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pro vyhledávání: '"Ruth Knox"'
Autor:
Ruth Knox, Emily Kempa, Reynard Spiess, Christian Schnepel, Sabine Flitsch, Perdita Barran, Nicholas Turner
Ambient ionization coupled to mass spectrometry has the advantages of minimal requirements for sample preparation prior to analysis which renders it suitable for high throughput screening. We present a protocol that permits the application of this me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48a653e49f4b14f692c8695cc4cc6098
https://doi.org/10.26434/chemrxiv-2022-5mk8z
https://doi.org/10.26434/chemrxiv-2022-5mk8z
Publikováno v:
Ion Mobility-Mass Spectrometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ddc846c2da8922f4269c8f0163a04c4
https://doi.org/10.1039/9781839162886-00402
https://doi.org/10.1039/9781839162886-00402
Publikováno v:
Journal of Molecular Biology. 430:3311-3322
Conformational dynamics are increasingly recognized as being essential for enzyme function. However, there is virtually no direct experimental evidence to support the notion that individual dynamic modes are required for specific catalytic processes,
Publikováno v:
Journal of visualized experiments : JoVE. (122)
Intrinsically disordered proteins (IDPs) have long been a challenge to structural biologists due to their lack of stable secondary structure elements. Hydrogen-Deuterium Exchange (HDX) measured at rapid time scales is uniquely suited to detect struct