Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Ruth Heidelberger"'
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
Biallelic loss-of-function mutations in the syntaxin 3 gene have been linked to a severe retinal dystrophy in humans that presents in early childhood. In mouse models, biallelic inactivation of the syntaxin 3 gene in photoreceptors rapidly leads to t
Externí odkaz:
https://doaj.org/article/8cac4d5123144973a589e51acf71e1b8
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1463 (2023)
Retinal neurons that form ribbon-style synapses operate over a wide dynamic range, continuously relaying visual information to their downstream targets. The remarkable signaling abilities of these neurons are supported by specialized presynaptic mach
Externí odkaz:
https://doaj.org/article/33d5ba4b27c1486fa25893bafa3f2e2f
Autor:
Joseph R. Campbell, Hongyan Li, Yanzhao Wang, Maxim Kozhemyakin, Albert J. Hunt, Xiaoqin Liu, Roger Janz, Ruth Heidelberger
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Neurotransmitter release at retinal ribbon-style synapses utilizes a specialized t-SNARE protein called syntaxin3B (STX3B). In contrast to other syntaxins, STX3 proteins can be phosphorylated in vitro at T14 by Ca2+/calmodulin-dependent protein kinas
Externí odkaz:
https://doaj.org/article/246ba9360ac942518dacb619895e8280
An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerv
Autor:
Andreas R. Janecke, Lukas A. Huber, Roberto Adachi, Valeria Strauß, Anuradha Ganesh, Siham Al Sinani, Martha P. Schatz, Roger Janz, Badr AlSaleem, Martin Walter Laass, Majid Alfadhel, Sumanth Punuru, Elizabeth Sanchez, Xiaoqin Liu, Naveen Mittal, Fowzan S. Alkuraya, Ujwala S. Saboo, Rüdiger Adam, Sana Al Zuhaibi, Klaus Rohrschneider, Fathiya Al Murshedi, Thomas Müller, Ruth Heidelberger, Johanna C. Escher, Arne Viestenz
Publikováno v:
Human Genetics, 140(8), 1143-1156. Springer-Verlag
Human Genetics
Human Genetics
Biallelic STX3 variants were previously reported in five individuals with the severe congenital enteropathy, microvillus inclusion disease (MVID). Here, we provide a significant extension of the phenotypic spectrum caused by STX3 variants. We report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61dc5a4535447fa78f5680c9aee003e4
http://www.scopus.com/inward/record.url?scp=85105860540&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85105860540&partnerID=8YFLogxK
Autor:
Marco A. Ramos, Ruth Heidelberger, Roberto J. Alcazar-Felix, Roberto Adachi, Eduardo I. Cardenas, Alan R. Burns, Alejandro I. Rodarte, Ricardo Treviño González, Rodolfo A. Cardenas, Alejandro Isaza, Elizabeth Sanchez
Publikováno v:
The Journal of Biological Chemistry
Degranulation, a fundamental effector response from mast cells (MCs) and platelets, is an example of regulated exocytosis. This process is mediated by SNARE proteins and their regulators. We have previously shown that several of these proteins are es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8204093fa71125dcdeede86da55ba3ae
http://europepmc.org/articles/PMC7948755
http://europepmc.org/articles/PMC7948755
Autor:
Ruth Heidelberger, John O'Brien, Jaya Aseervatham, Ya-Ping Lin, Cheryl K. Mitchell, Xiaofan Li
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6346, p 6346 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 17
International Journal of Molecular Sciences
Volume 21
Issue 17
Calmodulin binding is a nearly universal property of gap junction proteins, imparting a calcium-dependent uncoupling behavior that can serve in an emergency to decouple a stressed cell from its neighbors. However, gap junctions that function as elect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0239199c777b06a0d38b97157a6b94e
https://pubmed.ncbi.nlm.nih.gov/32882943
https://pubmed.ncbi.nlm.nih.gov/32882943
Publikováno v:
Biophysical Journal. 113:2281-2298
Neurons that form ribbon-style synapses are specialized for continuous exocytosis. To this end, their synaptic terminals contain numerous synaptic vesicles, some of which are ribbon associated, that have difference susceptibilities for undergoing Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf14628ed91cd745ca374002bc997f2
https://doi.org/10.1016/j.bpj.2017.08.012
https://doi.org/10.1016/j.bpj.2017.08.012
Autor:
Justin J. Grassmeyer, Roger Janz, Cassandra L. Hays, Ruth Heidelberger, Wallace B. Thoreson, Xiangyi Wen
Publikováno v:
Biophys J
First proposed as a specialized mode of release at sensory neurons possessing ribbon synapses, multivesicular release has since been described throughout the central nervous system. Many aspects of multivesicular release remain poorly understood. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c396015b950dd7824f2b59b46b646b
https://europepmc.org/articles/PMC7036726/
https://europepmc.org/articles/PMC7036726/
Autor:
Elizabeth Sanchez, Alejandro Tortoriello, Miguel A. Chavez, Alan R. Burns, Alfredo J. Davalos, Youlia Petrova, Roberto Adachi, Erika A. Gonzalez, Berenice A. Gutierrez, Marco A. Ramos, John Manllo, David S. Moreno, Alejandro I. Rodarte, Rodolfo A. Cardenas, Daniel C. Moreira, Adolfo Lara, Ruth Heidelberger
Publikováno v:
The Journal of biological chemistry. 294(9)
Mast cells (MCs) participate in allergy, inflammation, and defense against pathogens. They release multiple immune mediators via exocytosis, a process that requires SNARE proteins, including syntaxins (Stxs). The identity of the Stxs involved in MC e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee30bb9d522950153c4aa60c9998e75
https://pubmed.ncbi.nlm.nih.gov/30563839
https://pubmed.ncbi.nlm.nih.gov/30563839