Meiotic recombination generates new genetic variation and assures the proper segregation of chromosomes in gametes. PRDM9, a zinc finger protein with histone methyltransferase activity, initiates meiotic recombination by binding DNA at recombination
Externí odkaz:
https://doaj.org/article/d4d1b01aa2a9472d9ac04e117482306d
Autor:
Ruth L. Saxl, Fengyun Sun, Petko M. Petkov, Yasuhiro Fujiwara, Jianjun Hu, Kenneth Paigen, Mary Ann Handel, Christopher L. Baker, Laura G. Reinholdt
Publikováno v:
Chromosoma. 124:397-415
Developmental progress of germ cells through meiotic phases is closely tied to ongoing meiotic recombination. In mammals, recombination preferentially occurs in genomic regions known as hotspots; the protein that activates these hotspots is PRDM9, co
Autor:
Emil D. Parvanov, Hui Tian, Timothy Billings, Ruth L. Saxl, Catrina Spruce, Rakesh Aithal, Lumir Krejci, Kenneth Paigen, Petko M. Petkov
In mammals, meiotic recombination occurs at 1-2 kb genomic regions termed hotspots, whose positions and activities are determined by PRDM9, a DNA-binding histone methyltransferase. We now show that the KRAB domain of PRDM9 forms complexes with additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52a25c5705f7be5bfb124213aca6244
Autor:
Gladys F. Maley, Charles R. Hauer, Robert MacColl, Frank Maley, Li-Ming Changchien, Ruth L. Saxl
Publikováno v:
Protein Science. 16:1439-1448
Wild-type thymidylate synthase (WT-TS) from Escherichia coli and several of its mutants showed varying degrees of susceptibility to trypsin. While WT-TS was resistant to trypsin as were the mutants C146S, K48E, and R126K, others such as Y94A, Y94F, C
Autor:
Michael G. Walker, Kenneth Paigen, Timothy Billings, Hui Tian, Ruth L. Saxl, Matthew A. Hibbs, Mary Ann Handel, Natalie R. Powers, Kwangbom Choi, Petko M. Petkov, Christopher L. Baker, Gregory W. Carter
Publikováno v:
Epigenetics & Chromatin
Background Genetic recombination plays an important role in evolution, facilitating the creation of new, favorable combinations of alleles and the removal of deleterious mutations by unlinking them from surrounding sequences. In most mammals, the pla
Publikováno v:
Biochemistry. 43:9177-9184
In this paper we present a new and possibly more effective way of inhibiting thymidylate synthase (TS) in cells than through the use of substrate analogue inhibitors. An inactive double mutant of TS (DM), Arg 1 2 6 Glu/Cys 1 4 6 Trp, is shown to prog
Publikováno v:
Biochemistry. 42:4544-4551
Evidence is presented that 5-imidazolylpropynyl-2'-deoxyuridine 5'-monophosphate (IP-dUMP) is a mechanism-based, irreversible inactivator of Escherichia coli thymidylate synthase (TS), which covalently modifies Tyr94 at the active site of the enzyme.