Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ruth Feltell"'
Autor:
Rebecca Foster, Sue Griffin, Suzanne Grooby, Ruth Feltell, Cindy Christopherson, Monica Chang, John Sninsky, Shirley Kwok, Chris Torrance
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45061 (2012)
Targeting tumour metabolism is becoming a major new area of pharmaceutical endeavour. Consequently, a systematic search to define whether there are specific energy source dependencies in tumours, and how these might be dictated by upstream driving ge
Externí odkaz:
https://doaj.org/article/834d1b4441a949d0bfb401466e5229ca
Autor:
Neil T. Thompson, David R. Newell, Christopher Murray, Julie Irving, John Lyons, Eddy Freyne, Edward J. Lewis, Jose Cosme, Andrew Pike, Brent L. Graham, Lindsay A. Devine, Susanne Bethell, Abarna Thiru, Ruth Feltell, Darcey Miller, Maria Carr, Sharna Rich, Michael A. Batey, Christopher Hamlett, Michael Reader, Martyn Frederickson, Alistair O'Brien, Emma Vickerstaffe, Rajdeep K. Benning, Andrew Madin, Charlotte Griffiths Jones, Douglas Ross, Lynsey Fazal, Tim Perera, Patrick Angibaud, Peter King, Anne Cleasby, Valerio Berdini, Gordan Saxty, George Ward, Matthew Squires
We describe here the identification and characterization of 2 novel inhibitors of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases. The compounds exhibit selective inhibition of FGFR over the closely related VEGFR2 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605eebdec9c9d2137ffcbba68a3b82cd
https://doi.org/10.1158/1535-7163.c.6535227
https://doi.org/10.1158/1535-7163.c.6535227
Autor:
Neil T. Thompson, David R. Newell, Christopher Murray, Julie Irving, John Lyons, Eddy Freyne, Edward J. Lewis, Jose Cosme, Andrew Pike, Brent L. Graham, Lindsay A. Devine, Susanne Bethell, Abarna Thiru, Ruth Feltell, Darcey Miller, Maria Carr, Sharna Rich, Michael A. Batey, Christopher Hamlett, Michael Reader, Martyn Frederickson, Alistair O'Brien, Emma Vickerstaffe, Rajdeep K. Benning, Andrew Madin, Charlotte Griffiths Jones, Douglas Ross, Lynsey Fazal, Tim Perera, Patrick Angibaud, Peter King, Anne Cleasby, Valerio Berdini, Gordan Saxty, George Ward, Matthew Squires
PDF file - 475K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe1a33d4a31585a984d85c6194526c9
https://doi.org/10.1158/1535-7163.22496319
https://doi.org/10.1158/1535-7163.22496319
Autor:
John Lyons, Alexis De Haven Brandon, Paul Workman, Florence I. Raynaud, Kathrin Heinzmann, Melanie Valenti, Paul D. Eve, Neil T. Thompson, Anna Zetterlund, Ruth Feltell, Kyla Grimshaw, Matthias Reule, Michelle D. Garrett, Suzanne A. Eccles, Robert te Poele, Timothy A. Yap, Simon P. Heaton, Paul S. Jones, Steven John Woodhead, Vanessa Martins, Michael I. Walton, T.G. Davies
Publikováno v:
Clinical Cancer Research. 18:3912-3923
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitu
Autor:
Wrona Wojciech, Deborah J. Davis, Hayley Angove, Christopher Thomas Brain, Alison Jo-Anne Woolford, Fan Yang, Kim Lewry, Hong Cheng, Steven Kovats, Chen Christine Hiu-Tung, Alice Loo, Mei Xu, Claudio Dagostin, Miles Congreve, David C. Rees, John William Giraldes, Yaping Wang, Young Shin Cho, Glyn Williams, Rachel McMenamin, Troy Smith, Junqing Shen, Rajiv Chopra, Ruth Feltell, Yipin Lu, Wiesia Maniara, Bharat Lagu, Steven Howard, Kristy Chung, Robert Cheng, Steven Douglas Hiscock, Sunkyu Kim, Luzzio Michael, Marc O'Reilly, Rajdeep Benning, Paul N. Mortenson
