Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment.

Autor: Brian C VanderVen, Ruth J Fahey, Wonsik Lee, Yancheng Liu, Robert B Abramovitch, Christine Memmott, Adam M Crowe, Lindsay D Eltis, Emanuele Perola, David D Deininger, Tiansheng Wang, Christopher P Locher, David G Russell

Publikováno v: PLoS Pathogens, Vol 11, Iss 2, p e1004679 (2015)

Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to support growth in macrophages. By conducting an extensive, unbiased chemical screen to identify small molecules that inhibit Mtb metabolism within macrophages, we i

Externí odkaz: https://doaj.org/article/6109150c12bc4f40969bd55a5cb7ecca

Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

Autor: David D. Deininger, Wonsik Lee, Ruth J. Fahey, David G. Russell, Tiansheng Wang, Lindsay D. Eltis, Adam M. Crowe, Christine Memmott, Brian C. VanderVen, Emanuele Perola, Robert B. Abramovitch, Christopher Locher, Yancheng Liu

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 11, Iss 2, p e1004679 (2015)

Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to support growth in macrophages. By conducting an extensive, unbiased chemical screen to identify small molecules that inhibit Mtb metabolism within macrophages, we i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0bcf27fb291685e6ff7d91deccb5ab
http://europepmc.org/articles/PMC4335503

Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress

Autor: Brian C. VanderVen, Wonsik Lee, Ruth J. Fahey, David G. Russell

Publikováno v: The Journal of biological chemistry. 288(10)

Recent data indicate that the nutrients available to Mycobacterium tuberculosis (Mtb) inside its host cell are restricted in their diversity. Fatty acids and cholesterol appear more favored; however, their degradation can result in certain metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9510b69acd0c2e2a786173975236f40
https://pubmed.ncbi.nlm.nih.gov/23306194

The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions

Autor: M. Blanco, José A. Vázquez-Boland, Alain Ocampo, Michal Letek, Inna Cherevach, Tom C. Freeman, Jolyon Holdstock, Desmond P Leadon, John F. Prescott, Mandy Sanders, Tom Buckley, Ruth J. Fahey, Mariela Scortti, Michael A. Quail, Ursula Fogarty, Ana Valero-Rello, Jesús Navas, Héctor Rodríguez, Wim G. Meijer, Patricia González, Julian Parkhill, Stephen D. Bentley, Alexia Hapeshi, Iain MacArthur

Publikováno v: PLoS Genetics. 2010 Sep 30;6(9). pii: e1001145
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
PLoS Genetics
PLOS GENETICS
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Letek, M, Gonzalez, P, MacArthur, I, Rodriguez, H, Freeman, T C, Valero Rello, A, Blanco, M, Buckley, T, Cherevach, I, Fahey, R, Hapeshi, A, Holdstock, J, Leadon, D, Navas, J, Ocampo, A, Quail, M A, Sanders, M, Scortti, M M, Prescott, J F, Fogarty, U, Meijer, W G, Parkhill, J, Bentley, S D & Vazquez-Boland, J A 2010, ' The Genome of a Pathogenic Rhodococcus: Cooptive Virulence Underpinned by Key Gene Acquisitions ', PLoS Genetics, vol. 6, no. 9, e1001145, pp.-. https://doi.org/10.1371/journal.pgen.1001145
PLoS Genetics, 2010, 6(9), e1001145
PLoS Genetics, Vol 6, Iss 9, p e1001145 (2010)

We report the genome of the facultative intracellular parasite Rhodococcus equi, the only animal pathogen within the biotechnologically important actinobacterial genus Rhodococcus. The 5.0-Mb R. equi 103S genome is significantly smaller than those of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac62492e5697cd5c6b4a9dcd77c0dd67
http://hdl.handle.net/10902/1536