Zobrazeno 1 - 10
of 315
pro vyhledávání: '"Ruth J, Muschel"'
Autor:
Ceren Yalaz, Esther Bridges, Nasullah K. Alham, Christos E. Zois, Jianzhou Chen, Karim Bensaad, Ana Miar, Elisabete Pires, Ruth J. Muschel, James S. O. McCullagh, Adrian L. Harris
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-26 (2024)
Abstract Background PDE6H encodes PDE6γ′, the inhibitory subunit of the cGMP-specific phosphodiesterase 6 in cone photoreceptors. Inhibition of PDE6, which has been widely studied for its role in light transduction, increases cGMP levels. The purp
Externí odkaz:
https://doaj.org/article/a0980800c2ff4d25880a8bc551833cad
Autor:
Jakub Köry, Vedang Narain, Bernadette J Stolz, Jakob Kaeppler, Bostjan Markelc, Ruth J Muschel, Philip K Maini, Joe M Pitt-Francis, Helen M Byrne
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011252 (2024)
Tumour angiogenesis leads to the formation of blood vessels that are structurally and spatially heterogeneous. Poor blood perfusion, in conjunction with increased hypoxia and oxygen heterogeneity, impairs a tumour's response to radiotherapy. The opti
Externí odkaz:
https://doaj.org/article/bc036081c6b94ada82eb532b05c135a7
Autor:
Jae Hong Im, Jon N. Buzzelli, Keaton Jones, Fanny Franchini, Alex Gordon-Weeks, Bostjan Markelc, Jianzhou Chen, Jin Kim, Yunhong Cao, Ruth J. Muschel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Macrophages contribute to tumour progression and response to therapy. Here, the authors show that absence of FGF2 in the tumour microenvironment reduces tumour growth and enhances the anti-tumour immune response by altering macrophage polarization. A
Externí odkaz:
https://doaj.org/article/aac2c94a42384be185bf6c4fce5f6dff
Autor:
Serena Lucotti, Ruth J. Muschel
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
During the process of hematogenous metastasis, tumor cells interact with platelets and their precursors megakaryocytes, providing a selection driver for the metastatic phenotype. Cancer cells have evolved a plethora of mechanisms to engage platelet a
Externí odkaz:
https://doaj.org/article/96dc66604db14da88820f8402b0d98e6
Autor:
Jenny A. F. Vermeer, Jonathan Ient, Bostjan Markelc, Jakob Kaeppler, Lydie M. O. Barbeau, Arjan J. Groot, Ruth J. Muschel, Marc A. Vooijs
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
Intratumoural hypoxia is a common characteristic of malignant treatment-resistant cancers. However, hypoxia-modification strategies for the clinic remain elusive. To date, little is known on the behaviour of individual hypoxic tumour cells in their m
Externí odkaz:
https://doaj.org/article/06c80dc265d14a17aca588930a6cf945
Autor:
Keaton I Jones, Jiske Tiersma, Arseniy E Yuzhalin, Alex N Gordon‐Weeks, Jon Buzzelli, Jae Hong Im, Ruth J Muschel
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 12, Pp 1-16 (2018)
Abstract Emerging evidence suggests a role for radiation in eliciting anti‐tumour immunity. We aimed to investigate the role of macrophages in modulating the immune response to radiation. Irradiation to murine tumours generated from colorectal (MC3
Externí odkaz:
https://doaj.org/article/be307394213f42598b2d3a0581459ea3
Publikováno v:
Stem Cell Research, Vol 27, Iss , Pp 109-120 (2018)
Background: Colorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and is a leading cause of cancer-related death. Pre-clinical research of CRC liver metastasis predominately utilizes CRC cell lines grown in tissue culture
Externí odkaz:
https://doaj.org/article/c5c6ee3165a140de940bb8bc4c445a43
Autor:
Annelies Gonnissen, Sofie Isebaert, Christiaan Perneel, Chad M. McKee, Clare Verrill, Richard J. Bryant, Filip Van Utterbeeck, Evelyne Lerut, Karin Haustermans, Ruth J. Muschel
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-7 (2017)
Abstract Background Prostate cancer (PCa) is a heterogeneous disease with a variable natural history, genetics, and treatment outcome. The Hedgehog (Hh) signaling pathway is increasingly recognized as being potentially important for the development a
Externí odkaz:
https://doaj.org/article/73aa47090a9744e39ca68a40e77237b4
Autor:
Abul Azad, Su Yin Lim, Zenobia D'Costa, Keaton Jones, Angela Diana, Owen J Sansom, Philipp Kruger, Stanley Liu, W Gillies McKenna, Omer Dushek, Ruth J Muschel, Emmanouil Fokas
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 2, Pp 167-180 (2016)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is considered a non‐immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system. Here, we show that treatment of K
Externí odkaz:
https://doaj.org/article/a17cc1e2110a447185395eb66ec1791d
TNF-related apoptosis-inducing ligand (TRAIL) is a current focus for the development of new cancer therapies, because of its selective induction of apoptosis in cancer cells. TRAIL has previously been shown to be important for tumor cell clearance fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbd8f5e1a02d0e364e834594bd744a1
https://doi.org/10.1158/1541-7786.c.6541968.v1
https://doi.org/10.1158/1541-7786.c.6541968.v1