Publikováno v:
ACS Medicinal Chemistry Letters. 3:445-449
Herein, we describe the discovery of potent and highly selective inhibitors of both CDK4 and CDK6 via structure-guided optimization of a fragment-based screening hit. CDK6 X-ray crystallography and pharmacokinetic data steered efforts in identifying
Autor:
Joe Coyle, Tomoko Smyth, Jayne Curry, Nicola G. Wallis, David M. Cross, Ruth Feltell, Isobel Harada, Brent Graham, Matthias Reule, Brian Williams, Hayley Angove, Lynsey Fazal, John Lyons, Neil T. Thompson
Publikováno v:
Cancer Sci
A ubiquitously expressed chaperone, heat shock protein 90 (HSP90) is of considerable interest as an oncology target because tumor cells and oncogenic proteins are acutely dependent on its activity. AT13387 (2,4‐dihydroxy‐5‐isopropyl‐phenyl)
Autor:
Martyn Frederickson, Christopher W. Murray, Neil T. Thompson, Tim Perera, Anne Cleasby, Eddy Jean Edgard Freyne, Ruth Feltell, Jose Cosme, Lynsey Fazal, Christopher Charles Frederick Hamlett, Michael Reader, Rajdeep Benning, Alistair O'Brien, Peter King, Darcey Miller, Matthew Squires, Patrick Angibaud, Andrew Madin, Valerio Berdini, Emma Vickerstaffe, Gordon Saxty, Brent Graham, Charlotte Griffiths Jones, Andrew Pike, Edward J. Lewis, Michael A. Batey, Douglas D. Ross, Susanne S. Bethell, Sharna J. Rich, Lindsay A. Devine, Maria Grazia Carr, Abarna Thiru, Julie Irving, George Ward, John Lyons, David R. Newell
Publikováno v:
Molecular Cancer Therapeutics. 10:1542-1552
We describe here the identification and characterization of 2 novel inhibitors of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases. The compounds exhibit selective inhibition of FGFR over the closely related VEGFR2 rec
Autor:
Nicola G. Wallis, Matthew S Squires, John Lyons, Ruth Feltell, E. Jonathan Lewis, Neil T. Thompson, David M. Cross, Donna-Michelle Smith
Publikováno v:
Molecular Cancer Therapeutics. 8:324-332
Cyclin-dependent kinases (CDK), and their regulatory cyclin partners, play a central role in eukaryotic cell growth, division, and death. This key role in cell cycle progression, as well as their deregulation in several human cancers, makes them attr
Autor:
John A. Boulstridge, Theresa Rachel Early, Gordon Saxty, Rachel McMenamin, Matthias Reule, David M. Cross, Lindsay A. Devine, Gary Trewartha, Michael Alistair O'brien, E. Jonathan Lewis, Paul Graham Wyatt, Eva Figueroa Navarro, M. Squires, Margaret T. Walker, Alison Jo-Anne Woolford, Lisa C A Seavers, Valerio Berdini, Marc O'Reilly, Maria Grazia Carr, Andrew James Woodhead, Donna-Michelle Smith, Deborah J. Davis, Ruth Feltell
Publikováno v:
Journal of Medicinal Chemistry. 51:4986-4999
The application of fragment-based screening techniques to cyclin dependent kinase 2 (CDK2) identified multiple (>30) efficient, synthetically tractable small molecule hits for further optimization. Structure-based design approaches led to the identif
Autor:
Sue Griffin, Cindy Christopherson, Shirley Kwok, Rebecca R. Foster, Suzanne Grooby, Chris Torrance, Monica Chang, John J. Sninsky, Ruth Feltell
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45061 (2012)
PLoS ONE
PLoS ONE
Targeting tumour metabolism is becoming a major new area of pharmaceutical endeavour. Consequently, a systematic search to define whether there are specific energy source dependencies in tumours, and how these might be dictated by upstream driving ge