Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Ruth Hüttenhain"'
Autor:
Rohini S. Ople, Nokomis Ramos-Gonzalez, Qiongyu Li, Briana L. Sobecks, Deniz Aydin, Alexander S. Powers, Abdelfattah Faouzi, Benjamin J. Polacco, Sarah M. Bernhard, Kevin Appourchaux, Sashrik Sribhashyam, Shainnel O. Eans, Bowen A. Tsai, Ron O. Dror, Balazs R. Varga, Haoqing Wang, Ruth Hüttenhain, Jay P. McLaughlin, Susruta Majumdar
Publikováno v:
ACS Central Science, Vol 10, Iss 8, Pp 1490-1503 (2024)
Externí odkaz:
https://doaj.org/article/85002e8675b5414c9f0b93723260a5ff
Autor:
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Aaron Marley, Helene Foussard, Prachi Khare, Rasika Vartak, Jiewei Xu, Jeffrey F DiBerto, Bryan L Roth, Manon Eckhardt, Mark von Zastrow, Nevan J Krogan, Ruth Hüttenhain
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 8, Pp 952-971 (2024)
Abstract Proximity labeling (PL) via biotinylation coupled with mass spectrometry (MS) captures spatial proteomes in cells. Large-scale processing requires a workflow minimizing hands-on time and enhancing quantitative reproducibility. We introduced
Externí odkaz:
https://doaj.org/article/b1fa4dc8556644079c79cd440ac3a387
Autor:
Christine E. Peters, Ursula Schulze-Gahmen, Manon Eckhardt, Gwendolyn M. Jang, Jiewei Xu, Ernst H. Pulido, Conner Bardine, Charles S. Craik, Melanie Ott, Or Gozani, Kliment A. Verba, Ruth Hüttenhain, Jan E. Carette, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Actin histidine methyltransferase SETD3 is a host factor critical for the replication of enteroviruses. Here, the authors report the 3.5 Å cryoEM structure of SETD3 interacting with enterovirus CV-B3 2A protease, defining the actin-binding SET domai
Externí odkaz:
https://doaj.org/article/22221195d9174bdcb9744f12954ad8ae
Autor:
Corvin D Arveseth, John T Happ, Danielle S Hedeen, Ju-Fen Zhu, Jacob L Capener, Dana Klatt Shaw, Ishan Deshpande, Jiahao Liang, Jiewei Xu, Sara L Stubben, Isaac B Nelson, Madison F Walker, Kouki Kawakami, Asuka Inoue, Nevan J Krogan, David J Grunwald, Ruth Hüttenhain, Aashish Manglik, Benjamin R Myers
Publikováno v:
PLoS Biology, Vol 19, Iss 4, p e3001191 (2021)
The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein-coupled receptor (GPCR) Smoothened (SMO) act
Externí odkaz:
https://doaj.org/article/216a829c67014ffaad7616967d505e59
Autor:
Tatjana Sajic, Yansheng Liu, Eirini Arvaniti, Silvia Surinova, Evan G. Williams, Ralph Schiess, Ruth Hüttenhain, Atul Sethi, Sheng Pan, Teresa A. Brentnall, Ru Chen, Peter Blattmann, Betty Friedrich, Emma Niméus, Susanne Malander, Aurelius Omlin, Silke Gillessen, Manfred Claassen, Ruedi Aebersold
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2819-2831.e5 (2018)
Cancer is mostly incurable when diagnosed at a metastatic stage, making its early detection via blood proteins of immense clinical interest. Proteomic changes in tumor tissue may lead to changes detectable in the protein composition of circulating bl
Externí odkaz:
https://doaj.org/article/f69a33aae6bb4289a7cf96673277a7c8
Autor:
Lili Zhu, Krishna Choudhary, Barbara Gonzalez-Teran, Yen-Sin Ang, Reuben Thomas, Nicole R. Stone, Lei Liu, Ping Zhou, Chenchen Zhu, Hongmei Ruan, Yu Huang, Shibo Jin, Angelo Pelonero, Frances Koback, Arun Padmanabhan, Nandhini Sadagopan, Austin Hsu, Mauro W. Costa, Casey A. Gifford, Joke G. van Bemmel, Ruth Hüttenhain, Vasanth Vedantham, Bruce R. Conklin, Brian L. Black, Benoit G. Bruneau, Lars Steinmetz, Nevan J. Krogan, Katherine S. Pollard, Deepak Srivastava
Publikováno v:
Circulation. 146(10)
Background: GATA4 (GATA-binding protein 4), a zinc finger–containing, DNA-binding transcription factor, is essential for normal cardiac development and homeostasis in mice and humans, and mutations in this gene have been reported in human heart def
Autor:
Xiaofang Zhong, Qiongyu Li, Benjamin J. Polacco, Trupti Patil, Jeffrey F. DiBerto, Rasika Vartak, Jiewei Xu, Aaron Marley, Helene Foussard, Bryan L. Roth, Manon Eckhardt, Mark Von Zastrow, Nevan J. Krogan, Ruth Hüttenhain
