Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Ruth Gordillo"'
Autor:
Toshiharu Onodera, May-Yun Wang, Joseph M. Rutkowski, Stanislaw Deja, Shiuhwei Chen, Michael S. Balzer, Dae-Seok Kim, Xuenan Sun, Yu A. An, Bianca C. Field, Charlotte Lee, Ei-ichi Matsuo, Monika Mizerska, Ina Sanjana, Naoto Fujiwara, Christine M. Kusminski, Ruth Gordillo, Laurent Gautron, Denise K. Marciano, Ming Chang Hu, Shawn C. Burgess, Katalin Susztak, Orson W. Moe, Philipp E. Scherer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types beyond adipocytes, particularly in kidney tubular cells, but its local renal role is un
Externí odkaz:
https://doaj.org/article/6885cd75dd3641e481d840972315e815
Autor:
Toshiharu Onodera, Dae-Seok Kim, Risheng Ye, May-Yun Wang, Shiuhwei Chen, Bianca C. Field, Leon Straub, Xue-Nan Sun, Chao Li, Charlotte Lee, Megan Paredes, Clair Crewe, Shangang Zhao, Christine M. Kusminski, Ruth Gordillo, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101821- (2023)
The disease progression of the metabolic syndrome is associated with prolonged hyperlipidemia and insulin resistance, eventually giving rise to impaired insulin secretion, often concomitant with hypoadiponectinemia. As an adipose tissue derived hormo
Externí odkaz:
https://doaj.org/article/2a4c59c398c7494fb3ba2aafae8e0020
Autor:
Ran Song, Aaron Fond, Xiaohong Li, Miao Tang, Xiaoming Zhan, Ruth Gordillo, Eva Marie Y. Moresco, Bruce Beutler, Emre E. Turer
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/4a61c0b13b4b4dca914b71c98d8e2e61
Autor:
Alex B. Smith, Jonah P. Schill, Ruth Gordillo, Grace E. Gustafson, Timothy W. Rhoads, Maggie S. Burhans, Aimee T. Broman, Ricki J. Colman, Philipp E. Scherer, Rozalyn M. Anderson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Metabolic syndrome increases risk of complicating co-morbidities. Current clinical indicators reflect established metabolic impairment, preventing earlier intervention strategies. Here we show that circulating sphingolipids are altered in th
Externí odkaz:
https://doaj.org/article/43f3986a7da74abcbd070096cce668a7
Autor:
Yi Zhu, Na Li, Mingyang Huang, Mason Bartels, Sophie Dogné, Shangang Zhao, Xi Chen, Clair Crewe, Leon Straub, Lavanya Vishvanath, Zhuzhen Zhang, Mengle Shao, Yongjie Yang, Christy M. Gliniak, Ruth Gordillo, Gordon I. Smith, William L. Holland, Rana K. Gupta, Bingning Dong, Nathalie Caron, Yong Xu, Yucel Akgul, Samuel Klein, Philipp E. Scherer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Hyaluronan is a naturally occurring linear polysaccharide that together with collagens, enzymes, and glycoproteins forms the extracellular matrix. Here the authors show that adipose tissue overproduction of Hyaluronan reduces fat accumulation in mice
Externí odkaz:
https://doaj.org/article/d5d6f30432264ee3a4a2783133e16a29
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
The metabolic environment is important for neuronal cells, such as photoreceptors. When photoreceptors undergo degeneration, as occurs during retinitis pigmentosa (RP), patients have progressive loss of vision that proceeds to full blindness. Current
Externí odkaz:
https://doaj.org/article/7a899513322d46e4b5d15cabb24ae68d
Autor:
Na Li, Shangang Zhao, Zhuzhen Zhang, Yi Zhu, Christy M Gliniak, Lavanya Vishvanath, Yu A An, May-yun Wang, Yingfeng Deng, Qingzhang Zhu, Bo Shan, Amber Sherwood, Toshiharu Onodera, Orhan K Oz, Ruth Gordillo, Rana K Gupta, Ming Liu, Tamas L Horvath, Vishwa Deep Dixit, Philipp E Scherer
Publikováno v:
eLife, Vol 10 (2021)
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects
Externí odkaz:
https://doaj.org/article/cc9c31e77b504b8e89c7e9bde51878cd
Autor:
Toshiharu Onodera, Ebrahim Ghazvini Zadeh, Peng Xu, Ruth Gordillo, Zheng Guo, Nolwenn Joffin, Biao Yu, Philipp E. Scherer, Wen-hong Li
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100095- (2021)
The pleiotropic actions of adiponectin in improving cell survival and metabolism have motivated the development of small-molecule therapeutic agents for treating diabetes and lipotoxicity. AdipoRon is a synthetic agonist of the adiponectin receptors,
Externí odkaz:
https://doaj.org/article/603d78096ac94e35919ddb21f9c41f1a
Autor:
Irene Esposito, Michael Roden, Christian Herder, Maria Apostolopoulou, Ruth Gordillo, Sofiya Gancheva, Klaus Strassburger, Matthias Schlensak, Philipp E Scherer
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 2 (2020)
Introduction Sphingolipid accumulation has been linked to obesity, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). A recent study showed that depletion of dihydroceramide desaturase-1 (DES-1) in adipose and/or liver tissue decreases ce
Externí odkaz:
https://doaj.org/article/9dcfaec610494d1dbc5e1709698ad571
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Metabolic dysfunction is intertwined with the pathophysiology of both diabetes and cardiovascular disease. Recently, one particular lipid class has been shown to influence the development and sustainment of these diseases: ceramides. As a subtype of
Externí odkaz:
https://doaj.org/article/7772447eb63d4aab8afe4be39a8470db