Proximity labeling (PL) coupled with mass spectrometry has emerged as a powerful technique to map proximal protein interactions in living cells. Large-scale sample processing for proximity proteomics necessitates a high-throughput workflow to reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5d54e5dce5c8105f7c6f2235b090509
https://doi.org/10.1101/2023.04.11.536358
https://doi.org/10.1101/2023.04.11.536358
Autor:
Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales, Adrian Pelin, Jyoti Batra, Gwendolyn Jang, Jiewei Xu, Jack M. Moen, Alicia L. Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, Giuditta De Lorenzo, Vanessa Cowton, Abdullah M. Syed, Alison Ciling, Noa Deutsch, Daniel Pirak, Giulia Dowgier, Dejan Mesner, Jane L. Turner, Briana L. McGovern, M. Luis Rodriguez, Rocio Leiva-Rebollo, Alistair S. Dunham, Xiaofang Zhong, Manon Eckhardt, Andrea Fossati, Nicholas Liotta, Thomas Kehrer, Anastasija Cupic, Magda Rutkowska, Nacho Mena, Sadaf Aslam, Alyssa Hoffert, Helene Foussard, Charles Olwal, Weiqing Huang, Thomas Zwaka, John Pham, Molly Lyons, Laura Donohue, Aliesha Griffin, Rebecca Nugent, Kevin Holden, Robert Deans, Pablo Aviles, José Antonio López, José María Jimeno Doñaque, Kirsten Obernier, Jacqueline M. Fabius, Margaret Soucheray, Ruth Hüttenhain, Irwin Jungreis, Manolis Kellis, Ignacia Echeverria, Kliment Verba, Paola Bonfanti, Pedro Beltrao, Roded Sharan, Jennifer A. Doudna, Luis Martinez-Sobrido, Arvind Patel, Massimo Palmarini, Lisa Miorin, Kris White, Danielle L. Swaney, Adolfo Garcia-Sastre, Clare Jolly, Lorena Zuliani-Alvarez, Greg J. Towers, Nevan J. Krogan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1fac14fca4140ce96becc2c3766070b
https://doi.org/10.2139/ssrn.4319535
https://doi.org/10.2139/ssrn.4319535
Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories
Autor:
Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales, Adrian Pelin, Jyoti Batra, Gwendolyn M. Jang, Jiewei Xu, Jack M. Moen, Alicia Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, Giuditta De Lorenzo, Vanessa Cowton, Abdullah M. Syed, Alison Ciling, Noa Deutsch, Daniel Pirak, Giulia Dowgier, Dejan Mesner, Jane L. Turner, Briana L. McGovern, M. Luis Rodriguez, Rocio Leiva-Rebollo, Alistair S. Dunham, Xiaofang Zhong, Manon Eckhardt, Andrea Fossati, Nicholas Liotta, Thomas Kehrer, Anastasija Cupic, Magda Rutkowska, Nacho Mena, Sadaf Aslam, Alyssa Hoffert, Helene Foussard, John Pham, Molly Lyons, Laura Donahue, Aliesha Griffin, Rebecca Nugent, Kevin Holden, Robert Deans, Pablo Aviles, José Antonio López-Martín, Jose M. Jimeno, Kirsten Obernier, Jacqueline M. Fabius, Margaret Soucheray, Ruth Hüttenhain, Irwin Jungreis, Manolis Kellis, Ignacia Echeverria, Kliment Verba, Paola Bonfanti, Pedro Beltrao, Roded Sharan, Jennifer A. Doudna, Luis Martinez-Sobrido, Arvind Patel, Massimo Palmarini, Lisa Miorin, Kris White, Danielle L. Swaney, Adolfo García-Sastre, Clare Jolly, Lorena Zuliani-Alvarez, Greg J. Towers, Nevan J. Krogan
A series of SARS-CoV-2 variants of concern (VOCs) have evolved in humans during the COVID-19 pandemic—Alpha, Beta, Gamma, Delta, and Omicron. Here, we used global proteomic and genomic analyses during infection to understand the molecular responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c8567a33da825246dd5aa0c0571375e
https://doi.org/10.1101/2022.10.19.512927
https://doi.org/10.1101/2022.10.19.512927
Autor:
Benjamin J. Polacco, Braden T. Lobingier, Emily E. Blythe, Nohely Abreu, Jiewei Xu, Qiongyu Li, Zun Zar Chi Naing, Brian K. Shoichet, Joshua Levitz, Nevan J. Krogan, Mark Von Zastrow, Ruth Hüttenhain
G protein-coupled receptors (GPCRs) regulate many aspects of physiology and represent actionable targets for drug discovery. These receptors translate ligand-dependent input into a cellular response by remodeling protein interaction networks that are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f7536df9f3183f718a6b7c16539af5f
https://doi.org/10.1101/2022.03.28.486115
https://doi.org/10.1101/2022.03.28.486115